Director Shareholding

GlaxoSmithKline PLC
23 January 2001




                             Directors' Interests



I give below details of changes in directors' interests in the Ordinary Shares
of GlaxoSmithKline plc.

22      Abacus (GW) Trustees Limited, as trustee of The Glaxo Wellcome Employee
January Trust ('the Trust'), transferred 18,495 Ordinary Shares in the Company
2001    to participants of the Glaxo Wellcome 1999 Share Option Plan and the
        Glaxo Wellcome International Share Option Scheme. The Trust also sold
        46,342 Ordinary Shares in the company at a price of £17.90 per share.





The Company was advised of this transaction on 23 January 2001.




The Trust is a discretionary trust of which all employees or former employees
of Glaxo Wellcome plc and its subsidiaries are potential beneficiaries. Two of
the Company's directors, Sir Richard Sykes and John Coombe, as directors of
Glaxo Wellcome plc, are therefore interested in the shares held in the Trust
from time to time in the same way as other employees or former employees of
Glaxo Wellcome plc and its subsidiaries.






S M Bicknell

Company Secretary




23 January 2001