Director/PDMR Shareholding

AstraZeneca PLC
24 January 2006

Dealing by Directors

Companies Act 1985 Sections 324/329



Transaction by Persons Discharging Managerial Responsibilities

Disclosure Rules DR 3.1.2R



We hereby inform you that, on 23 January 2006, Dr H L Mogren, a Director of the
Company, ceased to have an interest in an option over 9,826 AstraZeneca PLC
Ordinary Shares of USD0.25 each following its expiry.



The option was originally granted to Dr Mogren in 1999 for a period of seven
years over shares in Astra AB under the Astra Shareholder Value Incentive Plan.
The option was subsequently converted into an option over Ordinary Shares in
AstraZeneca PLC in April 1999.  The option has not been exercised by Dr Mogren
and has consequently expired on reaching the seventh anniversary of the date of
grant.  Details of the option are as follows:-


Number of AstraZeneca shares over which     Effective option     Market price of AstraZeneca shares
option was held                             price per share      when option expired


9,826                                       441.78SEK            356.50SEK





Following the expiry of this option, Dr Mogren holds options over 244,896
Ordinary Shares of AstraZeneca PLC.



G H R Musker

Company Secretary

24 January 2006


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