Director Shareholding

GlaxoSmithKline PLC
28 April 2003

                              Directors' Interests


I give below details of changes in directors' interests in the Ordinary Shares
of GlaxoSmithKline plc.



25 April 2003              Abacus (GSK) Trustees Limited, as trustee of the
                           GlaxoSmithKline Employee Trust, ("the GSK Trust"),
                           sold 1,351 Ordinary Shares in the Company at a price
                           of £12.4725 per Ordinary Share on behalf of a
                           participant of the SmithKline Beecham Mid Term
                           Incentive Plan.

                           Abacus (GSK) Trustees Limited, as trustee of the
                           GlaxoSmithKline Employee Trust, ("the GSK Trust"),
                           transferred 1,298 Ordinary Shares in the Company to a
                           participant of the SmithKline Beecham Mid Term
                           Incentive Plan.




The Company was advised of these transactions on 28 April 2003.


The GSK Trust is a discretionary trust of which all employees or former
employees of GlaxoSmithKline plc and its subsidiaries are potential
beneficiaries. Two of the Company's directors, Dr J-P Garnier and Mr J D Coombe
are therefore interested in the shares held in the GSK Trust from time to time
in the same way as other employees or former employees of GlaxoSmithKline plc
and its subsidiaries.


S M Bicknell

Company Secretary


28 April 2003


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