Final Results

RNS Number : 3524Z

GlaxoSmithKline PLC

05 February 2014

 



Issued: Wednesday, 5 February 2014, London U.K. Unaudited Preliminary Results Announcement for the year ended 31 December 2013 GSK delivers 2013 core EPS of 112.2p (+4% CER) and dividend of 78p (+5%)

Core results*
		2013	Growth		Q4 2013	Growth
		£m	CER%	£%	£m	CER%	£%
Turnover		26,505	1	-	6,906	5	2
Core operating profit		8,015	-	(3)	2,088	(1)	(8)
Core earnings per share		112.2p	4	1	30.1p	1	(7)

Total results
		2013	Growth		Q4 2013	Growth
		£m	CER%	£%	£m	CER%	£%
Turnover		26,505	1	-	6,906	5	2
Operating profit		7,028	(1)	(4)	2,441	36	27
Earnings per share		112.5p	27	23	51.3p	>100	>100

Summary
	·		GSK delivers 2013 reported turnover of £26.5 billion, up 1% (CER), and core EPS of 112.2p, up 4% (CER), in line with financial guidance
	·		£5.2 billion of cash returned to shareholders through 5% increase in 2013 dividend to 78p, (Q4 23p) and repurchase of £1.5 billion of shares
	·		Exceptional year for R&D delivery with approvals for 6 major products and 5 additional regulatory filings completed, helping to drive continued improvement in estimated R&D internal rate of return to 13%
	·		New product launches strengthen businesses in Respiratory, Vaccines, HIV and Oncology.  Around 30 brand innovations/extensions expected in Consumer Healthcare in 2014
	·		Expanding respiratory portfolio with 2 significant recent approvals and 7 potential new products in late-stage development provides platform to maintain market leadership to 2020 and beyond
	·		Pipeline opportunity remains substantial with Phase III data for 6 potential new drugs and vaccines and around 10 NME Phase III starts across 2014 and 2015
	·		Portfolio re-shaping continues with £2.5 billion raised from divestments completed in 2013 to increase focus of Consumer Healthcare and Pharmaceutical businesses.  New Established Products Portfolio provides further opportunities to optimise value
	·		Operating and financial efficiencies driving EPS leverage.  Year-on-year cost savings of around £400 million delivered in 2013 with similar amount expected in 2014 helping to offset mix pressure and fund ongoing investment requirements
	·		Continued strong cash generation, with adjusted net cash inflow from operating activities of £7.3 billion (+5%)
	·		Expect 2014 core EPS growth of 4 to 8% CER, on turnover growth of around 2% CER, on an ex-divestment basis (2013 EPS base 108.4p)

The full results are presented under 'Income Statements' on page 29 and Core results reconciliations are presented on pages 45 to 48. *   For explanations of the measures 'Core results', 'Adjusted net cash inflow from operating activities' and 'CER', see page 27.

GSK's strategic priorities

We have focused our business around the delivery of three strategic priorities, which aim to increase growth, reduce risk and improve our long term financial performance:
·	Grow a diversified global business
·	Deliver more products of value
·	Simplify the operating model

Chief Executive Officer's review

GSK's performance in 2013 represented further strong delivery for the Group.  We met our guidance with core EPS growth of 4% and sales growth of 1% (+3% ex-divestments) and returned £5.2 billion to shareholders via further growth in the dividend and our continuing share buy-back programme.  We also delivered the most productive period of R&D output in the Company's history and led the sector for new medicine approvals. Of the 6 major new medicine files we profiled at the start of 2013, 5 have been approved: Breo and Anoro for respiratory disease, Tafinlar and Mekinist for melanoma and Tivicay for HIV and we are expecting regulatory decisions for albiglutide, the remaining asset in this group, in the first half of 2014.  In addition, we launched our new injectable quadrivalent flu vaccine in the US.  Overall, GSK accounted for 19% of FDA new drug approvals during 2013 and since 2009 we have achieved more NME approvals in the United States than any other company. The conversion of our advanced pipeline to approved products represents the next key step in our strategy to deliver sustainable organic growth and value to shareholders.  The products we are currently launching will strengthen our existing businesses in Respiratory, Vaccines and support new growth in HIV and Oncology.  While achievement of market access in the current pharmaceutical environment is clearly slower than it was in the past, we are pleased with the early indicators of progress for our new launches.  Physician response to Tivicay has been extremely positive and the product has achieved rapid uptake in the US with more than 1,700 prescriptions filled during the 23rd week on the market, a trend on pace with the best recent launches in the HIV space.  As a result of this successful early launch of Tivicay we now believe ViiV Healthcare is at an inflection point and we expect this business to return to growth in 2014.  Our melanoma products Mekinist and Tafinlar already have around 60% combined share of prescriptions in the v600 targeted therapy market in the US.  The products were approved for use in combination in January and we also received FDA Breakthrough Designation for Tafinlar in non-small cell lung cancer in the same month. For Breo Ellipta in the US we have continued to build coverage with recent significant gains.  66% of patients insured through commercial plans and 25% of Medicare Part D patients now have unrestricted access to Breo and 90% of surveyed physicians are aware of the product.  We are also preparing to launch Anoro in the US, which will take us into the COPD bronchodilator market with the first dual agent available in the US.  With Advair, Flovent, Ventolin, Breo, Anoro and 7 other respiratory products in late stage development we are confident in the strength and future prospects of this broader portfolio of products and in our ability to maintain our leadership in respiratory well into the next decade. Our pipeline remains extensive.  We have around 40 NMEs in Phase II/III clinical development.  In 2014 and 2015 we expect Phase III read-outs for 6 NMEs and are planning Phase III starts for around 10 new products in key areas such as respiratory, oncology and immuno-inflammation.  This is in line with our strategic approach of a continued flow of multiple product launches which will help us drive future competitive advantage by diversifying our portfolio and reducing reliance on any one drug. Our DPU based discovery research strategy is also continuing to progress very well.  I am delighted with the sustained improvement in both quality of our compounds and more especially the research areas currently being prospected.  Our work in areas such as immuno-inflammation, antibody platforms, epigenetics and heart failure is particularly encouraging. The combination of innovation, effective asset progression and successful approvals with reductions in R&D spend has led to a further improvement in the estimated IRR of our R&D investments to 13%.  We continue to target 14% on a longer-term basis. This improvement in IRR is an important measure of our financial discipline and our strategic progress to improve the economics of research and development.  It also underpins our strategy to create more flexibility around the pricing of our new medicines to meet the needs of payers and governments. GSK's trading performance in 2013 was in line with our guidance, despite some unexpected challenges and reflected the improving balance of our sales base.  I was encouraged by the improved performance of our US business (+1%, +4% excluding Vesicare divestment).  We also saw stabilisation of our European business (flat sales) with the benefits of our restructuring programme helping to offset the ongoing economic and pricing pressures in the region.   We are committed to investing behind continuing growth in our important Emerging Markets business.  Sales in the region were up 5% for the year and 11% in the fourth quarter, excluding the impact of the ongoing investigation by the Chinese authorities.  During the year, we also took steps to increase our equity holdings in our fast-growing Indian pharmaceuticals and consumer subsidiaries and announced plans to build new manufacturing capacity in the country. Increasing focus and investment around our core businesses is driving enhanced performance.  Over the last two years we have taken steps to streamline our Consumer product portfolio and we have divested more than 50 non-core products, including, last year, Lucozade and Ribena for £1.35 billion.  Consumer Healthcare grew 4% excluding divested brands with growth across all regions. In Pharmaceuticals, last year we divested our anti-coagulant products for more than £700 million.  With our newly formed Established Products Portfolio (EPP), we see more opportunities to reduce complexity, enhance profitability and optimise the value of this group of products. Operationally, we continue to restructure and simplify our business to reduce our long term cost base.  In 2013 we delivered incremental year-on-year savings of around £400 million from both ongoing and structural initiatives.  We are particularly focusing on the efficiency of our commercial organisation as well as standardisation of enterprise-wide platforms including IT and procurement.  This is creating greater flexibility to allocate resources behind our growth markets and new product launches.  Together with continued improvement in our financial efficiency, this strengthens our ability to deliver earnings per share growth ahead of sales.   For 2014, we are targeting core earnings per share growth of 4-8% CER on sales growth of around 2% CER on an ex-divestment basis.  The range in our guidance reflects the transition we expect to see in our portfolio during the year as we roll-out new products but also face potential competition from generics to older products such as Lovaza.  The business remains highly cash generative and we continue to focus on improving conversion of earnings into cash.  We generated £4.8 billion in adjusted free cash flow in 2013.  In addition, we realised £2.5 billion from divestments leaving net debt at the end of the year at £12.6 billion.  This gives us the flexibility we need to protect our credit profile and fund organic investment and restructuring programmes as well as our ongoing commitment to a growing dividend, further share buy-backs and bolt-on acquisitions whichever offers the most attractive return.  Based on current market conditions we are targeting share repurchases of £1-2 billion in 2014. Looking further ahead, we continue to make fundamental changes to our business, including how we interact with our customers; investments in technologies to support research and manufacturing; new policies to determine the pricing and value of our products, and in the culture of our organisation.  We believe these changes are vital in an industry with a 20-year business cycle and which operates in an environment as dynamic and as challenging as global healthcare. I would like to thank all our employees, partners and suppliers for their continued commitment and support.  Our continued aim is to deliver innovation and access to our products for patients and customers, and improved, sustainable financial performance for our shareholders.

Sir Andrew Witty Chief Executive Officer

Presentations of today's results are available on www.gsk.com

All forward looking statements are based on 2013 core numbers adjusted to exclude divestments, at CER and barring unforeseen circumstances.  See 'Cautionary statement regarding forward-looking statements' on page 27.

Contents	Page
2013 results summary	1
Chief Executive Officer's review	2
Group performance	5
Divisional performance	15
Research and development	23
Definitions	27
Contacts	28
Income statements	29
Statement of comprehensive income	30
Pharmaceuticals and Vaccines turnover - year ended 31 December 2013	32
Pharmaceuticals and Vaccines turnover - three months ended 31 December 2013	33
ViiV Healthcare turnover - twelve months and three months ended 31 December 2013	34
Balance sheet	35
Statement of changes in equity	36
Cash flow statement - 2013	37
Segment information	38
Legal matters	41
Taxation	41
Additional information	42
Reconciliation of cash flow to movements in net debt	44
Core results reconciliations	45
Group reporting in 2014	49

Group performance

Group turnover by division, geographic region and segment

Group turnover by division	2013		Q4 2013
	-----------------------------------		-----------------------------------
	£m	Growth CER%	£m	Growth CER%
	------------	------------	------------	------------
Pharmaceuticals	17,898	1	4,721	5
Vaccines	3,420	2	967	12
	------------	------------	------------	------------
Pharmaceuticals and Vaccines	21,318	1	5,688	6
Consumer Healthcare	5,187	2	1,218	-
	------------	------------	------------	------------
	26,505	1	6,906	5
	------------	------------	------------	------------

Group turnover by geographic region	2013		Q4 2013
	-----------------------------------		-----------------------------------
	£m	Growth CER%	£m	Growth CER%
	------------	------------	------------	------------
US	8,730	2	2,272	6
Europe	7,511	(1)	1,900	(2)
EMAP	6,746	2	1,755	5
Japan	1,890	2	525	16
Other	1,628	4	454	16
	------------	------------	------------	------------
	26,505	1	6,906	5
	------------	------------	------------	------------
Group turnover outside US and Europe	10,264	2	2,734	9
	------------	------------	------------	------------

Group turnover by segment		2013		Q4 2013
		-----------------------------------		-----------------------------------
		£m	Growth CER%	£m	Growth CER%
		------------	------------	------------	------------
Pharmaceuticals and Vaccines
-	US	7,192	1	1,850	5
-	Europe	5,166	-	1,330	(2)
-	EMAP	4,698	1	1,306	5
-	Japan	1,657	1	467	17
-	ViiV Healthcare	1,386	-	385	15
-	Other trading and unallocated pharmaceuticals	1,219	5	350	19
		------------	------------	------------	------------
Pharmaceuticals and Vaccines		21,318	1	5,688	6
Consumer Healthcare		5,187	2	1,218	-
		------------	------------	------------	------------
		26,505	1	6,906	5
		------------	------------	------------	------------

Turnover - 2013 Total Group turnover for 2013 was £26,505 million, up 1%.  Excluding the impact of disposals, primarily the conclusion of the Vesicare co-promotion agreement in the US in Q1 2012 and the non-core OTC brands divested in H1 2012, turnover grew 3%.  Reported Pharmaceuticals and Vaccines turnover grew 1% and excluding disposals, grew 2%.  Pharmaceuticals turnover grew 1% and, excluding disposals, grew 2%, as growth in the US, Japan and EMAP was partially offset by continued pricing pressures and generic competition in Europe. ViiV Healthcare turnover for 2013 was flat.  Vaccines turnover grew 2%, despite the adverse comparison with strong Cervarix sales in Japan in 2012.  Excluding Cervarix in Japan, Vaccines sales grew 5%, reflecting the strong growth in the US of Infanrix/Pediarix and Boostrix, both of which benefited from competitor supply issues, and Fluarix/FluLaval, which benefited from the launch of the new Quadrivalent formulation, as well as a better performance by the business in Europe.  Consumer Healthcare turnover increased 2% to £5,187 million, but excluding the non-core OTC brands divested in H1 2012, turnover grew 4%. In the US, Pharmaceuticals and Vaccines turnover was up 1%, but grew 4% excluding the impact of the conclusion of the Vesicare co-promotion agreement in Q1 2012.  Pharmaceuticals turnover was down 1% but excluding Vesicare, grew 2%.  Sales of Respiratory products grew 7% to £3,655 million, led by an 8% growth in Advair, although this performance included the benefit of favourable stocking patterns in the fourth quarter.  Oncology products also performed well, growing 17% to £380 million, led by strong performances from Votrient and Promacta and the initial impact of the launches of Tafinlar and Mekinist monotherapies during the year.  Benlysta sales more than doubled to £134 million.  These gains were partially offset by the impact of generic competition to Lamictal, down 18% to £276 million, and a number of Dermatology products, down 40% to £140 million.  The 17% increase in Vaccines sales primarily resulted from the increases in Infanrix/Pediarix sales of 23% to £271 million and Boostrix sales of 23% to £183 million, both of which benefited from competitor supply shortages.  Fluarix/FluLaval sales were also strong, up 65% to £146 million, following the launch of the Quadrivalent flu formulation in 2013. Europe Pharmaceuticals and Vaccines turnover was £5,166 million, flat compared with 2012, as the benefits of the recent restructuring and refocusing of the business were offset by continued pricing pressures and generic competition to a number of products.  Pharmaceutical sales were down 1% to £4,117 million.  Seretide sales declined 2% to £1,458 million on a 2% volume decline but flat pricing.  Oncology products, particularly Votrient and Promacta, performed well, as did Avodart, but growth from these products was more than offset by lower sales of a number of older products, which were particularly impacted by continued pricing measures and generic competition.  Vaccines sales grew 3%, largely due to an improved tender performance. EMAP Pharmaceuticals and Vaccines turnover was up 1% to £4,698 million in 2013, adversely affected by the ongoing investigation in China, with Pharmaceuticals up 2% to £3,574 million and Vaccines up 1% to £1,124 million.  In China, Pharmaceuticals and Vaccines sales were down 18%, driven primarily by declines in Respiratory and Hepatitis products.  Excluding China, EMAP Pharmaceuticals and Vaccines sales grew 5% driven by Pharmaceuticals growth in the Middle East/Africa, up 5% to £1,018 million, Latin America, up 6% to £650 million, and South East Asia, up 4% to £257 million, partially offset by declines in India, down 7% to £220 million, and Korea, down 4% to £200 million.  Vaccines sales were up 1% to £1,124 million, and up 3% excluding China, reflecting strong tender performances from Cervarix and Infanrix/Pediarix, which were partially offset by a tough comparison with 2012. Japan Pharmaceuticals and Vaccines turnover grew 1% to £1,657 million, as a 9% growth in Pharmaceuticals sales was partially offset by a 76% decline in Vaccines sales.  Strong growth in Respiratory products as well as for Relenza, Avodart and Lamictal was partly offset by generic competition to Paxil sales.  Vaccines sales primarily reflected the impact on Cervarix of the suspension of the recommendation for the use of HPV vaccines in Japan during the second half of 2013 and the adverse comparison with 2012, which benefited from the final stages of the catch-up HPV vaccination programme. ViiV Healthcare turnover was flat at £1,386 million as the growth generated by Epzicom and Selzentry, together with the introduction of Tivicay, was offset by the impact of continued competition to older products. Consumer Healthcare turnover, excluding the non-core OTC brands divested in H1 2012, grew 4%, with growth in all four categories.  Growth in the US, up 2%, and Europe, up 3%, primarily arose from Specialist oral health, including Sensodyne, Denture care and the re-stocking of alli, which was out of stock for much of 2012.  Rest of World turnover grew 6% with strong growth in India, the Middle East and Latin America partly offset by a decline in sales in China, driven by the impact of the shelving restrictions on Contac and mandatory price reductions for Fenbid.  Reported Consumer Healthcare turnover grew 2% to £5,187 million.

Turnover - Q4 2013 Total Group turnover for Q4 2013 was £6,906 million, up 5%, with growth across all geographic regions except Europe, which was down 2%.  Disposals did not materially affect the reported growth rate for the Group in the quarter.  Pharmaceuticals and Vaccines turnover was up 6%.  Pharmaceuticals turnover grew 5%, as higher sales in the US, Japan and ViiV Healthcare were partly offset by a decline in sales in Europe and EMAP.  Vaccines turnover grew 12%, as strong performances in the US and EMAP were partially offset by lower sales in Japan.  Consumer Healthcare turnover was flat at £1,218 million. In the US, Pharmaceuticals and Vaccines turnover grew 5% to £1,850 million, with Pharmaceuticals up 3% and Vaccines up 23%.  Pharmaceuticals and Vaccines turnover in the quarter benefited from re-stocking by wholesalers and retailers from the low levels seen during earlier periods of the year.  This re-stocking, together with the positive impact of a comparison with relatively weak Q4 2012 stocking patterns, is estimated to have benefited reported turnover growth by approximately 5 percentage points, largely in Respiratory.  The underlying performance of US Pharmaceuticals and Vaccines sales primarily reflected volume declines in Respiratory products and Lovaza, offset by price and mix benefits although pricing pressures in the market remain significant.  Reported sales of Advair were up 17%, particularly benefiting from the wholesaler and retailer stocking movements.  The launch of Breo Ellipta began in the quarter and recorded sales of £6 million.  Oncology products contributed strongly to the quarter, with sales up 21% to £102 million, benefiting from strong performances from Votrient and Promacta, and the recent launches of Tafinlar and Mekinist.  Benlysta also reported strong growth, with sales up 26% to £33 million.  Reported Lovaza sales fell 5% to £139 million, due to increased competition as well as a slower overall market.  Generic competition impacted Lamictal, Arixtra and Dermatology products.  The 23% increase in Vaccines sales primarily reflected the benefit of the launch of the new Quadrivalent flu formulation and a 97% increase in Boostrix sales to £65 million, which benefited from a competitor supply shortage. Europe Pharmaceuticals and Vaccines turnover fell 2% to £1,330 million.  Pharmaceutical sales fell 2% to £1,055 million, reflecting continued pricing pressures and generic competition to a number of older products, partially offset by benefits arising from the recent restructuring and refocusing of the business.  Seretide sales declined 4% to £368 million, with volumes down 5% partially offset by a 1% positive impact of price and mix.  Strong growth in Oncology, up 26% to £89 million, was led by Votrient and Promacta, together with the initial stages of the Tafinlar launch.  Sales of Avodart increased 13% to £72 million.  Vaccines sales were flat, reflecting an adverse comparison with a strong Q4 2012, which benefited from some competitor supply issues. EMAP Pharmaceuticals and Vaccines turnover increased 5% to £1,306 million, reflecting the net impact of the ongoing investigation in China offset by favourable vaccine tender phasing.  Pharmaceuticals were down 1% and Vaccines up 22%.  Excluding China, EMAP Pharmaceuticals and Vaccines sales grew 11%.  In China, Pharmaceuticals and Vaccines sales were down 29% with Hepatitis and Respiratory products continuing to be particularly affected.  Excluding China, EMAP Pharmaceuticals turnover grew 6% with continued strong growth from Seretide, up 17%, Avodart, up 43% and Oncology, up 16%.  Augmentin grew 5%.  There were strong contributions from Middle East/Africa, Latin America and North Asia.  Vaccines sales were up 22% to £389 million, despite some supply disruptions during the quarter, largely reflecting the phasing of tenders, with strong tender deliveries, particularly of Synflorix in Brazil, and Fluarix/Flulaval in China and Latin America. Japan Pharmaceuticals and Vaccines turnover grew 17% to £467 million in the quarter, with Pharmaceuticals sales increasing 19% and Vaccines sales declining by 44%.  The growth in Pharmaceuticals reflected particularly strong sales of Respiratory products, up 12%, particularly Adoair, up 11%, and Xyzal, up 19%, together with tender shipments of Relenza.  Relvar was launched in the quarter.  Lamictal grew 26% and Avodart was up 25%, partially offset by a 9% decline in Paxil sales.  The decline in Vaccines sales reflected the impact on Cervarix of the suspension of the positive recommendation for use of HPV vaccines in Japan. ViiV Healthcare turnover grew 15% to £385 million, including a favourable adjustment to US accruals for returns and rebates.  The growth generated by Epzicom and the recent launch of Tivicay was partially offset by the impact of continued competition to older products and the phasing of tenders. Consumer Healthcare turnover was flat, but grew 1% excluding disposals made in 2012.  US turnover fell 2% as a strong performance from Sensodyne was offset by decreases in Total wellness sales, impacted by stocking patterns and some supply disruptions.  The 4% decline in Europe turnover was also affected by wholesaler and retailer stocking patterns but also some supply interruptions, particularly for Aquafresh.  Rest of World turnover grew 5%, with strong growth in India, Japan, Middle East and Latin America partly offset by the continuing impact in China of the new shelving requirements for Contac and mandatory price reductions for Fenbid.

Core operating profit and margin

Core operating profit	2013			Q4 2013
	-------------------------------------------------------			-------------------------------------------------------
	£m	% of turnover	Growth CER %	£m	% of turnover	Growth CER %
	------------	------------	------------	------------	------------	------------
Turnover	26,505	100	1	6,906	100	5
Cost of sales	(7,549)	(28.5)	6	(2,006)	(29.0)	10
Selling, general and administration	(7,928)	(29.9)	1	(2,005)	(29.0)	6
Research and development	(3,400)	(12.8)	(3)	(905)	(13.1)	9
Royalty income	387	1.4	25	98	1.3	28
	------------	------------	------------	------------	------------	------------
Core operating profit	8,015	30.2	-	2,088	30.2	(1)
	------------	------------	------------	------------	------------	------------
Core profit before tax	7,366		-	1,944		1
Core profit after tax	5,671		2	1,513		1
Core profit attributable to shareholders	5,421		2	1,444		-
	------------			------------
Core earnings per share	112.2p		4	30.1p		1
	------------		------------	------------		------------

Core operating profit by division	2013			Q4 2013
	-------------------------------------------------------			-------------------------------------------------------
	£m	Margin %	Growth CER %	£m	Margin %	Growth CER %
	------------	------------	------------	------------	------------	------------
Pharmaceuticals	6,633	37.1	3	1,774	37.6	13
Vaccines	1,096	32.0	(8)	309	32.0	13
	------------	------------	------------	------------	------------	------------
Pharmaceuticals and Vaccines	7,729	36.3	1	2,083	36.6	13
Consumer Healthcare	913	17.6	3	225	18.5	5
	------------	------------	------------	------------	------------	------------
	8,642		2	2,308		12
Corporate & other unallocated costs	(627)		30	(220)		>100
	------------	------------	------------	------------	------------	------------
Core operating profit	8,015	30.2	-	2,088	30.2	(1)
	------------	------------	------------	------------	------------	------------

Core operating profit by segment		2013			Q4 2013
		-------------------------------------------------------			-------------------------------------------------------
		£m	Margin %	Growth CER %	£m		Margin %	Growth CER %
		------------	------------	------------	------------		------------	------------
Pharmaceuticals and Vaccines
-	USA	4,993	69.4	3	1,285	69.5		7
-	Europe	2,829	54.8	3	697	52.4		(2)
-	EMAP	1,468	31.2	(3)	473	36.2		6
-	Japan	978	59.0	4	299	64.0		27
-	ViiV Healthcare	885	63.9	3	223	57.9		26
-	Pharmaceutical R&D	(2,823)		1	(735)			5
-	Other trading and unallocated    pharmaceuticals	(601)	(49.3)	31	(159)	(45.4)		(33)
		------------	------------	------------	------------	------------		------------
Pharmaceuticals and Vaccines		7,729	36.3	1	2,083	36.6		13
Consumer Healthcare		913	17.6	3	225	18.5		5
		------------	------------	------------	------------	------------		------------
		8,642		2	2,308			12
Corporate & other unallocated costs		(627)		30	(220)			>100
		------------	------------	------------	------------	------------		------------
Core operating profit		8,015	30.2	-	2,088	30.2		(1)
		------------	------------	------------	------------	------------		------------

Core operating profit - 2013 Core operating profit was £8,015 million, flat in CER terms on a turnover increase of 1%.  The core operating margin of 30.2% was 1.0 percentage points lower than in 2012.  Excluding currency effects, the margin declined 0.5 percentage points.  This reflected the negative impact of an expected increase in cost of sales, partially offset by higher royalty income and lower R&D expenditure, as the Group's continuing restructuring programmes contributed incremental year-on-year savings of around £400 million from both ongoing and structural initiatives.  The contribution in 2013 from structural benefits was approximately £115 million lower than in 2012.  Total savings realised from the previously announced changes to post-retirement medical obligations in 2013 were approximately £280 million, after final adjustments made during the fourth quarter.  In 2012, the Group realised £395 million of savings from the capping of future pensionable salary increases and a change in the basis of future discretionary pension increases from RPI to CPI in certain legacy plans. Cost of sales was 28.5% of turnover compared with 26.9% in 2012.  Net of currency effects of 0.3 percentage points and the impact of a 0.3 percentage point reduction to the 2012 cost of sales percentage due to the settlement in H1 2012 of a royalty agreement and the conclusion of the Vesicare agreement, the cost of sales percentage increased 1.0 percentage points.  This reflected the expected impact of the unwinding of costs of manufacturing volume shortfalls, adverse mix and the impact of preparing for the launches of new pipeline products, partially offset by ongoing cost management, better price realisation and restructuring benefits. SG&A costs as a percentage of sales were 29.9%, flat on 2012, as the net favourable year-on-year benefits of the Group's restructuring programmes and ongoing cost management efforts funded investments in growth businesses and preparations for new product launches. R&D expenditure declined 3% to £3.4 billion (12.8% of turnover) compared with £3.5 billion (13.2% of turnover) in 2012.  This reflected the completion of a number of large trials, the phasing of ongoing project spending as well as continuing cost management.  In 2014, core R&D expenditure is expected to remain broadly stable at around £3.5 billion in aggregate. Royalty income was £387 million (2012: £306 million) and included a prior year royalty catch-up adjustment recorded in Q1 2013.  Following conclusion of a number of royalty agreements in the year, royalty income is likely to be lower in 2014 at around £300 million. Core operating profit - Q4 2013 Core operating profit was £2,088 million, a 1% decrease on a turnover increase of 5% CER.  Compared with Q4 2012, the core operating margin decreased by 3.1 percentage points to 30.2%.  Excluding currency effects, the operating margin decreased by 1.8 percentage points, reflecting lower restructuring and operating efficiency benefits compared with Q4 2012, which included the delivery in that quarter of pension savings of £290 million.  This impact was partially offset by growth in SG&A below turnover growth, a decline in R&D expenditure and higher royalty income. Cost of sales was 29.0% of turnover compared with 27.0% in Q4 2012, with 0.8 percentage points of the increase due to currency translation.  Excluding currency effects, the cost of sales percentage increased 1.2 percentage points, reflecting the benefit of the pension restructuring in Q4 2012, higher stock write-offs and the expected impact of the unwinding of prior year costs of manufacturing volume shortfalls, partly offset by ongoing cost management, better pricing and restructuring benefits. SG&A costs as a percentage of sales were 29.0% compared with 28.5% in Q4 2012.  Excluding currency effects, SG&A increased 0.4 percentage points, reflecting the benefit of the pension restructuring in Q4 2012, as well as continued investments in growth businesses and new product launches partly offset by restructuring benefits and ongoing cost management. R&D expenditure increased 9% to £905 million (13.1% of turnover) compared with £837 million in Q4 2012 (12.3% of turnover) reflecting the benefit of the pension restructuring in Q4 2012, and the phasing of ongoing project spending, offset by completion of a number of programmes and continuing cost management. Royalty income was £98 million (Q4 2012: £76 million). Core profit after tax and core earnings per share - 2013 Net finance expense was £692 million compared with £724 million in the twelve months to December 2012, despite higher average net debt levels during the year, reflecting GSK's strategy to improve the funding profile of the Group.  Net debt at 31 December 2013 was £1.4 billion lower than at 31 December 2012, reflecting receipts of £2.5 billion from the disposals of businesses, intangible assets, Aspen shares and other investments during the year. Tax on core profit amounted to £1,695 million and included recognition of US R&D credits reflected in the effective core tax rate of 23.0% (2012: 24.4%).  The core tax rate for 2014 is expected to be around 22%. Core EPS of 112.2p increased 4% in CER terms and 1% at actual exchange rates. Core profit after tax and core earnings per share - Q4 2013 Net finance expense was £155 million (Q4 2012: £194 million) despite an increase in average net debt compared with Q4 2012.  Net debt decreased by £2.4 billion in the quarter, primarily due to receipts of £2.3 billion from the disposals of businesses, intangible assets, Aspen shares and other investments during the quarter. Tax on core profit amounted to £431 million and reflected an effective core tax rate of 22.2% (Q4 2012: 22.2%). Core EPS of 30.1p increased 1% in CER terms but declined 7% at actual exchange rates due to the impact of currencies on the translation of overseas results.

Revision of IAS 19 'Employee benefits' IAS 19 (Revised) has been implemented by GSK from 1 January 2013.  The main effect is that the expected returns on pension scheme assets have been replaced by income calculated using the same discount rate as that used to measure the pension obligations.  This discount rate is based on market rates for high quality corporate bonds.  As a consequence, pension scheme costs in the income statement are higher under IAS 19 (Revised) and this impacted 2013 core operating profit by approximately £160 million and core EPS by 2.5p.  Core operating profit for Q4 2013 was impacted by £40 million and core EPS by 0.7p.  The results for 2012 have been restated, and the effect of the change on 2012 results was to reduce core operating profit for the year by £92 million and for Q4 2012 by £23 million and core EPS for the year by 1.3p and the quarter by 0.4p.

Outlook for 2014 In 2014, GSK expects core EPS growth of 4-8% CER (from 2013 base of 108.4p adjusted for divestments completed during 2013) on turnover growth of around 2% CER (from 2013 base of £25,602 million adjusted for divestments completed during 2013).  See page 49 for more details.

Currency impact The 2013 results are based on average exchange rates, principally £1/$1.57, £1/€1.18 and £1/Yen 153.  Comparative exchange rates are given on page 42.  The period end exchange rates were £1/$1.66, £1/€1.20 and £1/Yen 174. In the year, turnover grew 1% CER and was flat at actual exchange rates.  Core EPS for the year of 112.2p was up 4% in CER terms and up 1% at actual rates.  The negative currency impact reflected the strengthening of Sterling against particularly the Japanese Yen but also a number of other currencies, partially offset by the weakening of Sterling against the US Dollar and the Euro.  Losses on settled intercompany transactions were £27 million in the year (2012: £26 million). Turnover in the quarter grew 5% in CER terms and 2% at actual rates.  Core EPS for the quarter was 30.1p, up 1% in CER terms and down 7% at actual rates as Sterling strengthened relative to a broad range of currencies, particularly the US Dollar but also the Yen.  Currencies in the EMAP region also saw weakness and, with the relatively lower proportion of the cost base in these countries, contributed to the greater adverse currency impact on EPS compared with that on sales. Average rates for January were £1/$1.65, £1/€1.21 and £1/Yen 171.  If exchange rates were to hold at these rates for the rest of 2014, the estimated adverse impact on 2014 sterling turnover would be around 5%, and if there were no further exchange gains or losses, the estimated adverse impact on 2014 sterling core EPS would be around 6%.

Core adjustments The adjustments that reconcile core operating profit, profit after tax and earnings per share to total results are as follows:

	2013			2012
	------------------------------------------------------------			------------------------------------------------------------
	Operating profit £m	Profit after tax £m	EPS p	Operating profit (restated) £m	Profit after tax (restated) £m	EPS (restated) p
	------------	------------	------------	------------	------------	------------
Core results	8,015	5,671	112.2	8,238	5,705	111.4
Intangible asset amortisation	(547)	(398)	(8.2)	(477)	(332)	(6.8)
Intangible asset impairment	(739)	(513)	(10.7)	(693)	(497)	(7.3)
Major restructuring costs	(517)	(378)	(7.8)	(557)	(843)	(17.4)
Legal costs	(252)	(243)	(5.0)	(436)	(286)	(5.8)
Acquisition accounting and other	1,068	1,489	32.0	1,225	931	17.5
	------------	------------	------------	------------	------------	------------
	(987)	(43)	0.3	(938)	(1,027)	(19.8)
	------------	------------	------------	------------	------------	------------
Total results	7,028	5,628	112.5	7,300	4,678	91.6
	------------	------------	------------	------------	------------	------------

	Q4 2013			Q4 2012
	------------------------------------------------------------			------------------------------------------------------------
	Operating profit £m	Profit after tax £m	EPS p	Operating profit (restated) £m	Profit after tax (restated) £m	EPS (restated) p
	------------	------------	------------	------------	------------	------------
Core results	2,088	1,513	30.1	2,264	1,619	32.2
Intangible asset amortisation	(150)	(109)	(2.3)	(131)	(91)	(1.9)
Intangible asset impairment	(453)	(299)	(6.2)	(293)	(216)	(1.7)
Major restructuring costs	(175)	(67)	(1.4)	(245)	(597)	(12.3)
Legal costs	(89)	(106)	(2.2)	(91)	(94)	(1.9)
Acquisition accounting and other	1,220	1,573	33.3	413	202	3.1
	------------	------------	------------	------------	------------	------------
	353	992	21.2	(347)	(796)	(14.7)
	------------	------------	------------	------------	------------	------------
Total results	2,441	2,505	51.3	1,917	823	17.5
	------------	------------	------------	------------	------------	------------

Full reconciliations between core results and total results are set out on pages 45 to 48 and the definition of core results is set out on page 27.

Total operating profit and total earnings per share - 2013 Total operating profit was £7,028 million compared with £7,300 million in 2012.  The non-core items resulted in total net charges of £987 million in 2013 (2012: £938 million).  The intangible asset amortisation of £547 million (2012: £477 million) included £94 million related to the amortisation of the Benlysta intangible asset acquired as part of the HGS acquisition.  Intangible asset impairments of £739 million (2012: £693 million) included write-offs of several R&D assets, together with the partial impairment of Lovaza, reflecting a reassessment of the Group's expectations on the likelihood of potential generic competition. Major restructuring charges of £517 million (2012: £557 million) comprised £238 million under the Operational Excellence programme, £260 million under the Major Change programme and £19 million related to the acquisition of HGS.  The Major Change programme focuses on opportunities to simplify our supply chain processes, build the Group's capabilities in manufacturing and R&D, and restructure our European Pharmaceuticals business.  The programme is expected to cost £1.5 billion, of which the non-cash charge will be £350 million, and is expected to deliver annual pre-tax savings of at least £1.0 billion by 2016.  Legal charges of £252 million (2012: £436 million) principally related to provisions for existing product liability matters. Acquisition accounting and other credits of a net £1,068 million (2012: £1,225 million credit) included items related to major acquisitions, business, equity investment and asset disposals, one-off required regulatory charges in R&D and certain other adjusting items.  The 2013 net credit included gains on the disposals of the Lucozade and Ribena business and the anti-coagulant products of £1,331 million.  The 2012 net credit included gains on the profit on disposal of the non-core OTC brands of £559 million and the gain of £581 million arising on the revaluation of pre-existing collaborations as part of the HGS and ViiV Healthcare/Shionogi joint venture acquisitions. Total profit before tax also included the profit on disposal of associates and joint ventures of £282 million. The charge for taxation on total profits amounted to £1,019 million and represented a total effective tax rate of 15.3% (2012: 29.1%), reflecting the differing tax effects of the various non-core items.  It also included a net deferred tax charge of £234 million related to the unwinding of deferred profit in inventory as existing inventory produced prior to the 2012 restructuring of the supply chain is sold, offset by deferred tax credits of £393 million, primarily reflecting continuing restructuring of the supply chain.  See 'Taxation' on page 41. Total EPS was 112.5p for the year, compared with 91.6p in 2012 an increase of 20.9p.  Non-core items totalled a credit of 0.3p compared with charges of 19.8p in 2012. Total operating profit and total earnings per share - Q4 2013 Total operating profit was £2,441 million compared with £1,917 million in Q4 2012.  The non-core items resulted in total net credits of £353 million in the quarter (Q4 2012: charges of £347 million).  Intangible asset amortisation amounted to £150 million in the quarter (Q4 2012: £131 million).  Intangible asset impairments of £453 million (Q4 2012: £293 million) included write-offs of several R&D assets, together with the partial impairment of Lovaza. Major restructuring charges of £175 million (Q4 2012: £245 million) principally comprised £46 million under the Operational Excellence programme and £128 million under the Major Change programme. Legal charges were £89 million in the quarter (Q4 2012: £91 million). Acquisition accounting and other credits of £1,220 million (Q4 2012: £413 million) included items related to major acquisitions, business, equity investment and asset disposals, one-off required regulatory charges in R&D and certain other adjusting items.  The net credit in 2013 included profits on the disposal of businesses of £1,331 million (Q4 2012: £nil) arising from the disposals of the Lucozade and Ribena business and the anti-coagulant products.  The 2012 net credit included the gain of £348 million arising on the revaluation of the pre-existing collaboration as part of the ViiV Healthcare/Shionogi joint venture acquisition. The charge for taxation on total profits amounted to £41 million and represented a total effective tax rate of 1.6% (Q4 2012: 52.4%), reflecting the differing tax effects of the various non-core items, in particular the business disposal proceeds.  It also included a deferred tax credit following continuing restructuring of the supply chain, partially offset by a deferred tax charge of £41 million related to the unwinding of deferred profit in inventory, as existing inventory produced prior to the 2012 restructuring of the supply chain is sold.  See 'Taxation' on page 41. Total EPS was 51.3p for the quarter, compared with 17.5p in Q4 2012, an increase of 33.8p.  Non-core items totalled a credit of 21.2p (Q4 2012: charges of 14.7p).

Cash generation and conversion

Cash flow and net debt

	2013	2012	Q4 2013
	------------	------------	------------
Net cash inflow from operating activities (£m)	7,222	4,375	2,187
Adjusted net cash inflow from operating activities* (£m)	7,337	6,985	2,355
Free cash flow* (£m)	4,657	2,049	1,434
Adjusted free cash flow* (£m)	4,772	4,659	1,602
Free cash flow growth (%)	>100%	(51)%	37%
Free cash flow conversion* (%) (2012 - restated)	84%	97%	62%
Net debt (£m)	12,645	14,037	12,645
	------------	------------	------------
*  Adjusted net cash inflow from operating activities, free cash flow, adjusted free cash flow and free cash flow conversion are defined on page 27.

The net cash inflow from operating activities for the year was £7,222 million (2012: £4,375 million).  Excluding legal settlements (£115 million; 2012: £2,610 million), the adjusted net cash inflow from operating activities was £7,337 million (2012: £6,985 million), a 5% increase in sterling terms over 2012.  This primarily reflected phasing of restructuring expenditure, together with lower tax payments and pension contributions partially offset by a smaller reduction in working capital compared with 2012 given supply chain investments in inventory and launch preparation. Free cash flow was £4,657 million for the year.  Excluding legal payments, adjusted free cash flow was £4,772 million (2012: £4,659 million).  The increase on last year primarily reflecting the impact of lower tax payments and special UK pension contributions, partly offset by a smaller reduction in working capital and increased expenditure on property, plant and equipment.  The Group paid dividends to shareholders of £3,680 million, and spent £1,504 million on repurchasing shares. At 31 December, net debt was £12.6 billion, compared with £14.0 billion at 31 December 2012, comprising gross debt of £18.2 billion and cash and liquid investments of £5.6 billion.  The decrease in net debt reflected the receipts of £2.5 billion from the disposals of the Lucozade/Ribena and anti-coagulant products businesses, intangible assets, part of the Group's investment in Aspen Pharmacare Holdings Limited and other investments.  The impact of these was partly offset by the consideration paid to increase the shareholding in the Group's Indian Consumer Healthcare subsidiary from 43.2% to 72.5% at a cost of £588 million and to acquire Okairos AG for £205 million.  At 31 December 2013, GSK had short-term borrowings (including overdrafts) repayable within 12 months of £2,789 million with loans of £1,931 million repayable in the subsequent year. In the quarter, net cash inflow from operating activities was £2,187 million.  Excluding legal payments, the adjusted net cash inflow from operating activities was £2,355 million, a 15% increase in sterling terms over 2012.  This primarily reflected the lower tax payments and reduced UK special pension contributions, partly offset by a smaller reduction in working capital compared with Q4 2012.

Working capital

	31 December 2013	30 September 2013	30 June 2013	31 March 2013	31 December 2012
	------------	------------	------------	------------	------------
Working capital conversion cycle* (days)	176	201	198	203	194
Working capital percentage of turnover (%)	19	22	22	22	21
	------------	------------	------------	------------	------------
*  Working capital conversion cycle is defined on page 27.

The Group's working capital programme has continued to make progress with further improvements in the collection of receivables and more effective management of payables balances.  During the year a number of initiatives were implemented across the Group's supply chains supporting the Pharmaceutical, Vaccines and Consumer Healthcare businesses that have provided stronger end-to-end accountability in each case.  These programmes are at an early stage but have already reduced volatility and improved responsiveness allowing better inventory management.  The net impact on inventory has been limited in 2013 as significant investments have also been made in improving service levels and preparing for new product launches. The reported working capital conversion cycle days are distorted by divestments made during the year and the intangible asset impairments included in the denominator used in the conversion cycle computation.  The year-end 2013 and 2012 conversion cycles adjusted for these factors, were around 190 days and around 200 days, respectively, a reduction of 10 days.

Returns to shareholders

GSK's commitment is to use free cash flow to support increasing dividends, undertake share repurchases or, where returns are more attractive, reinvest in the business, including bolt-on acquisitions. Quarterly dividends The Board has declared a fourth interim dividend of 23 pence per share (Q4 2012: 22 pence per share) making 78 pence for the full year. Payment of dividends The equivalent interim dividend receivable by ADR holders is 74.9616 cents per ADS based on an exchange rate of £1/$1.6296.  The ex-dividend date will be 19 February, with a record date of 21 February and a payment date of 10 April 2014.

	Paid/ payable	Pence per share	£m
	------------	------------	------------
2013
First interim	11 July 2013	18	878
Second interim	3 October 2013	18	864
Third interim	9 January 2014	19	910
Fourth interim	10 April 2014	23	1,102
		------------	------------
		78	3,754
		------------	------------
2012
First interim	5 July 2012	17	846
Second interim	4 October 2012	17	830
Third interim	3 January 2013	18	870
Fourth interim	11 April 2013	22	1,068
		------------	------------
		74	3,614
		------------	------------

Share repurchases During the year, GSK repurchased 92.4 million shares at a cost of £1,504 million (2012: £2,493 million).  The company issued 44.6 million shares under employee share schemes amounting to £585 million (2012: £356 million). The weighted average number of shares for 2013 was 4,831 million, compared with 4,912 million in 2012, a reduction of 1.6%.  The weighted average number of shares for Q4 2013 was 4,798 million, compared with 4,843 million in Q4 2012.

Divisional performance

Pharmaceutical sales summary

	2013		Q4 2013
	------------------------------------		------------------------------------
	£m	CER%	£m	CER%
	------------	------------	------------	------------
Respiratory	7,516	4	1,982	7
Anti-virals	667	(6)	202	10
Central nervous system	1,483	(8)	384	(3)
Cardiovascular and urogenital	2,239	(8)	548	(2)
Metabolic	174	10	43	2
Anti-bacterials	1,239	-	309	(5)
Oncology and emesis	969	22	266	24
Dermatology	770	(8)	171	(19)
Rare diseases	495	7	130	(1)
Immuno-inflammation	161	>100	46	59
ViiV Healthcare (HIV)	1,386	-	385	15
Other	799	6	255	17
	------------	------------	------------	------------
	17,898	1	4,721	5
	------------	------------	------------	------------

Respiratory 2013 (£7,516 million; up 4%) Respiratory sales in 2013 grew 4% to £7,516 million, with the US up 7%, Europe down 3%, EMAP up 4% and Japan up 9%.  Seretide/Advair sales were up 4% to £5,274 million, largely driven by a strong US performance.  Flixotide/Flovent sales increased 2% to £796 million, and Ventolin sales grew 2% to £642 million.  Xyzal sales, almost exclusively made in Japan, grew 26% to £137 million, reflecting a strong allergy season. In the US, Respiratory sales grew 7%, with Advair up 8% to £2,769 million, compared with 6% estimated underlying growth for the year (5% volume decline more than offset by an 11% positive impact of price and mix).  Flovent sales were up 6% to £482 million with estimated underlying growth for the year up 6% (4% volume decrease offset by a 10% positive impact of price and mix).  Ventolin grew 4% to £291 million, with estimated underlying growth of 8%, driven mostly by improved price realisation in the first half of the year.  The launch of Breo Ellipta began in Q4 2013 with £5 million of sales recorded in the quarter. European Respiratory sales were down 3% reflecting increased competition in many markets.  Seretide sales were down 2% to £1,458 million, with a 2% volume decrease and no net impact of price and mix.  Serevent and Flovent sales were down 17% and 7% respectively. Respiratory sales in EMAP grew 4%, but 9% excluding China, led by Seretide, which grew 4% to £429 million (12% excluding China).  Seretide continued to deliver strong growth across many EMAP markets.  Veramyst, grew 16% to £71 million and Ventolin increased 2% to £171 million. In Japan, Respiratory sales grew 9% to £567 million, with strong growth from both Xyzal and Veramyst.  Adoair sales grew 8% to £277 million.  Relvar Ellipta was launched in December 2013, recording sales of £3 million. Q4 2013 (£1,982 million; up 7%) Respiratory sales in the quarter grew 7% to £1,982 million, with the US up 14%, Europe down 4%, EMAP up 5% and Japan up 12%.  Seretide/Advair sales increased 9% to £1,398 million, Flixotide/Flovent sales increased 4% to £209 million, and Ventolin sales grew 1% to £175 million. Xyzal sales grew 22% to £36 million and Relvar/Breo Ellipta was launched in the US and Japan. US Respiratory sales were up 14% to £975 million.  Reported growth rates for Advair, Flovent and Ventolin were impacted significantly by the benefit from re-stocking by wholesalers and retailers from the low levels seen at the end of Q3 2013 together with the positive impact of comparison with relatively weak Q4 2012 stocking patterns.  Pricing pressure in the market remains significant.  Advair sales were particularly affected by the stocking patterns up 17% to £741 million, compared with an estimated underlying growth of 1%, which represented a 6% volume decline offset by a 7% positive impact of price and mix.  Flovent sales increased 8% to £124 million.  On an estimated underlying basis, Flovent was down 6% (6% volume decline and net zero impact of price and mix).  Ventolin reported sales in the US grew 3% to £80 million, with an estimated underlying decline of 9% (3% volume decrease and a 6% negative impact of price and mix). European Respiratory sales were down 4%, partly reflecting increased competition in many markets.  Seretide sales declined 4% to £368 million, representing a 5% volume decrease, partially offset by a 1% positive impact of price and mix. Respiratory sales in EMAP grew 5% despite a 22% decline in China, primarily driven by Seretide, which was down 20%.  Excluding China, EMAP Respiratory sales grew 13%, with Seretide up 17% and Ventolin up 8%. In Japan, Respiratory sales grew 12% to £154 million, with continued growth from Adoair, up 11% to £82 million and from Xyzal, which grew 19% to £31 million. Anti-virals 2013 (£667 million; down 6%) The decrease in sales of Anti-virals reflected declines in Zeffix and Hepsera in China partially offset by tender shipments of Relenza in Japan. Q4 2013 (£202 million; up 10%) Anti-virals sales increased 10% largely as a result of tender shipments of Relenza in Japan, partly offset by lower sales of Zeffix and Hepsera in China. Central nervous system 2013 (£1,483 million; down 8%) Seroxat/Paxil sales fell 16% to £285 million, primarily due to generic competition in Japan and Europe and Requip sales fell 18% to £125 million reflecting generic competition in the US and Europe.  Lamictal sales fell 7% to £557 million, primarily as a result of generic competition to Lamictal XR in the US. In the US, generic competition to Lamictal XR, which started in Q1 2013, led to the 18% fall in sales of the Lamictal franchise to £276 million. Q4 2013 (£384 million; down 3%) Declines in Seroxat/Paxil sales of 14% to £69 million and Lamictal sales of 3% to £152 million, both primarily as a result of generic competition, led to the 3% fall in sales of the category. Cardiovascular and urogenital 2013 (£2,239 million; down 8%) Sales in the category fell 8% as a result of the impact of the conclusion of the Vesicare co-promotion agreement in Q1 2012.  Excluding Vesicare, sales declined 1%. The Avodart franchise grew 10% to £857 million with 31% growth in sales of Duodart/Jalyn.  Avodart sales grew 5% to £648 million. Lovaza fell 5% to £584 million as a result of increased competition and the decline in the non-statin dyslipidemia prescription market.  Arixtra sales fell 15% to £167 million. Q4 2013 (£548 million; down 2%) The 2% decline in the category was primarily driven by sales of Lovaza, down 5% to £140 million, as a result of increased competition and a market decline in the US and Arixtra, down 36% to £33 million.  The Avodart franchise grew 13%, with strong growth in Europe, EMAP and Japan. Metabolic 2013 (£174 million; up 10%) The increase in Metabolic product sales primarily reflected higher sales of Prolia in Europe and EMAP. Q4 2013 (£43 million; up 2%) The increase in Metabolic product sales in the quarter also reflected higher sales of Prolia in Europe and EMAP. Anti-bacterials 2013 (£1,239 million; flat) Augmentin sales grew 5% to £630 million with strong growth in EMAP, reflecting, in part, a comparison with some supply interruptions in 2012.  Zinacef sales fell 14% to £55 million. Q4 2013 (£309 million; down 5%) Augmentin sales grew 3% to £165 million as growth in EMAP offset a fall in Europe. Oncology and emesis 2013 (£969 million; up 22%) Oncology and emesis sales grew 22% to £969 million, marking the second consecutive year of double digit percentage growth for the business.  US sales were up 17% with strong performances by Votrient, Promacta and Arzerra, but also contributions from the launches of two new metastatic melanoma products Tafinlar and Mekinist.  Sales in Europe grew 28% and EMAP grew 18%.  Votrient sales grew 80% to £331 million, Promacta sales grew 46% to £186 million and Arzerra sales grew 23% to £75 million.  Tykerb/Tyverb sales fell 13% to £207 million due to increased competition.  Both Hycamtin in Europe and EMAP and Argatroban in the US continued to be adversely affected by generic competition. In the US sales growth of 17% reflects continued strong growth contributions from Votrient (up 56% to £144 million) and Promacta (up 33% to £73 million), which benefited from a new indication for thrombocytopenia associated with Hepatitis C received during Q4 2012.  Arzerra grew 18% to £46 million.  The US performance also reflects contributions totalling £21 million from Tafinlar and Mekinist, which were both launched in Q2 2013 as monotherapy treatments and achieved strong uptake in the BRAF V600 melanoma market during the first few months on the market.  In January 2014, Tafinlar and Mekinist were approved by the FDA for combination use. In Europe, sales grew 28% to £339 million, led by sales of Votrient, which increased by 91% to £130 million, as it continued to build market share in many markets.  Revolade received approval in Europe for use in thrombocytopenia associated with Hepatitis C at the end of Q3 2013 and sales in the year increased by 47% to £55 million.  Tafinlar was launched in Q3 2013 in certain markets and has achieved strong uptake in these early launch markets. EMAP sales grew 18% to £149 million led by strong growth of Votrient (up 77% to £37 million) and Promacta (up 92% to £22 million).  In the region Tykerb was down 9% to £47 million, and Hycamtin was down 36% to £7 million. Q4 2013 (£266 million; up 24%) In the quarter, Oncology sales were £266 million, up 24%.  US sales were £102 million, up 21%, Europe sales were £89 million, up 26% and EMAP sales were £46 million, up 22%. Votrient, up 48% to £90 million, and Promacta, up 42% to £52 million, continued to drive the growth in Oncology.  Tafinlar and Mekinist sales also contributed to this positive result.  Tykerb/Tyverb sales fell 18% to £49 million as a result of increased competition.  Both Hycamtin in Europe and Argatroban in the US continued to be adversely affected by generic competition. Dermatology 2013 (£770 million; down 8%) Sales declined 8% to £770 million, primarily as a result of the decline in the US, down 40% to £140 million, which continued to suffer from the impact of generic competition, particularly to Bactroban, Duac and Soriatane, together with the effect of the disposal of a number of tail brands in Q2 2013.  EMAP sales grew 6% to £397 million, reflecting strong growth in Bactroban, Dermovate and Duac particularly in Middle East/Africa and Latin America.  European sales grew 5% to £170 million. Q4 2013 (£171 million; down 19%) Sales declined 19% to £171 million, principally driven by the impact of generic competition, together with the effect of the disposal of a number of tail brands in Q2 2013 in the US, down 66% to £21 million.  European sales fell 4% to £42 million and EMAP sales fell 1% to £93 million. Rare diseases 2013 (£495 million; up 7%) Volibris, up 21% to £147 million, and Mepron, up 8% to £101 million, were the main drivers of the 7% growth in the category.  Flolan sales fell 16% to £103 million, primarily as a result of the biennial price reduction in Japan in Q2 2012 and continued generic competition in the US and Europe. Q4 2013 (£130 million; down 1%) Flolan sales fell 21% to £23 million, largely as a result of continued generic competition in the US and Europe, and Mepron sales fell 19% to £25 million.  Volibris partially offset these declines, with growth of 23% to £40 million, led by a strong performance in Japan. Immuno-inflammation 2013 (£161 million; up >100%) Benlysta turnover in the year was £146 million, with £134 million in the US.  Total in-market sales of Benlysta in the US in 2012 were £96 million. Q4 2013 (£46 million; up 59%) Benlysta sales were £37 million, up 28%.  In the US, Benlysta sales in the quarter were £33 million, up 26%. ViiV Healthcare (HIV) 2013 (£1,386 million; flat) ViiV Healthcare sales of £1,386 million were flat as sales in the US were up 5%, Europe down 3% and EMAP down 12%.  Epzicom/Kivexa sales increased 14% to £763 million and Selzentry was up 10% to £143 million.  Tivicay recorded sales of £19 million from the early stages of its launch in the US, which started in August 2013.  Tivicay was approved in Europe in January 2014 and launches are planned in several markets throughout 2014.  Growth contributions within this business were offset by declines in the mature portion of the portfolio, mainly Combivir, down 36% to £116 million. Q4 2013 (£385 million; up 15%) ViiV Healthcare sales increased 15%, with the US up 30%, including a favourable adjustment to US accruals for returns and rebates, Europe up 1%, and EMAP up 7%.  Sales growth in Epzicom/Kivexa, up 28% to £211 million, and the newly-launched Tivicay, with sales of £15 million, were partially offset by declines in the mature portfolio.

Vaccines sales

	2013		Q4 2013
	------------------------------------		------------------------------------
	£m	CER%	£m	CER%
	------------	------------	------------	------------
Total Vaccines sales	3,420	2	967	12
	------------	------------	------------	------------

2013 (£3,420 million; up 2%) Performance of the Vaccines business improved towards the end of the year, with a significant increase in tender sales in Q4.  The 2% increase in Vaccines sales was principally attributable to the growth of Infanrix/Pediarix, Fluarix/FluLaval and Boostrix, which was largely offset by the decline of Cervarix in Japan, reflecting the suspension of the recommendations for the use of HPV vaccines in Japan, together with an adverse comparison with strong Cervarix sales in 2012, which benefited from the final stages of the HPV vaccination catch-up programme in Japan.  Cervarix sales declined 37% to £172 million.  Excluding Cervarix in Japan, Vaccines sales increased by 5%. Infanrix/ Pediarix sales increased 9% to £862 million, with the growth primarily reflecting stronger tender shipments in Europe and EMAP as well as the benefit in the US of a competitor supply shortage.  Boostrix sales, which also benefited from a competitor supply issue in the US, grew 19% to £288 million. Sales of hepatitis vaccines fell 4% to £629 million, primarily reflecting lower sales in the US as a result of the return of competing vaccines to the market during the second half of 2012, together with declines in Europe and China. Synflorix sales increased 2% to £405 million, helped by strong tender sales in Middle East/Africa and Latin America. Rotarix sales grew 5% to £375 million, with strong growth in Middle East/Africa and Europe partially offset by the impact of increased competition in Japan. Fluarix/FluLaval sales increased 25% to £251 million, following the launch of the Quadrivalent formulation in the US. Q4 2013 (£967 million; up 12%) Vaccines sales grew 12% to £967 million and benefited from strong growth of Synflorix in EMAP and Fluarix/FluLaval and Boostrix in the US.  The 44% decline in sales in Japan reflected the impact on Cervarix of the suspension of the recommendation for the use of HPV vaccines. Infanrix/Pediarix sales decreased 11% to £208 million, mainly driven by a strong comparative in EMAP where sales more than doubled in Q4 2012.  Sales in the US were down 10%, primarily reflecting ordering patterns from the CDC in Q3 2013, when Infanrix/Pediarix grew 69%.  Boostrix sales grew 65% to £91 million, with strong growth in the US. Sales of hepatitis vaccines fell 4% to £152 million, principally reflecting a decline in the US. Synflorix sales increased 49% to £161 million, reflecting strong tender sales, particularly in Brazil, in the quarter. Rotarix sales were up 17% to £100 million, with growth in Europe and EMAP being partially offset by a decline in the US. The new Quadrivalent formulation benefited sales of Fluarix/FluLaval, which were up 76% at £87 million.  In the US, Fluarix/FluLaval sales more than doubled to £36 million following the launch of the Quadrivalent formulation and a favourable comparison with 2012, where the majority of the Fluarix/FluLaval shipments were made in Q3 2012.

Sales from new pharmaceutical and vaccine launches

	2013		Q4 2013
	------------------------------------		------------------------------------
	£m	CER%	£m	CER%
	------------	------------	------------	------------
Pharmaceuticals
Arzerra	75	23	19	36
Benlysta	146	>100	37	28
Duodart/Jalyn	209	31	56	27
Lamictal XR	98	(34)	29	(24)
Mekinist	10	-	7	-
Potiga/Trobalt	11	43	3	(33)
Prolia	51	96	16	89
Relvar/Breo Ellipta	8	-	8	-
Tafinlar	16	-	11	-
Tivicay	19	-	15	-
Votrient	331	80	90	48
Xgeva	7	>100	3	>100
Dermatology	8	20	4	>100
Vaccines
Synflorix	405	2	161	49
Nimenrix	12	>100	6	>100
	------------	------------	------------	------------
	1,406	33	465	50
	------------	------------	------------	------------

New products are those launched in the last five years (2009 to 2013 inclusive).  Sales of new products were £1,406 million in 2013, grew 33% in the year and represented 7% of Pharmaceuticals and Vaccines turnover.  In Q4 2013, sales of new products were £465 million, grew 50% and represented 8% of Pharmaceuticals and Vaccines turnover. Tafinlar and Mekinist, both for metastatic melanoma, were approved and launched in the US in Q2 2013.  In Q3 2013, Tivicay, for the treatment of HIV-1 patients, was approved and launched in the US and Tafinlar was granted approval and launched in Europe.  In Q4 2013, Breo Ellipta was launched in the US for COPD and Relvar Ellipta was granted approval in Europe for COPD and asthma and launched in Q1 2014.  In addition, launch activities are currently underway for Anoro Ellipta, which was approved in the US for the treatment of COPD in December 2013.

Consumer Healthcare

	2013			Q4 2013
	------------------------------------------------------------------------			------------------------------------------------------------------------
Turnover			Growth excluding non-core OTC products			Growth excluding non-core OTC products
	£m	CER%	CER%	£m	CER%	CER%
	------------	------------	------------	------------	------------	------------
Total wellness	1,935	(5)	1	469	(6)	(5)
Oral care	1,884	6	6	447	4	4
Nutrition	1,096	7	7	235	6	6
Skin health	272	5	5	67	5	5
	------------	------------	------------	------------	------------	------------
Total	5,187	2	4	1,218	-	1
	------------	------------	------------	------------	------------	------------

	2013			Q4 2013
	------------------------------------------------------------------------			------------------------------------------------------------------------
Turnover			Growth excluding non-core OTC products			Growth excluding non-core OTC products
	£m	CER%	CER%	£m	CER%	CER%
	------------	------------	------------	------------	------------	------------
USA	951	1	2	242	(2)	(2)
Europe	1,819	(1)	3	435	(4)	(3)
Rest of World	2,417	4	6	541	5	5
	------------	------------	------------	------------	------------	------------
Total	5,187	2	4	1,218	-	1
	------------	------------	------------	------------	------------	------------

2013 (£5,187 million; up 2%) Consumer Healthcare turnover grew 2% in the year.  Excluding the non-core OTC brands that were divested in H1 2012, turnover grew 4% reflecting overall growth in all three regions. Total wellness sales, excluding the non-core OTC brands that were divested in H1 2012, grew 1%.  In both the US and Europe alli reported strong growth, in large part due to being out of stock for much of 2012.  A severe cold and flu season in early 2013 helped drive growth of several respiratory brands including Coldrex, Beechams and Panadol Cold and Flu.  This growth was partly offset by a 57% reduction in sales in China of Contac, due to new shelving requirements, and Fenbid, down 31%, in advance of mandatory price reductions. Strong growth in Oral care sales was led by growth in Specialist oral health, with Sensodyne Sensitivity and Acid erosion up 15% and denture care brands up 9%. Nutrition sales grew 7% with strong growth in Rest of World markets, led by Horlicks, up 14%, and Boost in India and key expansion markets in the sub-continent.  Lucozade grew 4% and Ribena grew 3%.  Sales of Maxinutrition products declined 25%. Skin health sales grew 5%, led by Abreva in the US. Excluding the non-core OTC products divested in 2012, US sales grew 2%, led by strong contributions from Oral care brands, alli and Abreva.  This was partially offset by declines in Gastro-intestinal products, reflecting increased competitor activity, and Smoking control products impacted by supply disruptions.  In Europe, sales grew 3% helped by sales of alli and strong growth in products for Respiratory health and Pain.  Oral care sales in Europe were flat, as strong growth in Sensodyne and denture care brands was offset by a decline in Aquafresh, due in part to supply issues in Q4 2013.  Rest of World markets grew 6%, reflecting growth across most categories and markets, particularly in India, offset by a 23% reduction of sales in China, mainly due to the reduction in sales of Contac and Fenbid.  Q4 2013 (£1,218 million; flat) Consumer Healthcare turnover was flat in the quarter, but grew 1% excluding the non-core OTC brands that were divested in H1 2012.  Growth in Rest of World markets was partially offset by declines in the US and Europe. Total wellness sales declined 5%, reflecting lower sales from several brands within the category, including Breathe Right, down 21%, and Tums, down 15%, partly as a result of increased competitor activity.  Contac sales fell 24% following new shelving requirements in China and there was a 33% reduction in sales of Fenbid in China.  Smoking control products grew 3%. Oral care sales were up 4% to £447 million.  Strong growth contributions from the Sensodyne Sensitivity and Acid erosion business, up 16%, and denture care brands, up 9%, offset a decline in sales of Aquafresh of 19%, due in part to supply issues in Europe. Nutrition sales grew 6% led by strong growth of Horlicks driven by improved consumer access in India, up 13% and bolstered by geographic expansion in the region.  Sales of Boost energy drink were up 8% also reflecting a strong performance in India. Lucozade and Ribena sales grew 5% and 2%, respectively, mainly driven by a strong performance in Rest of World markets. Skin health sales grew 5%, in part reflecting some retailer stocking movements on Abreva in the US. In the US, sales declined 2%, as strong growth in Oral care products was offset by lower sales of Breathe Right, Tums and alli.  In Europe, sales, excluding the non-core OTC brands divested, fell 3%, reflecting the impact of the temporary supply issues with Aquafresh.  Growth in several cough and cold brands was also adversely affected by the phasing of shipments and comparison with a strong start to the cold and flu season in Q4 2012.  Rest of World markets grew 5%, reflecting strong growth across most categories and markets, particularly India, partially offset by a 24% reduction of sales in China, primarily due to the reduction in sales of Contac and Fenbid.

Research and development

GSK remains focused on delivering an improved return on its investment in R&D.  Sales contribution, reduced attrition and cost reduction are all important drivers of an improving internal rate of return.  R&D expenditure is not determined as a percentage of sales but instead capital is allocated using strict returns based criteria depending on the pipeline opportunities available. In 2009, we committed to publishing our estimated rate of return in R&D based on the investment made in our late-stage pipeline and our expectations regarding future long-term sales performance.  This was estimated to be 11% in 2009 and 12% in 2011.  Applying the same methodology, the estimated rate of return in 2013 has increased to 13% and we are on track to deliver on our long-term target of 14%.  This increase is driven by a higher forecast risk adjusted NPV contribution from the late-stage pipeline than two years ago, as a number of significant assets achieved key milestones, and the continued benefit of our R&D cost management programmes. As part of the process to calculate the 2013 data we also updated the 2011 IRR calculation to reflect actual sales in the 2011-2012 period and updated forecasts of the future pipeline.  This results in a 60 basis points reduction in the previously disclosed estimated IRR for this period (from 11.9% to 11.3%).  This reduction is mainly driven by lower than forecast sales for some products (primarily Tykerb and some 2010 and 2011 launch products) which are partially offset by greater than forecast sales for certain products and improvements in probability of success for a number of pipeline products which achieved key milestones since the analysis was last completed (including Anoro Ellipta, Breo Ellipta and Tivicay). The operations of Pharmaceuticals R&D are broadly split into Discovery activities (up to the completion of Phase IIa trials) and Development work (from Phase IIb onwards) each supported by specific and common infrastructure and other shared services where appropriate.  R&D expenditure for the year is analysed below.  Facilities and Central Support functions include lower credits arising from the pension and post-retirement medical obligations restructuring in 2013 than in 2012.

	2013 £m	2012 (restated) £m
	------------	------------
Discovery	742	800
Development	1,535	1,655
Facilities and central support functions	449	377
	------------	------------
	2,726	2,832
Vaccines	496	498
Consumer Healthcare	178	155
	------------	------------
Core R&D	3,400	3,485
Amortisation and impairment of intangible assets	428	483
Major restructuring costs	39	11
Acquisition accounting and other	56	-
	------------	------------
Total R&D	3,923	3,979
	------------	------------

GSK's Phase III/Registration Pharmaceuticals and Vaccines pipeline

The table below is provided as part of our quarterly update to show events and changes to the late-stage pipeline during the quarter and up to the date of this announcement.  There were several news events for late-stage pipeline assets in this quarter and these are listed in the table below.  Promacta/Revolade and Tafinlar were announced as approved in US and EU last quarter and these entries have been removed from the table. At the R&D Late-Stage Pipeline Review on 3 December 2012, the following 14 assets were listed as expecting to deliver Phase III data during 2013 and 2014: Votrient (ovarian), MAGE-A3 (melanoma & NSCLC), Tykerb (breast, head & neck and gastric cancers), darapladib (atherosclerosis - event driven), Arzerra (first line and relapsed CLL), drisapersen (DMD), dabrafenib + trametinib combination use (metastatic melanoma), fluticasone furoate (asthma), mepolizumab (severe asthma), Benlysta subcutaneous (SLE) (data now expected in 2015), vercirnon (Crohn's disease), migalastat (Fabry's disease), Herpes Zoster vaccine (data are event driven and now expected in 2015) and dolutegravir-Trii (HIV). In 2014 and 2015 we expect potential Phase III starts for the following assets: ICS/LABA/LAMA (COPD); ICS/LAMA (asthma); afuresertib (AKT inhibitor for multiple myeloma); '744 long acting integrase inhibitor (HIV); losmapimod (Acute Coronary Syndrome); '728 antisense oligonucleotide (transthyretin amyloidosis); '275 gene therapy (Wiskott-Aldrich Syndrome); '944 topoisomerase inhibitor (antibacterial); retosiban (pre-term labour); tafenoquine (malaria); PRAME ASCI (NSCLC).

Since Q3 2013, the following pipeline milestones have been achieved:
·	Announced that darapladib did not meet the primary endpoint in STABILITY study in patients with coronary heart disease;
·	Announced the return of development and commercialisation rights for migalastat to Amicus;
·	EU approval of Relvar Ellipta for asthma and COPD;
·	CHMP positive opinion for Tivicay for HIV in EU;
·	Japanese approval of Paxil for PTSD;
·	FDA approval of pandemic H5N1 vaccine;
·	EU approval of Synflorix for prevention of pneumonia caused by S. pneumoniae in children 6 weeks to 5 years old;
·	Filed dolutegravir for HIV in Japan;
·	Announced positive results from Phase III study of fluticasone furoate/vilanterol in asthma;
·	FDA granted priority review for Arzerra as first line treatment for CLL;
·	FDA approval of Anoro Ellipta for COPD;
·	EU approval of 2 dose schedule for Cervarix;
·	FDA approval of combination use of Mekinist and Tafinlar in unresectable or metastatic melanoma;
·	FDA granted Breakthrough Therapy designation for tafenoquine for Plasmodium Vivax malaria;
·	Announced the return of rights for drisapersen to Prosensa;
·	FDA granted Breakthrough Therapy designation for Tafinlar for NSCLC with BRAF mutation;
·	EU approval of Tivicay for HIV;
·	CHMP positive opinion for albiglutide for Type 2 diabetes in EU;
·	Announced headline data from Phase III COMBI-d study of the combination of Tafinlar and Mekinist in metastatic melanoma;
·	Promacta granted Breakthrough Therapy Designation by the FDA for the treatment of severe aplastic anemia.
There are 7 filings of new drugs with US/EU regulators:
·	Mekinist (trametinib, MEK) (approved in US; filed in EU);
·	trametinib + dabrafenib in combination use (approved in US; filed in EU);
·	Eperzan (albiglutide) (filed in US and EU; positive opinion from CHMP in EU);
·	Anoro Ellipta (UMEC/VI) COPD (approved in US; filed in EU);
·	umeclidinium (LAMA) monotherapy in COPD (filed in US and EU);
·	fluticasone furoate monotherapy in asthma (filed in US);
·	dolutegravir-Trii in HIV (filed in US and EU).

Biopharmaceuticals		US	EU	News update in the quarter
Arzerra (ofatumumab)	CLL (first line & relapsed)	Filed Oct 2013	Filed Oct 2013	FDA granted Priority Review for filing in first line CLL on 17 December 2013.
	NHL (FL)	Ph III	Ph III
	NHL (DLBCL)	Ph III	Ph III
Benlysta (s.c.)	Systemic lupus erythematosus	Ph III	Ph III	Data now expected in 2015.
Benlysta (i.v.)	vasculitis	Ph III	Ph III
Eperzan (albiglutide)	Type 2 diabetes	Filed Jan 2013	Filed Mar 2013	Positive CHMP opinion on 24 January 2014.
sirukumab	Rheumatoid arthritis	Ph III	Ph III
Cardiovascular & Metabolic		US	EU	News update in the quarter
darapladib	Atherosclerosis	Ph III	Ph III	Data from STABILITY study did not meet primary endpoint.
Oncology		US	EU	News update in the quarter
Votrient (pazopanib)	Ovarian	Ph III	Filed Aug 2013
Tykerb/Tyverb	Metastatic breast cancer - dual blockade	Ph III	Approved Aug 2013
	Adjuvant breast cancer	Ph III	Ph III
Mekinist (trametinib, MEK inhibitor)	Metastatic melanoma	Approved May 2013	Filed Feb 2013
trametinib + dabrafenib in combination use	Metastatic melanoma	Approved Jan 2014	Filed Feb 2013	FDA approval on 8 January 2014.  Announced headline data from Phase III COMBI-d study on 24 January 2014.
	Adjuvant melanoma	Ph III	Ph III
Respiratory		US	EU	News update in the quarter
Relvar/Breo Ellipta (FF/VI)	COPD	Approved May 2013	Approved Nov 2013	Approved in EU on 18 November 2013.
	Asthma	Ph III	Approved Nov 2013	Approved in EU on 18 November 2013. Announced positive asthma study results 6 December 2013.
Anoro Ellipta (umeclidinium bromide (UMEC) + vilanterol (VI))	COPD	Approved Dec 2013	Filed Jan 2013	FDA approval on 18 December 2013.
umeclidinium bromide (UMEC)	COPD	Filed Apr 2013	Filed Apr 2013
vilanterol (VI)	COPD	Ph III	Ph III
fluticasone furoate (FF)	Asthma	Filed Oct 2013	Ph III
mepolizumab	Severe asthma	Ph III	Ph III
Rare Diseases		US	EU	News update in the quarter
migalastat HCl	Fabry disease	Ph III	Ph III	Announced rights returned to Amicus on 20 November 2013.
drisapersen	Duchenne muscular dystrophy	Ph II	Ph III	Announced rights returned to Prosensa on 13 January 2014.
2696273 (Ex-vivo stem cell gene therapy)	Adenosine deaminase severe combined immune deficiency (ADA-SCID)		Ph II/III
Vaccines		US	EU	News update in the quarter
Nimenrix (MenACWY)	MenACWY prophylaxis	Ph II	Approved Apr 2012
MAGE-A3	Melanoma	Ph III	Ph III
	NSCLC	Ph III	Ph III
Herpes zoster	Shingles prophylaxis	Ph III	Ph III
Mosquirix (RTS,S)	Malaria prophylaxis	n/a	n/a
HIV (ViiV Healthcare)		US	EU	News update in the quarter
Tivicay (dolutegravir, S/GSK1349572)	HIV integrase inhibitor	Approved Aug 2013	Approved Jan 2014	Approved in EU on 20 January 2014.
dolutegravir-Trii	HIV integrase inhibitor + abacavir + lamivudine fixed dose combination	Filed Oct 2013	Filed Oct 2013	Filed in EU on 25 October 2013.

Definitions

Core results Core results exclude the following items from total results: amortisation and impairment of intangible assets (excluding computer software) and goodwill; major restructuring costs, including those costs following material acquisitions; legal charges (net of insurance recoveries) and expenses on the settlement of litigation and government investigations, and acquisition accounting adjustments relating to the consolidation of material acquisitions, disposals of associates, products and businesses, other operating income other than royalty income and other items, together with the tax effects of all of these items.  GSK believes this approach provides a clearer view of the underlying performance of the core business and should make the Group's results more comparable with the majority of its peers. CER growth In order to illustrate underlying performance, it is the Group's practice to discuss its results in terms of constant exchange rate (CER) growth.  This represents growth calculated as if the exchange rates used to determine the results of overseas companies in Sterling had remained unchanged from those used in the comparative period.  All commentaries are presented in terms of CER growth, unless otherwise stated. Free cash flow Free cash flow is the net cash inflow from operating activities less capital expenditure, interest and dividends paid to non-controlling interests plus proceeds from the sale of property, plant and equipment and dividends received from joint ventures and associated undertakings.  It is used by management for planning and reporting purposes and in discussions with and presentations to investment analysts and rating agencies.  Free cash flow growth is calculated on a reported basis. Adjusted free cash flow Adjusted free cash flow excludes payments made to settle legal disputes. Free cash flow conversion Free cash flow conversion is free cash flow as a percentage of earnings excluding after-tax legal charges and legal settlements.  The prior year figures quoted on page 13 have been restated following the adoption of IAS 19R. Adjusted net cash inflow from operating activities Adjusted net cash inflow from operating activities excludes payments made to settle legal disputes. Working capital conversion cycle The working capital conversion cycle is calculated as the number of days sales outstanding plus days inventory outstanding, less days purchases outstanding. Brand names and partner acknowledgements Brand names appearing in italics throughout this document are trademarks of GSK or associated companies or used under licence by the Group, with the exception of Arixtra and Fraxiparine which are trademarks of GSK in certain markets but are primarily owned by Aspen. Cautionary statement regarding forward-looking statements Under the safe harbor provisions of the US Private Securities Litigation Reform Act of 1995, the company cautions investors that any forward-looking statements or projections made by the company, including those made in this Announcement, are subject to risks and uncertainties that may cause actual results to differ materially from those projected.  Factors that may affect the Group's operations are described under 'Risk Factors' in the 'Financial review & risk section' in the company's Annual Report 2012 included as exhibit 15.2 to the company's Annual Report on Form 20-F for 2012.

Contacts

GSK - one of the world's leading research-based pharmaceutical and healthcare companies - is committed to improving the quality of human life by enabling people to do more, feel better and live longer.  For further information please visit www.gsk.com.

GSK enquiries:
UK Media enquiries:	David Mawdsley	[phone]	(London)
	Simon Steel	[phone]	(London)
	David Daley	[phone]	(London)
	Catherine Hartley	[phone]	(London)
US Media enquiries:	Stephen Rea	[phone]	(Philadelphia)
	Melinda Stubbee	[phone]	(North Carolina)
	Mary Anne Rhyne	[phone]	(North Carolina)
	Emily Beamer	[phone]	(Philadelphia)
	Jennifer Armstrong	[phone]	(Philadelphia)
Analyst/Investor enquiries:	Sally Jackson	[phone]	(London)
	Kirsty Collins (SRI & CG)	[phone]	(London)
	Tom Curry	[phone]	(Philadelphia)
	Gary Davies	[phone]	(London)
	James Dodwell	[phone]	(London)
	Jeff McLaughlin	[phone]	(Philadelphia)
	Ziba Shamsi	[phone]	(London)
	Lucy Singah	[phone]	(London)

Registered in England & Wales: No. 3888792

Registered Office: 980 Great West Road Brentford, Middlesex TW8 9GS

Financial information

Income statements

	2013 £m	2012 (restated) £m	Q4 2013 £m	Q4 2012 (restated) £m
	------------	------------	------------	------------
TURNOVER	26,505	26,431	6,906	6,802
Cost of sales	(8,585)	(7,925)	(2,526)	(2,018)
	------------	------------	------------	------------
Gross profit	17,920	18,506	4,380	4,784
Selling, general and administration	(8,480)	(8,789)	(2,200)	(2,211)
Research and development	(3,923)	(3,979)	(1,070)	(1,144)
Royalty income	387	306	98	76
Other operating income	1,124	1,256	1,233	412
	------------	------------	------------	------------
OPERATING PROFIT	7,028	7,300	2,441	1,917
Finance income	61	79	17	25
Finance expense	(767)	(808)	(176)	(224)
Profit on disposal of interest in associates and joint ventures	282	-	253	-
Share of after tax profits of associates and joint ventures	43	29	11	10
	------------	------------	------------	------------
PROFIT BEFORE TAXATION	6,647	6,600	2,546	1,728
Taxation	(1,019)	(1,922)	(41)	(905)
Tax rate %	15.3%	29.1%	1.6%	52.4%
	------------	------------	------------	------------
PROFIT AFTER TAXATION FOR THE PERIOD	5,628	4,678	2,505	823
	------------	------------	------------	------------
Profit attributable to non-controlling interests	192	179	44	(25)
Profit attributable to shareholders	5,436	4,499	2,461	848
	------------	------------	------------	------------
	5,628	4,678	2,505	823
	------------	------------	------------	------------
EARNINGS PER SHARE	112.5p	91.6p	51.3p	17.5p
	------------	------------	------------	------------
Diluted earnings per share	110.5p	90.2p	50.4p	17.3p
	------------	------------	------------	------------

Statement of comprehensive income
	2013 £m	2012 (restated) £m
	------------	------------
Profit for the year	5,628	4,678
Items that may be reclassified subsequently to income statement:
Exchange movements on overseas net assets and net investment hedges	(255)	(226)
Fair value movements on available-for-sale investments	367	77
Deferred tax on fair value movements on available-for-sale investments	(29)	(10)
Reclassification of fair value movements on available-for-sale investments	(38)	(19)
Deferred tax reversed on reclassification of available-for-sale investments	7	10
Fair value movements on cash flow hedges	(9)	(6)
Deferred tax on fair value movements on cash flow hedges	1	-
Reclassification of cash flow hedges to income statement	2	2
Share of other comprehensive income of associates and joint ventures	15	30
	------------	------------
	61	(142)
	------------	------------
Items that will not be reclassified to income statement:
Exchange movements on overseas net assets of non-controlling interests	(35)	(30)
Actuarial gains/(losses) on defined benefit plans	847	(685)
Deferred tax on actuarial movements in defined benefit plans	(286)	193
	------------	------------
	526	(522)
	------------	------------
Other comprehensive income/(expense) for the year	587	(664)
	------------	------------
Total comprehensive income for the year	6,215	4,014
	------------	------------
Total comprehensive income for the year attributable to:
Shareholders	6,058	3,865
Non-controlling interests	157	149
	------------	------------
	6,215	4,014
	------------	------------

Statement of comprehensive income
	Q4 2013 £m	Q4 2012 (restated) £m
	------------	------------
Profit for the period	2,505	823
Items that may be reclassified subsequently to income statement:
Exchange movements on overseas net assets and net investment hedges	(164)	(50)
Fair value movements on available-for-sale investments	(78)	(43)
Deferred tax on fair value movements on available-for-sale investments	(16)	6
Reclassification of fair value movements on available-for-sale investments	(17)	(7)
Deferred tax reversed on reclassification of available-for-sale investments	4	(4)
Fair value movements on cash flow hedges	(3)	(5)
Deferred tax on fair value movements on cash flow hedges	-	1
Reclassification of cash flow hedges to income statement	-	1
Share of other comprehensive expense of associates and joint ventures	(21)	-
	------------	------------
	(295)	(101)
	------------	------------
Items that will not be reclassified to income statement:
Exchange movements on overseas net assets of non-controlling interests	(7)	(14)
Actuarial gains on defined benefit plans	376	288
Deferred tax on actuarial movements in defined benefit plans	(123)	(57)
	------------	------------
	246	217
	------------	------------
Other comprehensive (expense)/income for the period	(49)	116
	------------	------------
Total comprehensive income for the period	2,456	939
	------------	------------
Total comprehensive income for the period attributable to:
Shareholders	2,419	978
Non-controlling interests	37	(39)
	------------	------------
	2,456	939
	------------	------------

Pharmaceuticals and Vaccines turnover

Year ended 31 December 2013

	Total		USA		Europe		EMAP		Rest of World
	---------------------------		---------------------------		--------------------------		-----------------------------		---------------------------
	£m	CER%	£m	CER%	£m	CER%	£m	CER%	£m	CER%
	----------	----------	----------	----------	----------	----------	----------	----------	----------	----------
Respiratory	7,516	4	3,655	7	1,907	(3)	877	4	1,077	6
Avamys/Veramyst	249	5	42	(29)	69	8	71	16	67	23
Flixonase/Flonase	110	(14)	7	(50)	31	(6)	49	(14)	23	(7)
Flixotide/Flovent	796	2	482	6	117	(7)	58	7	139	(3)
Seretide/Advair	5,274	4	2,769	8	1,458	(2)	429	4	618	6
Serevent	129	(10)	51	(2)	55	(17)	4	33	19	(15)
Ventolin	642	2	291	4	127	(2)	171	2	53	(4)
Xyzal	137	26	-	-	-	-	18	6	119	28
Zyrtec	76	4	-	-	-	-	41	17	35	(7)
Other*	103	4	13	100	50	(9)	36	-	4	>100
Anti-virals	667	(6)	57	(2)	66	(14)	293	(20)	251	14
Hepsera	96	(21)	-	-	-	-	70	(28)	26	-
Valtrex	224	(2)	45	26	29	(15)	40	11	110	(10)
Zovirax	81	(4)	1	(67)	19	(10)	35	3	26	(3)
Zeffix	182	(26)	13	(13)	12	(25)	140	(28)	17	(17)
Other*	84	>100	(2)	<(100)	6	25	8	60	72	>100
Central nervous system	1,483	(8)	440	(15)	355	(11)	341	7	347	(8)
Imigran/Imitrex	188	1	80	11	63	(7)	7	-	38	(5)
Lamictal	557	(7)	276	(18)	110	(4)	78	8	93	21
Requip	125	(18)	7	(63)	52	(33)	14	-	52	15
Seroxat/Paxil	285	(16)	-	-	53	(11)	79	(4)	153	(23)
Wellbutrin	97	14	16	33	51	11	30	7	-	-
Other*	231	(5)	61	(21)	26	(20)	133	14	11	(38)
Cardiovascular and urogenital	2,239	(8)	1,244	(16)	533	2	281	(2)	181	18
Arixtra	167	(15)	50	(26)	84	(12)	28	-	5	(13)
Avodart	857	10	312	(3)	273	15	104	27	168	20
Coreg	131	(2)	130	(2)	-	-	-	-	1	-
Fraxiparine	221	(7)	-	-	138	(8)	83	(6)	-	-
Lovaza	584	(5)	581	(5)	-	-	-	-	3	-
Other*	279	(42)	171	(51)	38	(8)	66	(26)	4	-
Metabolic	174	10	4	>100	42	41	68	9	60	(20)
Other*	174	10	4	>100	42	41	68	9	60	(20)
Anti-bacterials	1,239	-	27	30	393	(6)	750	5	69	(15)
Augmentin	630	5	1	-	203	(3)	393	11	33	(5)
Other*	609	(4)	26	32	190	(9)	357	(1)	36	(22)
Oncology and emesis	969	22	380	17	339	28	149	18	101	27
Arzerra	75	23	46	18	27	29	-	-	2	100
Promacta	186	46	73	33	55	47	22	92	36	50
Tyverb/Tykerb	207	(13)	55	(21)	82	(9)	47	(9)	23	(10)
Votrient	331	80	144	56	130	91	37	77	20	>100
Other*	170	(9)	62	(10)	45	(9)	43	2	20	(26)
Dermatology	770	(8)	140	(40)	170	5	397	6	63	(9)
Bactroban	98	(19)	29	(45)	24	(12)	38	5	7	-
Duac	72	(17)	15	(61)	29	17	16	38	12	(8)
Other*	600	(4)	96	(32)	117	7	343	5	44	(11)
Rare diseases	495	7	113	(4)	129	1	48	2	205	17
Volibris	147	21	-	-	82	10	11	22	54	40
Flolan	103	(16)	25	(24)	18	(26)	-	-	60	(9)
Other*	245	12	88	4	29	-	37	(3)	91	30
Immuno-inflammation	161	>100	148	>100	8	100	1	-	4	>100
Benlysta	146	>100	134	>100	8	100	1	-	3	100
Other*	15	-	14	-	-	-	-	-	1	-
Other pharmaceuticals*	799	6	6	(74)	175	(7)	369	(3)	249	48
Vaccines	3,420	2	978	17	1,049	3	1,124	1	269	(31)
Boostrix	288	19	183	23	65	19	20	25	20	(9)
Cervarix	172	(37)	6	-	61	11	92	23	13	(90)
Fluarix, FluLaval	251	25	146	65	35	(21)	43	(2)	27	8
Hepatitis	629	(4)	263	(3)	198	(3)	123	(2)	45	(15)
Infanrix, Pediarix	862	9	271	23	398	2	132	11	61	3
Rotarix	375	5	108	7	59	49	164	3	44	(21)
Synflorix	405	2	-	-	48	2	350	1	7	17
Other*	438	(4)	1	(100)	185	2	200	(14)	52	27
	----------	----------	----------	----------	----------	----------	----------	----------	----------	----------
	19,932	1	7,192	1	5,166	-	4,698	1	2,876	3
ViiV Healthcare (HIV)	1,386	-	----------	----------	----------	----------	----------	----------	----------	----------
	----------	----------
	21,318	1
	----------	----------

Pharmaceuticals and Vaccines turnover

Three months ended 31 December 2013

	Total		USA		Europe		EMAP		Rest of World
	---------------------------		---------------------------		--------------------------		-----------------------------		---------------------------
	£m	CER%	£m	CER%	£m	CER%	£m	CER%	£m	CER%
	----------	----------	----------	----------	----------	----------	----------	----------	----------	----------
Respiratory	1,982	7	975	14	483	(4)	238	5	286	8
Avamys/Veramyst	54	(5)	6	(56)	16	23	18	6	14	15
Flixonase/Flonase	25	(19)	4	33	7	(25)	10	(31)	4	-
Flixotide/Flovent	209	4	124	8	30	(9)	17	13	38	-
Seretide/Advair	1,398	9	741	17	368	(4)	119	6	170	8
Serevent	31	(9)	13	(8)	14	(13)	1	-	3	-
Ventolin	175	1	80	3	33	(6)	47	6	15	(6)
Xyzal	36	22	-	-	-	-	5	67	31	18
Zyrtec	20	-	-	-	-	-	11	-	9	-
Other*	34	42	7	>100	15	(7)	10	22	2	>100
Anti-virals	202	10	17	(45)	16	14	71	(23)	98	86
Hepsera	23	(27)	-	-	-	-	15	(36)	8	-
Valtrex	59	(7)	15	(30)	7	17	10	22	27	(6)
Zovirax	20	-	-	-	4	25	10	-	6	(13)
Zeffix	43	(30)	3	(40)	3	-	33	(31)	4	(29)
Other*	57	>100	(1)	(100)	2	-	3	-	53	>100
Central nervous system	384	(3)	116	(9)	86	(10)	90	4	92	2
Imigran/Imitrex	46	-	18	6	15	(6)	2	-	11	-
Lamictal	152	(3)	77	(15)	28	-	20	16	27	22
Requip	29	(3)	1	-	11	(29)	3	-	14	29
Seroxat/Paxil	69	(14)	-	-	12	(27)	19	(9)	38	(15)
Wellbutrin	26	23	6	100	14	18	8	14	(2)	(100)
Other*	62	-	14	(13)	6	(14)	38	5	4	33
Cardiovascular and urogenital	548	(2)	296	(7)	135	3	67	(6)	50	20
Arixtra	33	(36)	7	(63)	20	(14)	6	(33)	-	-
Avodart	226	13	80	1	72	13	27	43	47	19
Coreg	29	(3)	29	-	-	-	-	-	-	-
Fraxiparine	55	(5)	-	-	34	-	21	(16)	-	-
Lovaza	140	(5)	139	(5)	-	-	-	-	1	-
Other*	65	(13)	41	(7)	9	(11)	13	(32)	2	67
Metabolic	43	2	2	-	12	33	16	13	13	(20)
Other*	43	2	2	-	12	33	16	13	13	(20)
Anti-bacterials	309	(5)	6	-	102	(8)	184	(2)	17	(16)
Augmentin	165	3	1	-	53	(4)	101	6	10	-
Other*	144	(12)	5	(20)	49	(12)	83	(10)	7	(29)
Oncology and emesis	266	24	102	21	89	26	46	22	29	29
Arzerra	19	36	13	30	5	25	-	-	1	-
Promacta	52	42	19	27	16	45	6	75	11	50
Tyverb/Tykerb	49	(18)	11	(35)	19	(10)	14	-	5	(33)
Votrient	90	48	39	34	35	55	11	33	5	>100
Other*	56	28	20	47	14	20	15	23	7	-
Dermatology	171	(19)	21	(66)	42	(4)	93	(1)	15	(5)
Bactroban	23	(25)	7	(50)	6	-	7	(10)	3	-
Duac	19	(10)	4	(33)	8	17	4	25	3	(40)
Other*	129	(20)	10	(76)	28	(10)	82	(2)	9	18
Rare diseases	130	(1)	27	(24)	34	3	14	(7)	55	14
Volibris	40	23	-	-	21	17	3	50	16	27
Flolan	23	(21)	6	(33)	4	(40)	-	-	13	(10)
Other*	67	(3)	21	(21)	9	-	11	(15)	26	25
Immuno-inflammation	46	59	41	57	2	50	-	-	3	-
Benlysta	37	28	33	26	2	50	-	-	2	-
Other*	9	-	8	-	-	-	-	-	1	-
Other pharmaceuticals*	255	17	4	(75)	54	(16)	98	(2)	99	>100
Vaccines	967	12	243	23	275	-	389	22	60	(16)
Boostrix	91	65	65	97	15	7	7	40	4	33
Cervarix	45	2	1	-	19	38	25	18	-	-
Fluarix, FluLaval	87	76	36	>100	21	(23)	22	>100	8	50
Hepatitis	152	(4)	55	(7)	52	2	34	12	11	(41)
Infanrix, Pediarix	208	(11)	61	(10)	101	(4)	32	(33)	14	-
Rotarix	100	17	24	(4)	15	50	46	31	15	-
Synflorix	161	49	-	-	12	(8)	147	58	2	-
Other*	123	(3)	1	<(100)	40	-	76	1	6	(15)
	----------	----------	----------	----------	----------	----------	----------	----------	----------	----------
	5,303	5	1,850	5	1,330	(2)	1,306	5	817	18
ViiV Healthcare (HIV)	385	15	----------	----------	----------	----------	----------	----------	----------	----------
	----------	----------
	5,688	6
	----------	----------

ViiV Healthcare turnover

Year ended 31 December 2013

	Total		USA		Europe		EMAP		Rest of World
	---------------------------		---------------------------		--------------------------		-----------------------------		----------------------------
	£m	CER%	£m	CER%	£m	CER%	£m	CER%	£m	CER%
	----------	----------	----------	----------	----------	----------	----------	----------	----------	----------
Combivir	116	(36)	35	46	39	(41)	35	(56)	7	(36)
Epivir	43	(10)	10	25	16	(29)	11	(5)	6	(2)
Epzicom/Kivexa	763	14	269	9	328	11	78	38	88	22
Selzentry	143	10	58	1	63	8	6	67	16	47
Trizivir	97	(10)	58	(6)	32	(17)	4	(26)	3	1
Other*	224	(10)	122	(5)	48	(22)	37	(7)	17	(9)
	----------	----------	----------	----------	----------	----------	----------	----------	----------	----------
	1,386	-	552	5	526	(3)	171	(12)	137	12
	----------	----------	----------	----------	----------	----------	----------	----------	----------	----------

Three months ended 31 December 2013

	Total		USA		Europe		EMAP		Rest of World
	---------------------------		---------------------------		--------------------------		-----------------------------		----------------------------
	£m	CER%	£m	CER%	£m	CER%	£m	CER%	£m	CER%
	----------	----------	----------	----------	----------	----------	----------	----------	----------	----------
Combivir	31	(26)	11	27	7	(52)	11	(32)	2	(28)
Epivir	9	-	3	46	4	(27)	2	2	-	-
Epzicom/Kivexa	211	28	80	35	88	15	18	70	25	31
Selzentry	37	(3)	14	(16)	17	11	1	(4)	5	4
Trizivir	26	-	16	2	7	(11)	1	>100	2	(11)
Other*	71	29	47	67	12	(12)	8	(8)	4	2
	----------	----------	----------	----------	----------	----------	----------	----------	----------	----------
	385	15	171	30	135	1	41	7	38	16
	----------	----------	----------	----------	----------	----------	----------	----------	----------	----------

*	All "Other" Pharmaceuticals and Vaccines product sales totalled £3,971 million and decreased 4% in the year and totalled £1,115 million and increased 7% in Q4 2013.  Other Pharmaceuticals turnover includes milestone income received from Theravance of £78 million in 2013 and £52 million in Q4 2013.

Balance sheet

	31 December 2013 £m	31 December 2012 (restated) £m
	------------	------------
ASSETS
Non-current assets
Property, plant and equipment	8,872	8,776
Goodwill	4,205	4,359
Other intangible assets	9,283	10,161
Investments in associates and joint ventures	323	579
Other investments	1,202	787
Deferred tax assets	2,084	2,391
Derivative financial instruments	1	54
Other non-current assets	889	682
	------------	------------
Total non-current assets	26,859	27,789
	------------	------------
Current assets
Inventories	3,900	3,969
Current tax recoverable	129	103
Trade and other receivables	5,442	5,242
Derivative financial instruments	155	49
Liquid investments	66	81
Cash and cash equivalents	5,534	4,184
Assets held for sale	1	64
	------------	------------
Total current assets	15,227	13,692
	------------	------------
TOTAL ASSETS	42,086	41,481
	------------	------------
LIABILITIES
Current liabilities
Short-term borrowings	(2,789)	(3,631)
Trade and other payables	(8,317)	(8,054)
Derivative financial instruments	(127)	(63)
Current tax payable	(1,452)	(1,374)
Short-term provisions	(992)	(693)
	------------	------------
Total current liabilities	(13,677)	(13,815)
	------------	------------
Non-current liabilities
Long term borrowings	(15,456)	(14,671)
Deferred tax liabilities	(693)	(1,004)
Pensions and other post-employment benefits	(2,189)	(3,121)
Other provisions	(552)	(699)
Derivative financial instruments	(3)	(2)
Other non-current liabilities	(1,704)	(1,432)
	------------	------------
Total non-current liabilities	(20,597)	(20,929)
	------------	------------
TOTAL LIABILITIES	(34,274)	(34,744)
	------------	------------
NET ASSETS	7,812	6,737
	------------	------------
EQUITY
Share capital	1,336	1,349
Share premium account	2,595	2,022
Retained earnings	913	642
Other reserves	2,153	1,787
	------------	------------
Shareholders' equity	6,997	5,800
Non-controlling interests	815	937
	------------	------------
TOTAL EQUITY	7,812	6,737
	------------	------------

Statement of changes in equity

	Share capital £m	Share premium £m	Retained earnings £m	Other reserves £m	Share- holder's equity £m	Non- controlling interests £m	Total equity £m
	------------	------------	------------	------------	------------	------------	------------
At 1 January 2013 as previously reported	1,349	2,022	652	1,787	5,810	937	6,747
Prior year adjustment - IAS 19R			(10)		(10)		(10)
	------------	------------	------------	------------	------------	------------	------------
At 1 January 2013 as restated	1,349	2,022	642	1,787	5,800	937	6,737
Profit for the period			5,436		5,436	192	5,628
Other comprehensive      income/(expense) for the period			316	306	622	(35)	587
			------------	------------	------------	------------	------------
Total comprehensive income    for the period			5,752	306	6,058	157	6,215
			------------	------------	------------	------------	------------
Distributions to non-controlling interests						(238)	(238)
Dividends to shareholders			(3,680)		(3,680)		(3,680)
Changes in non-controlling interests			(584)		(584)	(41)	(625)
Shares issued	12	573			585		585
Ordinary shares purchased and    cancelled or held as Treasury shares	(25)		(1,504)	25	(1,504)		(1,504)
Shares acquired by ESOP Trusts				(45)	(45)		(45)
Write-down on shares held by ESOP    Trusts			(80)	80	-		-
Share-based incentive plans			294		294		294
Tax on share-based incentive plans			73		73		73
	------------	------------	------------	------------	------------	------------	------------
At 31 December 2013	1,336	2,595	913	2,153	6,997	815	7,812
	------------	------------	------------	------------	------------	------------	------------

At 1 January 2012 as previously reported	1,387	1,673	3,370	1,602	8,032	795	8,827
Prior year adjustment - IAS 19R			(13)		(13)		(13)
	------------	------------	------------	------------	------------	------------	------------
At 1 January 2012 as restated	1,387	1,673	3,357	1,602	8,019	795	8,814
Profit for the period			4,499		4,499	179	4,678
Other comprehensive      (expense)/income for the period			(665)	31	(634)	(30)	(664)
			------------	------------	------------	------------	------------
Total comprehensive income    for the period			3,834	31	3,865	149	4,014
			------------	------------	------------	------------	------------
Distributions to non-controlling interests						(171)	(171)
Dividends to shareholders			(3,814)		(3,814)		(3,814)
Changes in non-controlling interests			(382)		(382)	164	(218)
Forward contract relating to non-controlling interest				8	8	-	8
Shares issued	7	349			356		356
Ordinary shares purchased and    cancelled or held as Treasury shares	(45)		(2,493)	45	(2,493)		(2,493)
Consideration received for shares    transferred by ESOP Trusts				58	58		58
Shares acquired by ESOP Trusts				(37)	(37)		(37)
Write-down on shares held by ESOP    Trusts			(80)	80	-		-
Share-based incentive plans			211		211		211
Tax on share-based incentive plans			9		9		9
	------------	------------	------------	------------	------------	------------	------------
At 31 December 2012	1,349	2,022	642	1,787	5,800	937	6,737
	------------	------------	------------	------------	------------	------------	------------

Cash flow statement

Year ended 31 December 2013

			2013 £m	2012 (restated) £m
			------------	------------
Profit after tax			5,628	4,678
Tax on profits			1,019	1,922
Share of after tax profits of associates and joint ventures			(43)	(29)
Profit on disposal of interest in associates			(282)	-
Net finance expense			706	729
Depreciation and other adjusting items			1,415	1,085
Decrease in working capital			46	397
Increase/(decrease) in other net liabilities			10	(2,734)
			------------	------------
Cash generated from operations			8,499	6,048
Taxation paid			(1,277)	(1,673)
			------------	------------
Net cash inflow from operating activities			7,222	4,375
			------------	------------
Cash flow from investing activities
Purchase of property, plant and equipment			(1,188)	(1,051)
Proceeds from sale of property, plant and equipment			46	68
Purchase of intangible assets			(513)	(469)
Proceeds from sale of intangible assets			136	1,056
Purchase of equity investments			(133)	(229)
Proceeds from sale of equity investments			59	28
Purchase of businesses, net of cash acquired			(247)	(2,235)
Disposal of businesses			1,851	-
Investment in associates and joint ventures			(8)	(99)
Proceeds from disposal of associates and joint ventures			429	-
Decrease in liquid investments			15	224
Interest received			59	30
Dividends from associates and joint ventures			18	46
			------------	------------
Net cash inflow/(outflow) from investing activities			524	(2,631)
			------------	------------
Cash flow from financing activities
Proceeds from own shares for employee share options			-	58
Issue of share capital			585	356
Shares acquired by ESOP Trusts			(45)	(37)
Shares purchased and cancelled or held as Treasury shares			(1,504)	(2,493)
Purchase of non-controlling interests			(588)	(14)
Increase in long-term loans			1,913	4,430
Repayment of short-term loans			(1,872)	(2,559)
Increase in short-term loans			-	1,743
Net repayment of obligations under finance leases			(31)	(35)
Interest paid			(749)	(779)
Dividends paid to shareholders			(3,680)	(3,814)
Distributions to non-controlling interests			(238)	(171)
Other financing items			(64)	(36)
			------------	------------
Net cash outflow from financing activities			(6,273)	(3,351)
			------------	------------
Increase/(decrease) in cash and bank overdrafts in the year			1,473	(1,607)
			------------	------------
Cash and bank overdrafts at beginning of the year			3,906	5,605
Exchange adjustments			(148)	(92)
Increase/(decrease) in cash and bank overdrafts			1,473	(1,607)
			------------	------------
Cash and bank overdrafts at end of the year			5,231	3,906
			------------	------------
Cash and bank overdrafts at end of the year comprise:
	Cash and cash equivalents		5,534	4,184
	Overdrafts		(303)	(278)
			------------	------------
			5,231	3,906
			------------	------------

Segment information

Operating segments are reported based on the financial information provided to the Chief Executive Officer and the responsibilities of the Corporate Executive Team (CET).  Individual members of the CET are responsible for each geographic segment of the Pharmaceuticals and Vaccines business, ViiV Healthcare and the Consumer Healthcare business as a whole, respectively.  Several minor product reclassifications between the Pharmaceuticals and Consumer Healthcare segments have been made with effect from 1 January 2013.  Comparative information has been restated accordingly. R&D investment is essential for the sustainability of the pharmaceutical businesses.  However, for segment reporting, the US, Europe, EMAP and Japan Pharmaceuticals and Vaccines operating profits exclude allocations of globally funded R&D as well as central costs, principally corporate functions and unallocated manufacturing costs.  The Group's management reporting process allocates intra-Group profit on a product sale to the market in which that sale is recorded, and the profit analyses below have been presented on that basis. Other trading and unallocated pharmaceuticals and vaccines includes Canada, Puerto Rico, Australasia, central vaccine tender sales and contract manufacturing sales, together with costs such as vaccines R&D, central dermatology costs and central manufacturing costs not attributed to other segments. The Pharmaceuticals R&D segment is the responsibility of the Chairman, Research & Development and is reported as a separate segment. Corporate and other unallocated costs and disposal profits include corporate functions, costs for legal matters, fair value movements on financial instruments and investments and profits on global asset disposals.

Turnover by segment
	2013 £m	2012 (restated) £m	Growth CER%
	------------	------------	------------
USA	7,192	7,000	1
Europe	5,166	5,001	-
EMAP	4,698	4,721	1
Japan	1,657	1,969	1
ViiV Healthcare	1,386	1,374	-
Other trading and unallocated pharmaceuticals and vaccines	1,219	1,196	5
	------------	------------	------------
Pharmaceuticals and Vaccines	21,318	21,261	1
Consumer Healthcare	5,187	5,170	2
	------------	------------	------------
	26,505	26,431	1
	------------	------------	------------

Operating profit by segment
	2013 £m	2012 (restated) £m	Growth CER%
	------------	------------	------------
USA	4,993	4,786	3
Europe	2,829	2,629	3
EMAP	1,468	1,560	(3)
Japan	978	1,179	4
ViiV Healthcare	885	849	3
Pharmaceuticals R&D	(2,823)	(2,778)	1
Other trading and unallocated pharmaceuticals and vaccines	(601)	(404)	31
	------------	------------	------------
Pharmaceuticals and Vaccines	7,729	7,821	1
Consumer Healthcare	913	908	3
	------------	------------	------------
Segment profit	8,642	8,729	2
Corporate and other unallocated costs and disposal profits	(627)	(491)	30
	------------	------------	------------
Core operating profit	8,015	8,238	-
Non-core items	(987)	(938)
	------------	------------	------------
Total operating profit	7,028	7,300	(1)
Finance income	61	79
Finance costs	(767)	(808)
Profit on disposal of interest in associates and joint ventures	282	-
Share of after tax profits of associates and joint ventures	43	29
	------------	------------	------------
Profit before taxation	6,647	6,600	4
	------------	------------	------------

Turnover by segment
	Q4 2013 £m	Q4 2012 (restated) £m	Growth CER%
	------------	------------	------------
USA	1,850	1,766	5
Europe	1,330	1,311	(2)
EMAP	1,306	1,308	5
Japan	467	496	17
ViiV Healthcare	385	338	15
Other trading and unallocated pharmaceuticals and vaccines	350	315	19
	------------	------------	------------
Pharmaceuticals and Vaccines	5,688	5,534	6
Consumer Healthcare	1,218	1,268	-
	------------	------------	------------
	6,906	6,802	5
	------------	------------	------------

Operating profit by segment
	Q4 2013 £m	Q4 2012 (restated) £m	Growth CER%
	------------	------------	------------
USA	1,285	1,209	7
Europe	697	691	(2)
EMAP	473	481	6
Japan	299	302	27
ViiV Healthcare	223	180	26
Pharmaceuticals R&D	(735)	(710)	5
Other trading and unallocated pharmaceuticals and vaccines	(159)	(174)	(33)
	------------	------------	------------
Pharmaceuticals and Vaccines	2,083	1,979	13
Consumer Healthcare	225	227	5
	------------	------------	------------
Segment profit	2,308	2,206	12
Corporate and other unallocated costs and disposal profits	(220)	58	>100
	------------	------------	------------
Core operating profit	2,088	2,264	(1)
Non-core items	353	(347)
	------------	------------	------------
Total operating profit	2,441	1,917	36
Finance income	17	25
Finance costs	(176)	(224)
Profit on disposal of associates and joint ventures	253	-
Share of after tax profits of associates and joint ventures	11	10
	------------	------------	------------
Profit before taxation	2,546	1,728	57
	------------	------------	------------

Legal matters The Group is involved in significant legal and administrative proceedings, principally product liability, intellectual property, tax, anti-trust and governmental investigations as well as related private litigation, which are more fully described in the 'Legal Proceedings' note in the Annual Report 2012, as updated by the Legal matters section of the Results Announcements for Q1, Q2 and Q3 2013.  At 31 December 2013, the Group's aggregate provision for legal and other disputes (not including tax matters described under 'Taxation' below) was £0.6 billion.  The Group may become involved in significant legal proceedings in respect of which it is not possible to make a reliable estimate of the expected financial effect, if any, that could result from ultimate resolution of the proceedings.  In these cases, the Group would provide appropriate disclosures about such cases, but no provision would be made. The ultimate liability for legal claims may vary from the amounts provided and is dependent upon the outcome of litigation proceedings, investigations and possible settlement negotiations.  The Group's position could change over time, and, therefore, there can be no assurance that any losses that result from the outcome of any legal proceedings will not exceed by a material amount the amount of the provisions reported in the Group's financial accounts.  Significant developments since the quarter ending 30 September 2013 are as follows: The People's Republic of China, acting through various government agencies, continues its investigation into alleged crimes and violations of law by GSK China's operations.  The Group takes these allegations seriously and is continuing to cooperate fully with the Chinese authorities in this investigation.  The Group has informed the US Department of Justice, the US Securities and Exchange Commission and the UK Serious Fraud Office regarding the investigation.  It is not possible at this time to make a reliable estimate of the financial effect, if any, that could result from these matters. Teva Pharmaceuticals USA, Inc. ('Teva') had filed an ANDA with a Paragraph IV certification for Epzicom (the combination of lamivudine and abacavir) alleging that two patents covering the product are invalid, unenforceable or not infringed.  Lupin Ltd ('Lupin') later filed an ANDA containing a Paragraph IV certification for Trizivir (the triple combination of lamivudine, AZT and abacavir) alleging that three patents covering Trizivir are either invalid, unenforceable or not infringed.  ViiV Healthcare, the Group's affiliate, filed separate suits against Teva and Lupin in the United States District Court for the District of Delaware.  The District Court consolidated the cases, as both involve the same US patent covering the combination of lamivudine and abacavir.  On 17 December 2013, the District Court upheld the validity of the US patent with an expiry date in March 2016 which covers the combination of lamivudine and abacavir (Epzicom) and the triple combination of lamivudine, abacavir and zidovudine (Trizivir).  As part of the decision, the judge ruled that the Lupin generic version of Trizivir did not infringe the patent.  Before trial, Teva stipulated that its generic version of Epzicom would infringe the patent.  ViiV Healthcare intends to appeal the ruling that the Lupin generic version of Trizivir does not infringe the patent.  There are no other challengers to the patent for Epzicom or Trizivir at this time. Developments with respect to tax matters are described in 'Taxation' below.

Taxation Tax on core profit amounted to £1,695 million and represented an effective tax rate of 23.0% (2012: 24.4%).  The charge for taxation on total profits amounted to £1,019 million and represented an effective tax rate of 15.3% (2012: 29.1%).  The Group's balance sheet at 31 December 2013 included a tax payable liability of £1,452 million and a tax recoverable asset of £129 million. Transfer pricing and other issues are as previously described in the 'Taxation' note to the Financial Statements included in the Annual Report 2012.  There have been no material changes to tax matters since the publication of the Annual Report. GSK continues to believe that it has made adequate provision for the liabilities likely to arise from periods which are open and not yet agreed by tax authorities.  The ultimate liability for such matters may vary from the amounts provided and is dependent upon the outcome of agreements with relevant tax authorities.

Additional information

Accounting policies and basis of preparation

This unaudited Results Announcement contains condensed financial information for the year and three months ended 31 December 2013, and should be read in conjunction with the Annual Report 2012, which was prepared in accordance with International Financial Reporting Standards as adopted by the European Union.  This Results Announcement has been prepared applying consistent accounting policies to those applied by the Group in the Annual Report 2012, except that IAS 19 (Revised) 'Employee benefits' has been applied from 1 January 2013 (see page 10).  Comparative information has been restated accordingly.  In addition, IFRS 10 'Consolidated financial statements', IFRS 11 'Joint arrangements', IFRS 12 'Disclosures of interests in other entities', IFRS 13 'Fair value measurement' and amendments to IAS 1 'Presentation of financial statements', IAS 28 'Investments in associates and joint ventures' and IFRS 7 'Financial instruments: Disclosures' have been implemented from 1 January 2013.  These revisions have not had a material impact on the results or financial position of the Group. This Results Announcement does not constitute statutory accounts of the Group within the meaning of sections 434(3) and 435(3) of the Companies Act 2006.  The full Group accounts for 2012 were published in the Annual Report 2012, which has been delivered to the Registrar of Companies and on which the report of the independent auditors was unqualified and did not contain a statement under section 498 of the Companies Act 2006.

Exchange rates

GSK operates in many countries, and earns revenues and incurs costs in many currencies.  The results of the Group, as reported in Sterling, are affected by movements in exchange rates between Sterling and other currencies.  Average exchange rates, as modified by specific transaction rates for large transactions, prevailing during the period, are used to translate the results and cash flows of overseas subsidiaries, associates and joint ventures into Sterling.  Period-end rates are used to translate the net assets of those entities.  The currencies which most influenced these translations and the relevant exchange rates were:

			2013	2012	Q4 2013	Q4 2012
			------------	------------	------------	------------
Average rates:
		US$/£	1.57	1.59	1.63	1.62
		Euro/£	1.18	1.23	1.18	1.23
		Yen/£	153	127	165	133
Period end rates:
		US$/£	1.66	1.63	1.66	1.63
		Euro/£	1.20	1.23	1.20	1.23
		Yen/£	174	141	174	141

During 2013, average Sterling exchange rates were weaker against the US Dollar and the Euro but stronger against the Yen compared with the same period in 2012.  During the three months ended 31 December 2013 average Sterling exchange rates were weaker against the Euro but stronger against the US Dollar and the Yen compared with the same period in 2012. Year-end Sterling exchange rates were weaker against the Euro but stronger against the US dollar and the Yen compared with 2012 year-end rates.

Weighted average number of shares
	2013 millions	2012 millions
	------------	------------
Weighted average number of shares - basic	4,831	4,912
Dilutive effect of share options and share awards	88	77
	------------	------------
Weighted average number of shares - diluted	4,919	4,989
	------------	------------

	Q4 2013 millions	Q4 2012 millions
	------------	------------
Weighted average number of shares - basic	4,798	4,843
Dilutive effect of share options and share awards	83	70
	------------	------------
Weighted average number of shares - diluted	4,881	4,913
	------------	------------

At 31 December 2013, 4,791 million shares were in free issue (excluding Treasury shares and shares held by the ESOP Trusts).  This compares with 4,827 million shares at 31 December 2012.

Net assets

The book value of net assets increased by £1,075 million from £6,737 million at 31 December 2012 to £7,812 million at 31 December 2013.  This primarily reflects a decrease in the pension deficit of £699 million, a reduction in the post-retirement provision of £439 million and retained profits in the year exceeding shares repurchased, partly offset by the liability of £635 million arising from the open offer to purchase shares held by the non-controlling interest in GlaxoSmithKline Pharmaceuticals Limited. The carrying value of investments in associates and joint ventures at 31 December 2013 was £323 million, with a market value of £1,010 million.  Assets held for sale amounted to £1 million at 31 December 2013 (31 December 2012: £64 million). At 31 December 2013, the net deficit on the Group's pension plans was £613 million compared with £1,312 million at 31 December 2012.  The decrease in the net deficit primarily arose from an increase in UK asset values together with an increase in the rate used to discount UK pension liabilities from 4.4% to 4.5%, and US pension liabilities from 3.8% to 4.6%.  In addition, special contributions of £93 million were made to the UK pension plans in the year. At 31 December 2013, the post-retirement provision was £1,246 million compared with £1,685 million at 31 December 2012.  The decrease in the provision included a £279 million adjustment arising from a one-off restructuring of post-retirement medical obligations during the year. At 31 December 2013, the ESOP Trusts held 64 million GSK shares against the future exercise of share options and share awards.  The carrying value of £355 million has been deducted from other reserves.  The market value of these shares was £1,025 million. During 2013 GSK purchased £1,504 million of shares to be held as Treasury shares.  At 31 December 2013, the company held 487.4 million Treasury shares at a cost of £6,829 million, which has been deducted from retained earnings.

Contingent liabilities

There were contingent liabilities at 31 December 2013 in respect of guarantees and indemnities entered into as part of the ordinary course of the Group's business.  No material losses are expected to arise from such contingent liabilities.  Provision is made for the outcome of legal and tax disputes where it is both probable that the Group will suffer an outflow of funds and it is possible to make a reliable estimate of that outflow.  Descriptions of the significant legal and tax disputes to which the Group is a party are set out on page 41.

Business acquisitions and disposals

On 29 May 2013, GSK completed the acquisition of 100% of the issued share capital of Okairos AG.  Okairos AG is a European based biopharmaceutical company focused on the development of a specific vaccine technology in the prophylactic and therapeutic fields.  Total consideration was £205 million, net of cash acquired.  This represented goodwill of £37 million, intangible assets of £190 million, a deferred tax liability of £23 million and other net assets of £1 million and included total fair value adjustments of £204 million.  These amounts are provisional and may be subject to change.  On 31 December 2013, GSK completed the disposal of the Lucozade and Ribena business to Suntory for consideration of £1,352 million. On 31 December 2013, GSK completed the sale of the worldwide intellectual property rights (excluding certain EMAP markets) of the anti-coagulant products business to the Aspen Group, together with related inventory and a manufacturing site for consideration of £732 million, of which £233 million has been deferred and is receivable in 2014.

Related party transactions

The Group's significant related parties are its joint ventures and associates as disclosed in the Annual Report 2012, apart from ChemoCentryx, a US biopharmaceutical company, which is now being treated as an equity investment. As noted above, GSK sold the intellectual property rights relating to our anti-coagulant products business to an associate, Aspen during the year.  In addition, the Group's shareholding in this associate was reduced following the sale of 28.2 million ordinary shares for £429 million.  At 31 December 2013, GSK held 56.5 million shares, representing 12.4% of the issued share capital. There were no material transactions with Directors during the year.

Reconciliation of cash flow to movements in net debt

		2013 £m	2012 £m
		------------	------------
Net debt at beginning of the year		(14,037)	(9,003)
Increase/(decrease) in cash and bank overdrafts		1,473	(1,607)
Cash inflow from liquid investments		(15)	(224)
Net increase in long-term loans		(1,913)	(4,430)
Net repayment of short-term loans		1,872	816
Net repayment of obligations under finance leases		31	35
Net non-cash funds of subsidiaries acquired		(6)	(3)
Exchange adjustments		(34)	385
Other non-cash movements		(16)	(6)
		------------	------------
Decrease/(increase) in net debt		1,392	(5,034)
		------------	------------
Net debt at end of the year		(12,645)	(14,037)
		------------	------------

Core results reconciliations

The reconciliations between core results and total results for 2013 and 2012 and also Q4 2013 and Q4 2012 are set out below.

Income statement - Core results reconciliation Year ended 31 December 2013

	Core results £m	Intangible amortisation £m	Intangible impairment £m	Major restructuring £m	Legal costs £m	Acquisition accounting and other £m	Total results £m
	------------	------------	------------	------------	------------	------------	------------
Turnover	26,505						26,505
Cost of sales	(7,549)	(450)	(408)	(178)			(8,585)
	------------	------------	------------	------------	------------	------------	------------
Gross profit	18,956	(450)	(408)	(178)	-		17,920
Selling, general and administration	(7,928)			(300)	(252)		(8,480)
Research and development	(3,400)	(97)	(331)	(39)		(56)	(3,923)
Royalty income	387						387
Other operating income/(expense)	-					1,124	1,124
	------------	------------	------------	------------	------------	------------	------------
Operating profit	8,015	(547)	(739)	(517)	(252)	1,068	7,028
Net finance costs	(692)			(6)		(8)	(706)
Profit on disposal of interest in associates and joint ventures	-					282	282
Share of after tax profits    of associates and joint ventures	43						43
	------------	------------	------------	------------	------------	------------	------------
Profit before taxation	7,366	(547)	(739)	(523)	(252)	1,342	6,647
Taxation	(1,695)	149	226	145	9	147	(1,019)
Tax rate %	23.0%						15.3%
	------------	------------	------------	------------	------------	------------	------------
Profit after taxation	5,671	(398)	(513)	(378)	(243)	1,489	5,628
	------------	------------	------------	------------	------------	------------	------------
Profit attributable to    non-controlling interests	250					(58)	192
Profit attributable to    shareholders	5,421	(398)	(513)	(378)	(243)	1,547	5,436
	------------	------------	------------	------------	------------	------------	------------
Earnings per share	112.2p	(8.2)p	(10.7)p	(7.8)p	(5.0)p	32.0p	112.5p
	------------	------------	------------	------------	------------	------------	------------
Weighted average number    of shares (millions)	4,831						4,831
	------------						------------

Income statement - Core results reconciliation Year ended 31 December 2012

	Core results (restated) £m	Intangible amortisation £m	Intangible impairment £m	Major restructuring £m	Legal costs £m	Acquisition accounting and other £m	Total results (restated) £m
	------------	------------	------------	------------	------------	------------	------------
Turnover	26,431						26,431
Cost of sales	(7,109)	(378)	(309)	(128)		(1)	(7,925)
	------------	------------	------------	------------	------------	------------	------------
Gross profit	19,322	(378)	(309)	(128)		(1)	18,506
Selling, general and administration	(7,905)			(418)	(436)	(30)	(8,789)
Research and development	(3,485)	(99)	(384)	(11)			(3,979)
Royalty income	306						306
Other operating income						1,256	1,256
	------------	------------	------------	------------	------------	------------	------------
Operating profit	8,238	(477)	(693)	(557)	(436)	1,225	7,300
Net finance costs	(724)			(1)		(4)	(729)
Share of after tax profits of    associates and joint ventures	29						29
	------------	------------	------------	------------	------------	------------	------------
Profit before taxation	7,543	(477)	(693)	(558)	(436)	1,221	6,600
Taxation	(1,838)	145	196	(285)	150	(290)	(1,922)
Tax rate %	24.4%						29.1%
	------------	------------	------------	------------	------------	------------	------------
Profit after taxation	5,705	(332)	(497)	(843)	(286)	931	4,678
	------------	------------	------------	------------	------------	------------	------------
Profit attributable to    non-controlling interests	235		(136)	10		70	179
Profit attributable to shareholders	5,470	(332)	(361)	(853)	(286)	861	4,499
	------------	------------	------------	------------	------------	------------	------------
Earnings per share	111.4p	(6.8)p	(7.3)p	(17.4)p	(5.8)p	17.5p	91.6p
	------------	------------	------------	------------	------------	------------	------------
Weighted average number of    shares (millions)	4,912						4,912
	------------						------------

Income statement - Core results reconciliation Three months ended 31 December 2013

	Core results £m	Intangible amortisation £m	Intangible impairment £m	Major restructuring £m	Legal costs £m	Acquisition accounting and other £m	Total results £m
	------------	------------	------------	------------	------------	------------	------------
Turnover	6,906						6,906
Cost of sales	(2,006)	(127)	(327)	(66)			(2,526)
	------------	------------	------------	------------	------------	------------	------------
Gross profit	4,900	(127)	(327)	(66)			4,380
Selling, general and administration	(2,005)			(107)	(89)	1	(2,200)
Research and development	(905)	(23)	(126)	(2)		(14)	(1,070)
Royalty income	98						98
Other operating income/(expense)						1,233	1,233
	------------	------------	------------	------------	------------	------------	------------
Operating profit	2,088	(150)	(453)	(175)	(89)	1,220	2,441
Net finance costs	(155)			(2)		(2)	(159)
Profit on disposal of associates    and joint ventures	-					253	253
Share of after tax profits    of associates and joint ventures	11						11
	------------	------------	------------	------------	------------	------------	------------
Profit before taxation	1,944	(150)	(453)	(177)	(89)	1,471	2,546
Taxation	(431)	41	154	110	(17)	102	(41)
Tax rate %	22.2%						1.6%
	------------	------------	------------	------------	------------	------------	------------
Profit after taxation	1,513	(109)	(299)	(67)	(106)	1,573	2,505
	------------	------------	------------	------------	------------	------------	------------
Profit attributable to    non-controlling interests	69					(25)	44
Profit attributable to    shareholders	1,444	(109)	(299)	(67)	(106)	1,598	2,461
	------------	------------	------------	------------	------------	------------	------------
Earnings per share	30.1p	(2.3)p	(6.2)p	(1.4)p	(2.2)p	33.3p	51.3p
	------------	------------	------------	------------	------------	------------	------------
Weighted average number    of shares (millions)	4,798						4,798
	------------						------------

Income statement - Core results reconciliation Three months ended 31 December 2012

	Core results (restated) £m	Intangible amortisation £m	Intangible impairment £m	Major restructuring £m	Legal costs £m	Acquisition accounting and other £m	Total results (restated) £m
	------------	------------	------------	------------	------------	------------	------------
Turnover	6,802						6,802
Cost of sales	(1,837)	(107)	(13)	(61)			(2,018)
	------------	------------	------------	------------	------------	------------	------------
Gross profit	4,965	(107)	(13)	(61)			4,784
Selling, general and administration	(1,940)			(181)	(91)	1	(2,211)
Research and development	(837)	(24)	(280)	(3)			(1,144)
Royalty income	76						76
Other operating income/(expense)						412	412
	------------	------------	------------	------------	------------	------------	------------
Operating profit	2,264	(131)	(293)	(245)	(91)	413	1,917
Net finance costs	(194)			(1)		(4)	(199)
Share of after tax profits    of associates and joint ventures	10						10
	------------	------------	------------	------------	------------	------------	------------
Profit before taxation	2,080	(131)	(293)	(246)	(91)	409	1,728
Taxation	(461)	40	77	(351)	(3)	(207)	(905)
Tax rate %	22.2%						52.4%
	------------	------------	------------	------------	------------	------------	------------
Profit after taxation	1,619	(91)	(216)	(597)	(94)	202	823
	------------	------------	------------	------------	------------	------------	------------
Profit attributable to    non-controlling interests	58		(136)			53	(25)
Profit attributable to    shareholders	1,561	(91)	(80)	(597)	(94)	149	848
	------------	------------	------------	------------	------------	------------	------------
Earnings per share	32.2p	(1.9)p	(1.7)p	(12.3)p	(1.9)p	3.1p	17.5p
	------------	------------	------------	------------	------------	------------	------------
Weighted average number    of shares (millions)	4,843						4,843
	------------						------------

Group reporting in 2014

During 2014, GSK intends to report core results performance measured against 2013 core results excluding divestments completed during 2013.  Summary restated 2013 core results excluding divestments for the full year 2013 and Q4 2013 are set out below.  Fuller details for each quarter will be published during Q1 2014.

Core results excluding divestments completed during 2013
	2013 £m	Q4 2013 £m
	------------	------------
Turnover	25,602	6,700
Cost of sales	(7,075)	(1,903)
Selling, general and administration	(7,749)	(1,971)
Research and development	(3,394)	(904)
Royalty income	387	98
	------------	------------
Operating profit	7,771	2,020
	------------	------------
Profit before tax	7,122	1,876
Profit after tax	5,487	1,462
Profit attributable to shareholders	5,237	1,393
	------------	------------
Earnings per share (pence)	108.4p	29.0p
	------------	------------

In addition, from 1 January 2014, the Group will report the Established Products Portfolio of over 50 tail brands as a separate segment.  The full year 2013 and Q4 2013 turnover restated onto this basis is set out below.  Fuller details for each quarter will be published during Q1 2014.

Group turnover by segment - restated for creation of Established Products Portfolio
		2013		Q4 2013
		-----------------------------------		-----------------------------------
		£m	Growth CER%	£m	Growth CER%
		------------	------------	------------	------------
Pharmaceuticals and Vaccines
-	US	5,845	4	1,525	10
-	Europe	4,226	3	1,099	-
-	EMAP	3,473	4	1,011	9
-	Japan	1,058	6	316	26
-	ViiV Healthcare	1,386	-	385	15
-	Established Products	4,215	(9)	1,024	(9)
-	Other trading and unallocated pharmaceuticals	1,115	11	328	26
		------------	------------	------------	------------
Pharmaceuticals and Vaccines		21,318	1	5,688	6
Consumer Healthcare		5,187	2	1,218	-
		------------	------------	------------	------------
		26,505	1	6,906	5
		------------	------------	------------	------------

Pharmaceuticals and Vaccines turnover - restated for creation of Established Products Portfolio Year ended 31 December 2013

	Total		USA		Europe		EMAP		Rest of World
	---------------------------		---------------------------		--------------------------		-----------------------------		---------------------------
	£m	CER%	£m	CER%	£m	CER%	£m	CER%	£m	CER%
	----------	----------	----------	----------	----------	----------	----------	----------	----------	----------
Innovative Products	15,717	4	5,845	4	4,226	3	3,473	4	2,173	8
			----------	----------	----------	----------	----------	----------	----------	----------
ViiV Healthcare (HIV)	1,386	-
Established Products	4,215	(9)
	----------	----------
	21,318	1
	----------	----------
Established Products
Arixtra	167	(15)	50	(26)	84	(12)	28	-	5	(13)
Coreg	131	(2)	130	(2)	-	-	-	-	1	-
Fraxiparine	221	(7)	-	-	138	(8)	83	(6)	-	-
Hepsera	96	(21)	-	-	-	-	70	(28)	26	-
Imigran/Imitrex	188	1	80	11	63	(7)	7	-	38	(5)
Lamictal	557	(7)	276	(18)	110	(4)	78	8	93	21
Lovaza	584	(5)	581	(5)	-	-	-	-	3	-
Requip	125	(18)	7	(63)	52	(33)	14	-	52	15
Serevent	129	(10)	51	(2)	55	(17)	4	33	19	(15)
Seroxat/Paxil	285	(16)	-	-	53	(11)	79	(4)	153	(23)
Valtrex	224	(2)	45	26	29	(15)	40	11	110	(10)
Zeffix	182	(26)	13	(13)	12	(25)	140	(28)	17	(17)
Zovirax	81	(4)	1	(67)	19	(10)	35	3	26	(3)
Other	1,245	(6)	113	(5)	325	(14)	647	3	160	(20)
	----------	----------	----------	----------	----------	----------	----------	----------	----------	----------
	4,215	(9)	1,347	(8)	940	(13)	1,225	(4)	703	(11)
	----------	----------	----------	----------	----------	----------	----------	----------	----------	----------
Established Products
excluding divestments	3,869	(8)	1,297	(7)	718	(14)	1,157	(5)	697	(10)
	----------	----------	----------	----------	----------	----------	----------	----------	----------	----------

 

END

 

 

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