Director Shareholding

GlaxoSmithKline PLC
03 October 2003


                             Directors Interests

I give below details of a change in the interests in Ordinary Shares of
GlaxoSmithKline plc in respect of the undermentioned Director arising from the
purchase of Ordinary Shares at a price of £12.65 per Ordinary Share on 2 October
2003 through the Company's ShareReward Plan ("the Plan") which Mr Coombe entered
on 5 October 2001:

Mr J D Coombe                      Acquisition of 3 Ordinary Shares under the 
                                   Dividend Reinvestment element of the Plan 
                                   (Company contribution)

Mr Coombe and the Company were advised of this information on 3 October 2003.


S M Bicknell

Company Secretary


3 October 2003


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