Transaction in Own Shares

GlaxoSmithKline PLC
30 June 2006



GlaxoSmithKline plc (the "Company") announces that it has today put in place an
irrevocable, non-discretionary programme for the repurchase of its ordinary
shares during the close period which precedes the second quarter results
announcement expected to be made on 26 July 2006.

The buy back programme will be managed by an independent third party which makes
its trading decisions in relation to the Company's securities independently of,
and uninfluenced by, the Company.

Any repurchases pursuant to these arrangements will be effected during the
period between 1 July 2006 and 26 July 2006 within certain pre-set parameters
and in accordance with both the Listing Rules and the limitations of the
repurchase authority granted to the Directors at the last Annual General Meeting
of shareholders.  Any ordinary shares repurchased will be held as treasury
shares.


S M Bicknell
Company Secretary


30 June 2006


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