Director Shareholding

GlaxoSmithKline PLC
11 October 2002



                              Directors' Interests



I give below details of a change in the interests in Ordinary Shares of
GlaxoSmithKline plc in respect of the undermentioned Director arising from the
purchase of Ordinary Shares at a price of £12.7125 per Ordinary Share on 9
October 2002 through the Company's ShareReward Plan ("the Plan") which Mr Coombe
entered on 5 October 2001:



Mr J D Coombe       Acquisition of 9 Ordinary Shares under the partnership
                    element of the Plan (personal contribution)

                    Acquisition of 9 Ordinary Shares under the matching element 
                    of the Plan (Company contribution)



Mr Coombe and the Company were advised of this information on 10 October 2002.






S M Bicknell

Company Secretary


11 October 2002


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