Director Shareholding

GlaxoSmithKline PLC
28 September 2004


                              Directors' Interests





I give below details of changes in interests in the Ordinary Shares of
GlaxoSmithKline plc in respect of the undermentioned directors:


Sir Christopher Hogg acquired a beneficial interest in 32 Ordinary Shares
purchased under a Personal Equity Plan on 27 September 2004 at £11.79.



Mr J D Coombe acquired a beneficial interest in 10 Ordinary Shares purchased
under a Personal Equity Plan on 27 September 2004 at £11.79.



Mrs G A Coombe (wife of Mr J D Coombe) acquired a beneficial interest in 8
Ordinary Shares purchased under a Personal Equity Plan on 27 September 2004 at
£11.79.



Sir Peter Job acquired a beneficial interest in 1 Ordinary Share purchased under
a Personal Equity Plan on 27 September 2004 at £11.79.


The Directors and the Company were advised of these transactions on 28 September
2004.




S M Bicknell
Company Secretary



28 September 2004




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