Notifiable Interest

Proteome Science PLC ("the Company")                      

                              Notifiable Interest                              

A form TR-1 containing the following information has been received by the
Company.

TR-1 notification of major interests in shares

1. Identity of the issuer or the underlying issuer of existing shares to which
voting rights are attached:

Proteome Science PLC

2. Reason for the notification

Acquistion or disposal of voting rights

3. Full name of person(s) subject to the notification obligation:

Fidelity International Limited (FIL)

4. Full name of shareholder(s) (if different from 3):

See attached schedule

5. Date of the transaction (and date on which the threshold is crossed or
reached if different):

8 May 2007

6. Date on which issuer notified:

10 May 2007

7. Threshold(s) that is/are crossed or reached:

5%

8. Notified details:

A: Voting rights attached to shares

Class/type of Situation previous   Resulting situation after the triggering    
shares        to Triggering        transaction                                 
              transaction                                                      
if possible                        Notification required under DTR transitional
using ISIN                         provision 7                                 
CODE                                                                           
              Number of Number of  Number  Number of voting   % of voting      
              Shares    Voting     of      rights             rights           
                        Rights     shares                                      
                                                                               
                                   Direct  Direct  Indirect   Direct  Indirect 
                                                                               
ISIN          6,679,879 6,679,879                  3,844,823            2.93%  
                                                                               
GB0003104196                                                                   

B: Financial Instruments

Resulting situation after the triggering transaction                         
                                                                             
Type of       Expiration     Exercise/      Number of voting  % of voting    
financial     date           Conversion     rights that may   rights         
instrument                   Period/ Date   be acquired if                   
                                            the instrument is                
                                            exercised/                       
                                            converted                        
                                                                             

Total (A+B)

Number of voting rights                % of voting rights                    
                                                                             
       3,844,823                            2.93%                 

9. Chain of controlled undertakings through which the voting rights and/or the
financial instruments are effectively held, if applicable:

Management Company        Shares Held               Nominee                  
                                                                             
FISL                      1,626,368                 JP Morgan, Bournemouth   
                                                                             
(Fidelity Investment                                                         
Services Ltd)                                                                
                                                                             
FIL                       1,349,412                 JP Morgan, Bournemouth   
                                                                             
(Fidelity International                                                      
Ltd)                                                                         
                                                                             
FIL                       869,043                   Brown Bros Harrimn Ltd   
                                                    Lux                      
(Fidelity International                                                      
Ltd)                                                                         

10. Name of the Proxy holder:

Fidelity International Limited (FIL)

11. Number of voting rights proxy holder will cease to hold:

2,835,056

12. Date on which proxy holder will cease to hold voting rights:

8 May 2007

13. Additional information:

14. Contact name - James Malthouse

15. Contact number - 01932 865065