Director Shareholding

Oxford Biomedica PLC
28 September 2000



               Oxford BioMedica ('the Company')

Director's Share Options

On 27 September 2000, the Company granted options to Directors
over 1p ordinary shares ('Ordinary Shares') as follows:


Director             Options          Exercise           Date
                                     price (p)    Exercisable
                                                             
Neill        Moray    64,250              75.5      27.09.03-
MacKenzie                                            27.09.07
                                                             
Andrew Brian Wood     20,353              75.5      27.09.03-
                                                     27.09.07

In addition,  on 27 September 2000, the Company granted  8,449
options to Sharon Wood, the wife of  Andrew  Brian  Wood, at an
exercise price  of  75.5p exercisable between 27.09.03 - 27.09.07.

The  above  options  have all been granted  under  the  Oxford
BioMedica 1996 (1) Share Option Scheme.


FURTHER INFORMATION

Andrew Wood, Oxford BioMedica 01865 783000

Matthew Wood, Beeson Gregory  020 7488 4040