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Creon Corporation plc (AMED)

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Wednesday 06 August, 2008

Creon Corporation plc

TR-1 Notifications of Major Interests in Shares

TR-1: Notifications of Major Interests in Shares                               

1. Identity of the issuer or the underlying       Creon Corporation Plc        
issuer of existing shares to which voting rights                               
are attached:                                                                  
2. Reason for notification (yes/no)                                            
An acquisition or disposal of voting rights                                    
An acquisition or disposal of financial instruments which may                  
result in the acquisition of shares already issued to which voting             
rights are attached                                                            
An event changing the breakdown of voting rights                    Yes        
Other (please specify):______________                                          
3. Full name of person(s) subject to       Credit Agricole Cheuvreux           
notification obligation:                   International Ltd                   
4. Full name of shareholder(s) (if                                             
different from 3):                                                             
5. Date of transaction (and date on which  01/08/08                            
the threshold is crossed or reached if                                         
6. Date on which issuer notified:          05/08/08                            
7. Threshold(s) that is/are crossed or     10%                                 
8: Notified Details                                                            
A: Voting rights attached to shares                                            
Class/type   Situation         Resulting situation after the triggering        
of shares    previous to the   transaction                                     
If possible  transaction                                                       
use ISIN                                                                       

Number of    Number of Number of Number of voting     Percentage of    
shares       voting    shares    rights               voting rights    
                                 Direct      Indirect Direct  Indirect 
Ordinary     1,106,786 1,106,786 1,106,786 1,106,786  0 9.19% 0        

B: Financial Instruments                                                       
Resulting situation after the triggering transaction                           
Type of        Expiration     Exercise/       No. of voting      Percentage of 
financial      date           conversion      rights that may be voting rights 
instrument                    period/date     acquired (if the                 

Total (A+B)                                                                    
Number of voting rights                 Percentage of voting rights            
1,106,786                               9.19%                                  

9. Chain of controlled undertakings through which the voting rights and /or the
financial instruments are effectively held, if applicable:                     
SAS Rue La Boétie                                                              
Crédit Agricole SA                                                             
Calyon SA                                                                      
Crédit Agricole Cheuvreux SA 1,106,786 (9.19%)                                 

Proxy Voting:                                                                  
10. Name of proxy holder:                                                      
11. Number of voting rights proxy                                              
holder will cease to hold:                                                     
12. Date on which proxy holder will                                            
cease to hold voting rights:                                                   

13. Additional information:                                                    
14 Contact name:                        Gabrielle Burne                        
15. Contact telephone number:           020 7214 6037                          

For further information please contact:

Creon Corporation Plc         Jonathan Freeman   +44 (0)20 7752 0215

Daniel Stewart & Company Plc  Oliver Rigby       +44 (0)207 776 6550

GTH Media Relations           Toby Hall          +44 (0)20 7153 8039
                              Christian Pickel   +44 (0)20 7153 8036


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