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Creon Corporation plc (AMED)

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Friday 10 July, 2009

Creon Corporation plc

TR-1: Notification of Major Interest in Shares

                             Creon Corporation Plc                             

                      ("Creon", "Company" or the "Group")                      

TR-1: Notifications of Major Interests in Shares                               

1. Identity of the issuer or the underlying       Creon Corporation Ord GBP    
issuer of existing shares to which voting rights  0.01p                        
are attached:                                                                  
2. Reason for notification (yes/no)                                            
An acquisition or disposal of voting rights                         Yes        
An acquisition or disposal of financial instruments which may                  
result in the acquisition of shares already issued to which voting             
rights are attached                                                            
An event changing the breakdown of voting rights                               
Other (please specify):______________                                          
3. Full name of person(s) subject to       The Royal Bank of Scotland Group Plc
notification obligation:                                                       
4. Full name of shareholder(s) (if         Adam & Co (Nominees) Ltd A/C AIM    
different from 3):                                                             
5. Date of transaction (and date on which  03/07/2009                          
the threshold is crossed or reached if                                         
6. Date on which issuer notified:          06/07/2009                          
7. Threshold(s) that is/are crossed or     5%                                  
8: Notified Details                                                            
A: Voting rights attached to shares                                            
Class/type   Situation         Resulting situation after the triggering        
of shares    previous to the   transaction                                     
If possible  transaction                                                       
use ISIN                                                                       

Number of    Number of Number Number of       Percentage of    
shares       voting    of     voting rights   voting rights    
             rights    shares                                  
                              Direct Indirect Direct  Indirect 
Ordinary     3,962,734 0      0    0          0 0.00% 0.00%    

B: Financial Instruments                                                       
Resulting situation after the triggering transaction                           
Type of        Expiration     Exercise/       No. of voting      Percentage of 
financial      date           conversion      rights that may be voting rights 
instrument                    period/date     acquired (if the                 

Total (A+B)                                                                    
Number of voting rights                 Percentage of voting rights            
0                                       0.00%                                  

9. Chain of controlled undertakings through which the voting rights and /or the
financial instruments are effectively held, if applicable:                     
The Royal Bank of Scotland Group Plc (0.00%)                                   
The Royal Bank of Scotland Plc (0.00%)                                         
Adam & Co Group Plc (0.00%)                                                    
Adam & Co Investment Management Ltd (0.00%)                                    

Proxy Voting:                                                                  
10. Name of proxy holder:                                                      
11. Number of voting rights proxy                                              
holder will cease to hold:                                                     
12. Date on which proxy holder will                                            
cease to hold voting rights:                                                   

13. Additional information:             This notification is based upon the    
                                        Voting Rights figure of 43,990,545     
                                        obtained from your Regulatory          
                                        Announcement dated 27th January 2009.  
14 Contact name:                        Richard Hopkins                        
15. Contact telephone number:           020 7714 4459                          

For further information please contact:

Creon Corporation Plc Jonathan Freeman +44 (0)20 7752 0215

Daniel Stewart & Company Plc Oliver Rigby +44 (0)207 776 6550

GTH Media Relations Toby Hall +44 (0)20 7153 8039

Christian Pickel +44 (0)20 7153 8036


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