Director Shareholding

GlaxoSmithKline PLC
15 June 2001

                             Directors' Interests



I give below details of changes in directors' interests in the Ordinary Shares
of GlaxoSmithKline plc.

14 June 2001  Abacus (GW) Trustees Limited, as trustee of The Glaxo Wellcome 
              Employee Trust ('the Trust'), transferred 172,895 Ordinary Shares 
              in the Company to participants of the Glaxo Wellcome 1999 Share 
              Option Plans, the Glaxo Wellcome UK Share Option Scheme and the 
              Glaxo Wellcome International Share Option Scheme. The Trust also 
              sold 6,800 Ordinary Shares in the Company at £19.84 per share.

The Company was advised of these transactions on 15 June 2001.

The Trust is a discretionary trust of which all employees or former employees
of Glaxo Wellcome plc and its subsidiaries are potential beneficiaries. Two of
the Company's directors, Sir Richard Sykes and John Coombe are therefore
interested in the shares held in the Trust from time to time in the same way
as other employees or former employees of Glaxo Wellcome plc and its
subsidiaries.


S M Bicknell

Company Secretary


15 June 2001