Director Shareholding

GlaxoSmithKline PLC
01 October 2004

                              Directors' Interests

I give below details of changes in interests in the Ordinary Shares of
GlaxoSmithKline plc in respect of the under-mentioned Directors or connected
persons, arising from the purchase of Ordinary Shares on 30 September 2004 under
a Single Company ISA at a price of £12.19 per Ordinary Share:

Mr J D Coombe                                 4

Mrs G A Coombe                                4
  (wife of Mr J D Coombe)

Sir Peter Job                                 6

The Company and Directors were advised of this information on 1 October 2004.

S M Bicknell
Company Secretary

1 October 2004

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