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Creon Corporation plc (AMED)

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Monday 08 September, 2008

Creon Corporation plc

TR-1: Notifications of Major Interests in Shares


TR-1: Notifications of Major Interests in Shares                               
                                                                             
1. Identity of the issuer or the underlying              
issuer of existing shares to which voting                                      
rights are attached: Creon Corporation Plc                                                           
                                                                               
2. Reason for notification (yes/no)                                            
                                                                               
An acquisition or disposal of voting rights    Yes                             
                                                                               
An acquisition or disposal of financial instruments which may result           
in the acquisition of shares already issued to which voting rights             
are attached                                                                   
                                                                               
An event changing the breakdown of voting rights                               
                                                                               
Other (please specify):______________                                          
                                                                               
3. Full name of person(s) subject to    Credit Agricole Cheuvreux International
notification obligation:                Ltd                                    
                                                                               
4. Full name of shareholder(s) (if                                             
different from 3):                                                             
                                                                               
5. Date of transaction (and date on     03/09/08                               
which the threshold is crossed or                                              
reached if different):                                                         
                                                                               
6. Date on which issuer notified:       05/09/08                               
                                                                               
7. Threshold(s) that is/are crossed or  Less than 3%                           
reached:                                                                       

8: Notified Details                                                           
                                                                              
A: Voting rights attached to shares                                           
                                                                              
Class/type of Situation previous  Resulting situation after the triggering    
shares        to the triggering   transaction                                 
              transaction                                                     
If possible                       Less than 3%                                
use ISIN code                                                                 
                                                                              
GB00B02TDY97                                                                  
                                                                              

Number of Number of Number   Number of voting Percentage of                   
shares    voting    of       rights           voting rights                   
          rights    shares                                                    
1,106,786                                                                     
          1,106,786          Direct  Indirect Direct  Indirect                
                                                                              

B: Financial Instruments                                                       
                                                                               
Resulting situation after the triggering transaction                           
                                                                               
Type of        Expiration     Exercise/       No. of voting      Percentage of 
financial      date           conversion      rights that may be voting rights 
instrument                    period/date     acquired (if the                 
                                              instrument                       
                                              exercised/                       
                                              converted)                       
                                                                               

Total (A+B)                                                                    
                                                                               
Number of voting rights                 Percentage of voting rights            
                                                                               

9. Chain of controlled undertakings through which the voting rights and /or the
financial instruments are effectively held, if applicable:                     
                                                                               
SAS Rue La Boétie                                                              
                                                                               
Crédit Agricole SA                                                             
                                                                               
Calyon SA                                                                      
                                                                               
Crédit Agricole Cheuvreux SA                                                   
                                                                               
Crédit Agricole Cheuvreux International Limited Less than 3%                   

Proxy Voting:                                                                  
                                                                               
10. Name of proxy holder:                                                      
                                                                               
11. Number of voting rights proxy                                              
holder will cease to hold:                                                     
                                                                               
12. Date on which proxy holder will                                            
cease to hold voting rights:                                                   

13. Additional information:                                                    
                                                                               
14 Contact name:                        Gabrielle Burne                        
                                                                               
15. Contact telephone name:             0207 214 6037                          

For further information please contact:

Creon Corporation Plc Jonathan Freeman +44 (0)20 7752 0215

Daniel Stewart & Company Plc Oliver Rigby +44 (0)207 776 6550

GTH Media Relations Toby Hall +44 (0)20 7153 8039

Christian Pickel +44 (0)20 7153 8036


                                                                                                                       

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