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Oxford Biomedica PLC (OXB)

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Wednesday 16 November, 2011

Oxford Biomedica PLC

Interim Management Statement

RNS Number : 1647S
Oxford Biomedica PLC
16 November 2011







Oxford BioMedica Interim Management Statement


Oxford, UK - 16 November 2011: Oxford BioMedica plc ("Oxford BioMedica" or "the Company") (LSE: OXB), the leading gene-based biopharmaceutical company, today publishes its interim management statement for the period from 1 July to 15 November 2011.



LentiVector® platform

ProSavin® (gene-based therapy for Parkinson's disease): development update

·      Treatment of all six patients in fourth cohort complete

·      Review of all four cohorts by the Data Monitoring Committee will be in December 2011


Ocular programmes (gene-based therapies targeting vision loss): partnered with Sanofi

·      RetinoStat® Phase I study: second ascending dose cohort complete

·      StarGen™ Phase I/IIa study: on-going with second site initiated in France

·      FDA approval received for UshStat® investigational new drug (IND) application in October 2011, Phase I/IIa study expected to be initiated by the end of 2011

·      Pre-IND meeting with FDA held in September 2011 for EncorStat®


New gene-based therapy for chronic glaucoma: in collaboration with Mayo Clinic

·      R&D agreement announced in October 2011



·      Re-commissioning of new lentiviral vector facility is on track, expected to be fully-operational in H1 2012


5T4 tumour antigen platform

Targeted antibody therapy for cancer: partnered with Pfizer

In September 2011, Pfizer presented new data at the ISREC Symposium which confirmed that 5T4 is the single oncology target for the antibody-drug conjugate (ADC) technology licensed from Seattle Genetics earlier this year.  The Oncology Research Unit has synthesised an anti-5T4 antibody-drug conjugate (ADC), called A1-mcMMAF, and has shown that A1-mcMMAF can eradicate tumor cells that have heterogeneous expression of 5T4.  As previously announced, Oxford BioMedica has licensed the exclusive, global right to market antibodies targeting the 5T4 tumour antigen for all human cancer indications to Pfizer.  The next milestone payment to Oxford BioMedica would be due if Pfizer initiates clinical trials.



The Company's net cash balance at 30 June 2011, as stated in the interim report, was £20.2 million.  At 31 October 2011 the Company had a net cash1 balance of £17.5 million.  Both figures are unaudited.



Oxford BioMedica continues to focus on delivering progress across its core programmes having advanced two ocular gene therapies into clinical development and agreed a new R&D collaboration for glaucoma with a worldwide leader in medical research during 2011.  With innovative technology platforms, world-class industry collaborations and data expected from its pioneering clinical studies throughout 2012, the Company looks forward to encouraging prospects ahead.


1 Cash, cash equivalents and current financial assets


John Dawson, Chief Executive Officer of Oxford BioMedica, said: "Developing pioneering gene therapy programmes demands a significant amount of R&D, regulatory, manufacturing and commercial expertise and, with five clinical programmes expected to be underway by the end of 2011, we are pleased with our achievements this year.  With clear strategic priorities ahead, all efforts remain focused on leveraging the potential of our novel technology platforms."




For further information, please contact:

Oxford BioMedica plc:

Lara Mott, Head of Corporate Communications

Tel: +44 (0)1865 783 000


Media Enquiries:

Mary Clark/Emma Thompson/Claire Dickinson



Tel: +44 (0)20 7920 2342



Notes to editors


1. Oxford BioMedica

Oxford BioMedica plc (LSE: OXB) is a biopharmaceutical company developing innovative gene-based medicines and therapeutic vaccines that aim to improve the lives of patients with high unmet medical needs.  The Company's technology platform includes a highly efficient LentiVector® gene delivery system, which has specific advantages for targeting diseases of the central nervous system and the eye; and a unique tumour antigen (5T4), which is an ideal target for anti-cancer therapy.  Through in-house and collaborative research, Oxford BioMedica has a broad pipeline with current partners and licensees including Sanofi, Pfizer, GlaxoSmithKline, MolMed, Sigma-Aldrich, Biogen Idec, VIRxSYS, Emergent BioSolutions and ImaginAb.  Further information is available at

This information is provided by RNS
The company news service from the London Stock Exchange

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