Director Shareholding

GlaxoSmithKline PLC
30 September 2003

                              Directors' Interests




I give below details of changes in interests in the Ordinary Shares of
GlaxoSmithKline plc in respect of the undermentioned directors:




Sir Christopher Hogg acquired a beneficial interest in 27 Ordinary Shares
purchased under a Personal Equity Plan on 29 September 2003 at £12.75.


Mr J D Coombe acquired a beneficial interest in 8 Ordinary Shares purchased
under a Personal Equity Plan on 29 September 2003 at £12.75.


Mrs G A Coombe (wife of Mr J D Coombe) acquired a beneficial interest in 6
Ordinary Shares purchased under a Personal Equity Plan on 29 September 2003 at
£12.75.


Sir Peter Job acquired a beneficial interest in 1 Ordinary Share purchased under
a Personal Equity Plan on 29 September 2003 at £12.75.




The Directors and the Company were advised of these transactions on 30 September
2003.






S M Bicknell

Company Secretary


30 September 2003



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