Director Shareholding

GlaxoSmithKline PLC
23 July 2001

                             Directors' Interests



I give below details of changes in directors' interests in the Ordinary Shares
of GlaxoSmithKline plc.

19    Abacus (GW) Trustees Limited, as trustee of The Glaxo Wellcome Employee
July  Trust ('the Trust'), sold 2,698 Ordinary Shares in the Company at a price
2001  of £19.96 each. The Trust also transferred 63,196 Ordinary Shares in the
      Company to participants of the Glaxo Wellcome 1999 Share Option Plan, The
      Glaxo Wellcome UK Share Option Scheme, The Glaxo Wellcome International
      Share Option Scheme and The Glaxo Wellcome Long Term Incentive Plan.

20    Abacus (GW) Trustees Limited, as trustee of The Glaxo Wellcome Employee
July  Trust, transferred 29,233 Ordinary Shares in the Company to participants
2001  of the Glaxo Wellcome International Share Option Scheme.





The Company was advised of this transaction on 23 July 2001.


The Trust is a discretionary trust of which all employees or former employees
of Glaxo Wellcome plc and its subsidiaries are potential beneficiaries. Two of
the Company's directors, Sir Richard Sykes and John Coombe are therefore
interested in the shares held in the Trust from time to time in the same way
as other employees or former employees of Glaxo Wellcome plc and its
subsidiaries.






S M Bicknell

Company Secretary




23 July 2001