Director Shareholding

GlaxoSmithKline PLC
28 February 2005




                              Director's Interests

Following a re-valuation of the cash element of the notional investment held
within the US Retirement Savings Plan, which is notionally held in GSK Ordinary
Share ADRs, the Administrators of the Plan notified GlaxoSmithKline plc and the
under-mentioned Directors on 28 February 2005 of an increase in the notional
allocation of Ordinary Share ADRs on 25 February 2005 at a price of $48.64 per
share:-



Dr J P Garnier                40

Dr T Yamada                   10



S M Bicknell
Company Secretary
28 February 2005




                      This information is provided by RNS
            The company news service from the London Stock Exchange