Director Shareholding

GlaxoSmithKline PLC
6 November 2001

                             Directors' Interests



I give below details of changes in directors' interests in the Ordinary Shares
of GlaxoSmithKline plc.


1         The Administrators of the GlaxoSmithKline Retirement Savings Plan
November  formerly the SmithKline Beecham US Retirement Savings Plan ('the
2001      Plan') notified GlaxoSmithKline plc on the 5 November 2001, that as a
          result of movement in the fund on the 1 November 2001, the number of
          Ordinary Share ADRs held by the fund had increased from 18,548,862 to
          18,573,261 at an average price of $54.9500

The Plan is a discretionary fund of which all employees or former employees of
SmithKline Beecham plc and its subsidiaries are potential beneficiaries. One
of the Company's directors, Dr J P Garnier is therefore, interested in the
shares held in the fund from time to time in the same way as other employees
or former employees of SmithKline Beecham plc and its subsidiaries.





S M Bicknell

Company Secretary

6 November 2001