Director/PDMR Shareholding

AstraZeneca PLC
28 February 2006


Transaction by Persons Discharging Managerial Responsibilities
Disclosure Rules DR 3.1.2R


We hereby inform you that on 24 February 2006, the following individuals, who
are all persons discharging managerial responsibilities, acquired an interest in
the USD0.25 Ordinary Shares of AstraZeneca PLC.  The interest arises as a result
of the previously disclosed arrangements relating to the payment of annual
bonuses for 2005 whereby each individual is required to defer a portion of the
bonus earned into shares for a period of three years.  The shares were allocated
at a price of 2639 pence per share.  The individuals will become beneficially
entitled to these shares on 24 February 2009.

                                    Number of shares
Name                                allocated

B Angelici                          2,448
A Bloxham                           1,590
J Lundberg                          2,059
M Nicklasson                        2,074
B Thorpe                            1,869


G H R Musker
Company Secretary

28 February 2006


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