Director Shareholding

GlaxoSmithKline PLC
16 May 2005


Director's Interests



I give below details of changes in directors' interests in the Ordinary Shares
of GlaxoSmithKline plc.




10 May 2005                The Administrators of the SmithKline Beecham Employee Benefit Trust ("the
                           Trust") notified the Company on 16 May 2005 that 2,004 Ordinary shares in the
                           Company had been transferred from the Trust to a participant in the
                           GlaxoSmithKline Bonus Investment Plan.



                           The Administrators of the Trust also notified the Company on 16 May 2005 that
                           3,600 Ordinary shares in the Company had been transferred from the Trust to
                           participants in the GlaxoSmithKline Annual Investment Plan.


10 May 2005




The Trust is a discretionary fund of which all non US employees or former
employees of GlaxoSmithKline plc and its subsidiaries are potential
beneficiaries. One of the Company's directors, Mr J S Heslop is therefore
interested in the shares held in the fund from time to time in the same way as
other non US employees or former employees of GlaxoSmithKline plc and its
subsidiaries.





S M Bicknell

Company Secretary


16 May 2005




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