Director Shareholding

GlaxoSmithKline PLC
27 July 2004





Directors' Interests



I give below details of changes in directors' interests in the Ordinary Shares
of GlaxoSmithKline plc.




26 July 2004               The Administrators of the SmithKline Beecham Employee Benefit Trust ("the
                           Trust") notified the Company on 27 July 2004 that 15,427 Ordinary shares had
                           been transferred from the Trust to participants in the Annual Investment Plan.




The Trust is a discretionary fund of which all non US employees or former
employees of GlaxoSmithKline plc and its subsidiaries are potential
beneficiaries. One of the Company's directors, John Coombe is therefore
interested in the shares held in the fund from time to time in the same way as
other non US employees or former employees of GlaxoSmithKline plc and its
subsidiaries.





S M Bicknell
Company Secretary



27 July 2004




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