Director Shareholding

GlaxoSmithKline PLC
16 November 2001

                             Directors' Interests



I give below details of changes in directors' interests in the Ordinary Shares
of GlaxoSmithKline plc.



15       The Administrators of the GlaxoSmithKline Retirement Savings Plan
November ('the Plan') notified GlaxoSmithKline plc on the 16 November 2001,
2001     that as a result of movement in the fund on the 15 November 2001, the
         number of Ordinary Share ADRs held by the fund had increased from
         18,544,813 to 18,579,519 at an average price of $52.8500


The Plan is a discretionary fund of which all employees or former employees of
SmithKline Beecham plc and its subsidiaries are potential beneficiaries. One
of the Company's directors, Dr J P Garnier is therefore, interested in the
shares held in the fund from time to time in the same way as other employees
or former employees of SmithKline Beecham plc and its subsidiaries.






S M Bicknell

Company Secretary


16 November 2001