Holding in Company

Cambridge Antibody Tech Group PLC
30 August 2000


NOTIFICATIONS UNDER SECTIONS 198 TO 202 -- UK COMPANIES ACT

1. Company in which shares are held:   CAMBRIDGE ANTIBODY TECH GROUP PLC

2. Notifiable Interest:                ORDINARY SHARES

     A     FMR Corp
           82 Devonshire Street
           Boston, MA 02109

           Parent holding company of Fidelity Management & Research Company 
           (FMRCO), investment manager for US mutual funds, and Fidelity        
          Management Trust Company (FMTC), a US state chartered bank which      
         acts as trustee or investment manager of various pension and trust     
        accounts. (See Schedule A for listing of Registered Shareholders 
           and their holdings.)

     B     Fidelity International Limited (FIL)
           P.O. BOX HM 670
           Hamilton HMCX, Bermuda

           Parent holding company for various direct and indirect subsidiaries,
           including Fidelity Investment Services Ltd. (FISL) and Fidelity      
          Pension Management (FPM), investment managers for various non-US      
         investment companies and institutional clients. (See Schedule A for    
        listing of Registered Shareholders and their holdings).

3.     The notifiable interests also comprise the notifiable interest of

           Mr Edward C Johnson 3d
           82 Devonshire Street
           Boston, MA 02109

           A principal shareholder of FMR Corp. and Fidelity International      
          Limited.

4.     The notifiable interests include interest held on behalf of authorized
       unit trust schemes in the U.K. notwithstanding the exemption from 
       reporting pursuant to Section 209 (1) (e) of the Companies Act 1985.

5.     These notifications of disclosable interests constitute separate
       notifications of interest in the shares and are combined solely for 
       the purposes of clarity. Nothing herein should be taken to indicate 
       that FMR Corp. and its direct and indirect subsidiaries, 
       Fidelity International Limited and its direct and indirect subsidiaries
       or Mr Edward C Johnson 3d act as a group or in concert in respect of 
       the disclosed interests, or that they are required to submit these 
       notifications on a joint basis.

6.     The disclosable interests arise under section 208(4) (b) of the Act,
       namely where a person, not being the registered holder, is entitled
       to exercise a right conferred by the holding of the shares or to 
       control the exercise of such rights, or under section 203 of the Act
       respectively.


SCHEDULE A     

SECURITY: Cambridge Antibody Tech Group Plc

                      SHARES HELD   MANAGEMENT   NOMINEE/REGISTERED
                                     COMPANY     NAME
(Ordinary Shares)       
                         684,055     FMRCO       CHASE NOMINEES LIMITED
                          83,800     FMRCO       STATE STREET NOMINEES LIMITED
                         680,296     FMRCO       LLOYDS BANK NOMINEES LIMITED
                           4,482     FIL          

TOTAL ORDINARY SHARES: 1,452,633

CURRENT OWNERSHIP PERCENTAGE:  4.21%

SHARES IN ISSUE:      34,530,994

CHANGE IN HOLDINGS SINCE
 LAST FILING:           +406,871 ORDINARY SHARES 1.18%