Holding(s) in Company

Intl. Biotechnology Trust PLC
28 February 2008

For filings with the FSA include the annex

For filings with issuer exclude the annex



TR-1: Notifications of Major Interests in Shares



1. Identity of the issuer or the underlying issuer of existing shares to which
voting rights are attached:



International Biotechnology Trust Plc



2. Reason for the notification

(please place an X inside the appropriate bracket/s):



An acquisition or disposal of voting rights: (X)



An acquisition or disposal of financial instruments which may result in the
acquisition of shares already issued to which voting rights are attached: (   )



An event changing the breakdown of voting rights: (   )



Other (please specify) : (   )

.................



3. Full name of person(s) subject to notification obligation:



AXA S.A 25 Avenue Matignon, 75008 Paris and its group of companies



4. Full name of shareholder(s) (if different from 3) :

.................



5. Date of transaction (and date on which the threshold is crossed or reached if
different):



21/02/2008



6. Date on which issuer notified:



22/02/2008



7. Threshold(s) that is/are crossed or reached:



5%




8. Notified Details:



A: Voting rights attached to shares


Class/type of shares if possible              Situation previous to the triggering transaction
use ISIN CODE
                                  Number of shares                   Number of voting rights


0455934                           3,531,281                          3,531,281



Resulting situation after the triggering transaction


Class/type of shares              Number of shares             Number of voting rights            % of voting rights

if possible use ISIN CODE
                                                            Direct            Indirect           Direct      Indirect


                                      3,511,080           3,511,080              0                4.97         0.00



B: Financial Instruments

Resulting situation after the triggering transaction


Type of         Expiration date      Exercise/conversion       No. of voting rights that   % of voting rights
financial                            period/date               may be acquired (if the
instrument                                                     instrument exercised/
                                                               converted)

N/A



Total (A+B)
Number of voting rights        % of voting rights


3,511,080                      4.97%



9. Chain of controlled undertakings through which the voting rights and/or the
financial instruments are effectively held, if applicable :

.................



Proxy Voting:



10. Name of proxy holder:

.................



11. Number of voting rights proxy holder will cease to hold:

.................



12. Date on which proxy holder will cease to hold voting rights:

.................



13. Additional information:

.................



14. Contact name:



John Spedding



15. Contact telephone number:



020 7658 3206




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