Holding in Company

Intl. Biotechnology Trust PLC
22 January 2001


Letters to Company Announcements

                    SUBSTANTIAL SHARE INTEREST NOTIFICATION

We are writing to advise you that the Company was notified on 17 January 2001,
that following the recent Tender Offer Co-operative Insurance Society Limited
has increased its beneficial interest in the Company, and now has an interest in
8,098,967 ordinary shares of 25p each, representing 16.66% of the 48,615,467
ordinary shares in issue.


                    SUBSTANTIAL SHARE INTEREST NOTIFICATION

We are writing to advise you that the Company was notified on 19 January 2001,
that following the Tender Offer Rothschild Asset Management Limited has ceased
to have a beneficial interest in the issued share capital of the Company.


                    SUBSTANTIAL SHARE INTEREST NOTIFICATION

We are writing to advise you that the Company was notified on 16 January 2001,
that following the recent Tender Offer AXA Investment Managers UK Limited has
decreased its beneficial interest in the Company, and now has an interest in
3,372,656 ordinary shares of 25p each, representing 6.94% of the 48,615,467
ordinary shares in issue.


                    SUBSTANTIAL SHARE INTEREST NOTIFICATION

We are writing to advise you that the Company was notified on 17 January 2001,
that following acceptance of the Company's Tender Offer, Charlamont Trading
Limited has ceased to have an interest in the issued share capital of the
Company and in consequence Quantum Partners and Quantum Endowment Fund NV have
also ceased to hold an interest in the shares.

Letters from  Schroder Investment Management Ltd on behalf of 
              International Biotechnology Trust plc