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Creon Corporation plc (AMED)

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Wednesday 13 August, 2008

Creon Corporation plc

TR-1: Notifications of Major Interests in Shares

TR-1: Notifications of Major Interests in Shares                               

1. Identity of the issuer or the underlying       Creon Corporation Plc        
issuer of existing shares to which voting rights                               
are attached:                                                                  
2. Reason for notification (yes/no)                                            
An acquisition or disposal of voting rights                                    
An acquisition or disposal of financial instruments which may                  
result in the acquisition of shares already issued to which voting             
rights are attached                                                            
An event changing the breakdown of voting rights           Yes        
Other (please specify):______________                                          
3. Full name of person(s) subject to       Deutsche Bank AG                    
notification obligation:                                                       
4. Full name of shareholder(s) (if                                             
different from 3):                                                             
5. Date of transaction (and date on which  N/A                                 
the threshold is crossed or reached if                                         
6. Date on which issuer notified:          07/08/08                            
7. Threshold(s) that is/are crossed or     8%                                  
8: Notified Details                                                            
A: Voting rights attached to shares                                            
Class/type   Situation         Resulting situation after the triggering        
of shares    previous to the   transaction                                     
If possible  transaction                                                       
use ISIN                                                                       

Number of    Number  Number  Number of voting   Percentage of   
shares       of      of      rights             voting rights   
             voting  shares                                     
                             Direct    Indirect Direct Indirect 
GB00B02TDY97 893,214 893,214 893,214 893,214     7.42%          

B: Financial Instruments                                                       
Resulting situation after the triggering transaction                           
Type of        Expiration     Exercise/       No. of voting      Percentage of 
financial      date           conversion      rights that may be voting rights 
instrument                    period/date     acquired (if the                 

Total (A+B)                                                                    
Number of voting rights                 Percentage of voting rights            
893,214                                 7.42%                                  

9. Chain of controlled undertakings through which the voting rights and /or the
financial instruments are effectively held, if applicable:                     

Proxy Voting:                                                                  
10. Name of proxy holder:                                                      
11. Number of voting rights proxy                                              
holder will cease to hold:                                                     
12. Date on which proxy holder will                                            
cease to hold voting rights:                                                   

13. Additional information:                                                    
14 Contact name:                        David Lindsay\Andrew Anderson          
15. Contact telephone number:           +00 44 207 545 8533\8532               

For further information please contact:

Creon Corporation Plc Jonathan Freeman +44 (0)20 7752 0215

Daniel Stewart & Company Plc Oliver Rigby +44 (0)207 776 6550

GTH Media Relations Toby Hall +44 (0)20 7153 8039

Christian Pickel +44 (0)20 7153 8036


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