Director Shareholding

GlaxoSmithKline PLC
22 January 2001










                             Directors' Interests



I give below details of changes in directors' interests in the Ordinary Shares
of GlaxoSmithKline plc.



18      The Administrators of the SmithKline Beecham US Retirement Savings Plan
January ('the Plan') notified GlaxoSmithKline plc on the 19th January 2001,
2001    that as a result of movement in the fund on the 18th January 2001, the
        number of Ordinary share ADRs held by the fund had increased from
        17,663,906 to 17,677,639 at an average price of $53.3750.


The Plan is a discretionary fund of which all employees or former employees of
SmithKline Beecham plc and its subsidiaries are potential beneficiaries. One
of the Company's directors, Dr J P Garnier, as a director of SmithKline
Beecham plc, is therefore, interested in the shares held in the fund from time
to time in the same way as other employees or former employees of SmithKline
Beecham plc and its subsidiaries.






S M Bicknell

Company Secretary


22nd January 2001