Director Shareholding

GlaxoSmithKline PLC
03 January 2003

                              Directors' Interests

I give below details of changes in directors' interests in the Ordinary Shares
of GlaxoSmithKline plc.

2 January 2003                   The Administrators of the GlaxoSmithKline US Retirement Savings
                                 Plan ("the Plan") notified GlaxoSmithKline plc on 3 January 2003,
                                 that as a result of movement in the fund on the 2 January 2003,
                                 the number of Ordinary Share ADRs held by the fund had decreased
                                 from 18,343,751 to 18,290,955 at an average price of $38.51.


The Plan is a discretionary fund of which all employees or former employees of
GlaxoSmithKline plc and its subsidiaries are potential beneficiaries. Two of the
Company's directors, Dr J P Garnier and Mr J D Coombe are therefore interested
in the shares held in the fund from time to time in the same way as other
employees or former employees of GlaxoSmithKline plc and its subsidiaries.


S M Bicknell

Company Secretary

3 January 2003


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