Holding(s) in Company

Oxford Instruments plc has been notified today, pursuant to Section 198 of the
Companies Act 1985, that HBOS plc and its subsidiaries have a material and
non-material interest of 4,800,457 Ordinary £0.05p shares in our Company, which
represents 10.02% of the shares in issue.

The shares to which this notification relates are registered as follows:

No of Shares       Fund                      Registered Holder               
                                                                             
3,680         FE1F            State Street Nominees                          
                                                                             
1,227,350     SJP'INTL        Bank of New York Nominees Ltd a/c 683007       
                                                                             
340,000       SJP RECOVERY    Bank of New York Nominees Ltd a/c 683003       
                                                                             
303,000       SJP RF32        HSBC Global Custody Nominees (UK) Ltd a/c      
                              872859                                         
                                                                             
180,227       SJP RF42        HSBC Global Custody Nominees (UK) Ltd a/c      
                              872860                                         
                                                                             
516,000       SJP RF80        HSBC Global Custody Nominees (UK) Ltd a/c      
                              823617                                         
                                                                             
284,000       SJP RF89        HSBC Global Custody Nominees (UK) Ltd a/c      
                              823629                                         
                                                                             
963,200       SJP UK & GEN    Bank of New York Nominees Ltd a/c 683005       
                                                                             
50,000        SJP RF56        HSBC Global Custody Nominees (UK) Ltd a/c      
                              823873                                         
                                                                             
74,000        SJPI RF59       HSBC Global Custody Nominees (UK) Ltd a/c      
                              823861                                         
                                                                             
509,000       SJPI RF62       HSBC Global Custody Nominees (UK) Ltd a/c      
                              823770                                         
                                                                             
300,000       SJPI RF63       HSBC Global Custody Nominees (UK) Ltd a/c      
                              823794                                         
                                                                             
50,000        SJPI RF67       HSBC Global Custody Nominees (UK) Ltd a/c      
                              823757