Holding(s) in Company

The Company has been notified today that the Co-operative Insurance Society
Limited holds as beneficial owner, or has an interest in, 1,799,000 ordinary
shares of Oxford Instruments plc as at the close of business on 21 November
2006, this being equal to 3.70% of the relevant issued share capital. The
decrease in our percentage holding was as a result of the following
transaction:

Date                      Transaction Type           Number of Ordinary Shares 
                                                                               
21/11/06                  Sale                       287,500                   

Co-operative Insurance Society Limited holds nil shares as beneficial owner. It
is also a limited partner in Aberforth Limited Partnership 1A and is interested
in 1,799,000 shares as a result of this participation.