Annual Information Update

Oxford Biomedica PLC
11 April 2006


           Oxford BioMedica plc ('Oxford BioMedica' or the 'Company')

        Annual Information Update for the Twelve Months to 10 April 2006

This annual information update is filed pursuant to Prospectus Rule 5.2 made by
the Financial Services Authority and not for any other purpose and by filing
this annual information update neither the Company, nor any other person, takes
any responsibility for, or makes any representation, express or implied, as to
the accuracy or completeness of, the information contained or referred to below
herein. The information referred to below is not necessarily up to date as at
the date of this annual information update and the Company does not undertake
any obligation to update any such information in the future. Furthermore, such
information may have been prepared in accordance with the laws or regulations of
a particular jurisdiction and may not comply with or meet the relevant standards
of disclosure in any other jurisdiction. Neither this annual information update,
nor the information referred to below constitutes, by virtue of this
communication, an offer of any securities addressed to any person and should not
be relied on by any person.

1. Announcements made via a Regulatory Information Service

Date                                Announcement
---------------------------         --------------

6 April 2006                        Holding(s) in Company
24 March 2006                       Holding(s) in Company
23 March 2006                       Director/PDMR Shareholding
16 March 2006                       Director/PDMR Shareholding
14 March 2006                       Preliminary Results
10 March 2006                       VIRxSYS Corporation Licence
23 February 2006                    Notice of Results
3 February 2006                     Board Appointment
26 January 2006                     Holding(s) in Company
24 January 2006                     Holding(s) in Company
18 January 2006                     Viragen Milestone
4 January 2006                      Holding(s) in Company
20 December 2005                    Holding(s) in Company
19 December 2005                    Holding in Company Correction
19 December 2005                    Holding(s) in Company
19 December 2005                    Holding(s) in Company
16 December 2005                    Director/PDMR Shareholding Amend
16 December 2005                    Director/PDMR Shareholding
15 December 2005                    Director/PDMR Shareholding
12 December 2005                    Holding(s) in Company
12 December 2005                    Result of EGM
9 December 2005                     Holding(s) in Company
8 December 2005                     Holding(s) in Company
24 November 2005                    Holding(s) in Company
22 November 2005                    Blocklisting Interim Review
22 November 2005                    Holding(s) in Company
22 November 2005                    TroVax Notice of Allowance
17 November 2005                    Holding(s) in Company
16 November 2005                    Publication of Prospectus
16 November 2005                    Placing and Open Offer
15 November 2005                    Holding(s) in Company
2 November 2005                     TroVax & Proposed Fundraising
24 October 2005                     TroVax Clarification
24 October 2005                     Licence Agreement
20 October 2005                     Agreement with Sigma Aldrich
17 October 2005                     Final Phase II Results
6 October 2005                      Prelim Phase II Results
3 October 2005                      Change of Adviser
28 September 2005                   Holding(s) in Company
20 September 2005                   Interim Results
16 September 2005                   Holding(s) in Company
5 September 2005                    Notice of Results
25 August 2005                      Holding(s) in Company
18 August 2005                      Holding(s) in Company
17 August 2005                      Holding(s) in Company
1 August 2005                       Completion of Clinical Trial
25 July 2005                        Awarded Research Grant
6 July 2005                         Holding(s) in Company
30 June 2005                        Holding(s) in Company
29 June 2005                        Holding(s) in Company
17 June 2005                        Holding(s) in Company
16 June 2005                        Holding(s) in Company
6 June 2005                         Director Shareholding
6 June 2005                         Licensing Agreement
3 June 2005                         Innurex ASGT Data
19 May 2005                         Blocklisting Interim Review
16 May 2005                         Phase II trials of TroVax
12 May 2005                         Holding(s) in Company
10 May 2005                         AGM Statement
5 May 2005                          Preclinical Efficacy Data
27 April 2005                       Holding(s) in Company
22 April 2005                       Holding(s) in Company
20 April 2005                       Holding(s) in Company
15 April 2005                       Holding(s) in Company
29 March 2005                       Notice of AGM
29 March 2005                       Notice of Allowance
22 March 2005                       Director Shareholding
21 March 2005                       Exit of Investment
21 March 2005                       Final Results
4 March 2005                        Directorate Change
4 March 2005                        Notice of Results

Details of all regulatory announcements for Oxford BioMedica can be found on the
London Stock Exchange website at www.londonstockexchange.com and on the Oxford
BioMedica website at http://www.oxfordbiomedica.co.uk

2. Documents filed with Companies House

Date                  Document Type                  Description
--------------------- -----------------------        -------------

   10 February 2006   88(2) Return of Allotment of   Allotment 120,328,041 1p
                      shares                         Ord.
   12 December 2005   123 Notice of increase in      Increase by £1,500,000 to
                      nominal capital                £6,500,000
    20 October 2005   88(2) Return of Allotment of   Allotment 230,905 1p Ord.
                      shares
    20 October 2005   88(2) Return of Allotment of   Allotment 111,979 1p Ord.
                      shares
    20 October 2005   88(2) Return of Allotment of   Allotment 26,387 1p Ord.
                      shares
  29 September 2005   363s Annual Return
              
  26 September 2005   88(2) Return of Allotment of   Allotment 404,494 1p Ord.
                      shares
  21 September 2005   88(2) Return of Allotment of   Allotment 494,258 1p Ord.
                      shares
   8 September 2005   88(2) Return of Allotment of   Allotment 165,428 1p Ord.
                      shares
     24 August 2005  88(2) Return of Allotment of   Allotment 486,776 1p Ord.
                      shares
      4 August 2005   88(2) Return of Allotment of   Allotment 232,508 1p Ord.
                      shares
       27 July 2005   88(2) Return of Allotment of   Allotment 116,259 1p Ord.
                      shares
       24 June 2005   88(2) Return of Allotment of   Allotment 97,606 1p Ord.
                      shares
       17 June 2005   88(2) Return of Allotment of   Allotment 533,676 1p Ord.
                      shares
        3 June 2005   88(2) Return of Allotment of   Allotment 256,737 1p Ord.
                      shares
        3 June 2005   88(2) Return of Allotment of   Allotment 146,428 1p Ord.
                      shares
         9 May 2005   88(2) Return of Allotment of   Allotment 437,827 1p Ord.
                      shares
         9 May 2005   88(2) Return of Allotment of   Allotment 121,739 1p Ord.
                      shares
      15 April 2005   88(2) Return of Allotment of   Allotment 1,214,280 1p
                      shares                         Ord.
       4 March 2005   88(2) Return of Allotment of   Allotment 190,802 1p Ord.
                      shares

Copies of documents filed at Companies House can be obtained from Companies
House, Crown Way, Cardiff CF14 3UZ or through Companies House Direct at
www.direct.companieshouse.gov.uk

3. Documents published or sent to shareholders or filed with the UKLA Viewing
Facility

Date                  Description
--------------------- -------------
6 April 2006          Annual Report - year ended 31 December 2005 and Notice of 
                      Annual General Meeting
16 November 2005      Placing and Open Offer, Subscription, and Notice of 
                      Extraordinary General Meeting
30 September 2005     Interim Report for 6 months to 30 June 2005
29 March 2005         Annual Report - year ended 31 December 2004 and Notice of 
                      Annual General Meeting

Copies of all the above documents may be obtained from the Company Secretary at
the Company's Registered Office:

Oxford BioMedica plc
Medawar Centre
Robert Robinson Avenue
The Oxford Science Park
Oxford
OX4 4GA

11 April 2006



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