Holding(s) in Company

The Company has been notified today that GAM London Limited has a notifiable
interest in 3,285,227 Ordinary Shares of 5p each which, represents 6.855% of
the issued share capital of Oxford Instruments plc.

The shares to which this notification relates are registered as follows:

Holding    Owned By                     Advised By            %          
                                                                         
660,000    SJPI GAM Sterling Managed    GAM London Limited    1.377      
           Fund                                                          
                                                                         
88,000     SJPI GAM US Dollar Managed   GAM London Limited    0.184      
           Fund                                                          
                                                                         
598,000    GAM International Growth     GAM London Limited    1.248      
           Fund                                                          
                                                                         
422,000    GAM UK Diversified           GAM London Limited    0.881      
                                                                         
85,000     GAM Exempt Trust - U.K.      GAM London Limited    0.177      
           Opportunities                                                 
                                                                         
661,000    SJP/GAM Managed - Life       GAM London Limited    1.379      
                                                                         
403,227    JRA/GAM Managed - Pension    GAM London Limited    0.841      
                                                                         
368,000    St James's Place Recovery    GAM London Limited    0.768      
           Unit Trust                                                    
                                                                         
3,285,227                                                     6.855%     

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