Director Shareholding

GlaxoSmithKline PLC
1 May 2001

                             Directors' Interests

I give below details of changes in directors' interests in the Ordinary Shares
of GlaxoSmithKline plc.

30    Abacus (GW) Trustees Limited, as trustee of The Glaxo Wellcome Employee
April Trust ('the Trust'), transferred 48,925 Ordinary Shares in the Company to
2001  participants of the Glaxo Wellcome UK Share Option Plan, the Glaxo
      Wellcome 1999 Share Option Plan, Glaxo Wellcome International Share
      Option Scheme and the Glaxo Wellcome 1999 Long Term Incentive Plan. The
      Trust also sold 1,291 Ordinary shares in the Company at £18.72 per share
      and 5,041 Ordinary shares in the Company at £18.74 per share.

The Company was advised of these transactions on 1 May 2001.

The Trust is a discretionary trust of which all employees or former employees
of Glaxo Wellcome plc and its subsidiaries are potential beneficiaries. Two of
the Company's directors, Sir Richard Sykes and John Coombe are therefore
interested in the shares held in the Trust from time to time in the same way
as other employees or former employees of Glaxo Wellcome plc and its
subsidiaries.


S M Bicknell

Company Secretary



1 May 2001