Director Shareholding

GlaxoSmithKline PLC 23 May 2005 Director's Interests I give below details of changes in directors' interests in the Ordinary Shares of GlaxoSmithKline plc. 18 May 2005 The Administrators of the SmithKline Beecham Employee Benefit Trust ("the Trust") notified the Company on 23 May 2005 that 91 Ordinary shares in the Company had been sold on behalf of a participant in the GlaxoSmithKline Bonus Investment Plan at a price of £13.70 per share. The Administrators of the Trust also notified the Company on 23 May 2005 that 329 Ordinary shares had been transferred from the Trust to a participant in the GlaxoSmithKline Bonus Investment Plan. The Administrators of the Trust also notified the Company on 23 May 2005 that 188 Ordinary shares in the Company had been sold on behalf of a participant in the GlaxoSmithKline Annual Investment Plan at a price of £13.70 per share. The Trust also notified the Company on 23 May 2005 that 682 Ordinary shares had been transferred from the Trust to participants in the GlaxoSmithKline Annual Investment Plan. 18 May 2005 The Trust is a discretionary fund of which all non US employees or former employees of GlaxoSmithKline plc and its subsidiaries are potential beneficiaries. One of the Company's directors, Mr J S Heslop is therefore interested in the shares held in the fund from time to time in the same way as other non US employees or former employees of GlaxoSmithKline plc and its subsidiaries. S M Bicknell Company Secretary 23 May 2005 This information is provided by RNS The company news service from the London Stock Exchange

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