Director/PDMR Shareholding

GlaxoSmithKline PLC
19 April 2006



   Notification of Transactions of Directors, Persons Discharging Managerial
                      Responsibility or Connected Persons


I give below details of changes in the interests of Directors, Persons
Discharging Managerial Responsibility or Connected Persons in the Ordinary
Shares of GlaxoSmithKline plc.


   13 April 2006         Abacus (GSK) Trustees Limited, as trustee of the
                         GlaxoSmithKline Employee Trust, ("the GSK Trust"), 
                         transferred 48,000 Ordinary Shares in the Company to 
                         participants in the SmithKline Beecham Employee Share 
                         Option Plan 1991.


   17 April 2006         The GSK Trust sold 1,025 American Depositary Shares 
                         (ADSs) in the Company on behalf of participants in the 
                         SmithKline Beecham Mid-Term Incentive Plan at a price 
                         of $52.40 per ADS.


   17 April 2006         The GSK Trust transferred 2,193 ADSs in the Company to
                         participants in the SmithKline Beecham Mid-Term 
                         Incentive Plan.


The Company was advised of these transactions on 18 April 2006.

The GSK Trust is a discretionary trust of which all employees or former
employees of GlaxoSmithKline plc and its subsidiaries are potential
beneficiaries. Three of the Company's directors, Dr J-P Garnier, Dr T Yamada and
Mr J S Heslop are therefore interested in the shares held in the GSK Trust from
time to time in the same way as other employees or former employees of
GlaxoSmithKline plc and its subsidiaries.

This notification relates to a transaction notified in accordance with
Disclosure Rule 3.1.4R(1)(b).


S M Bicknell
Company Secretary

19 April 2006


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