Notifiable Interest

Proteome Sciences PLC ("the Company")                     

                              Notifiable Interest                              

A form TR-1 containing the following information has been received by the
Company.

TR-1 notification of major interests in shares

1. Identity of the issuer or the underlying issuer of existing shares to which
voting rights are attached:

Proteome Sciences Plc

2. Reason for the notification

Acquisition or disposal of voting rights

3. Full name of person(s) subject to the notification obligation:

Deutsche Bank AG

4. Full name of shareholder(s) (if different from 3):

N/A

5. Date of the transaction (and date on which the threshold is crossed or
reached if different):

27 June 2008

6. Date on which issuer notified:

30 June 2008

7. Threshold(s) that is/are crossed or reached:

3%

8. Notified details:

A: Voting rights attached to shares

Class/type of Situation       Resulting situation after the triggering         
shares        previous to     transaction                                      
              Triggering                                                       
if possible   transaction     Notification required under DTR transitional     
using ISIN                    provision 7                                      
CODE                                                                           
              Number  Number  Number of  Number of voting     % of voting      
              of      of      shares     rights               rights           
              Shares  Voting                                                   
                      Rights  Direct     Direct     Indirect  Direct  Indirect 
                                                                               
GB0003104196  Below   Below   4,019,397  4,019,397            3.03%            
              3%      3%                                                       

B: Financial Instruments

Resulting situation after the triggering transaction                         
                                                                             
Type of       Expiration     Exercise/      Number of voting  % of voting    
financial     date           Conversion     rights that may   rights         
instrument                   Period/ Date   be acquired if                   
                                            the instrument is                
                                            exercised/                       
                                            converted                        
                                                                             

Total (A+B)

Number of voting rights                % of voting rights                    
                                                                             
4,019,397                              3.03%                                 

9. Chain of controlled undertakings through which the voting rights and/or the
financial instruments are effectively held, if applicable:

N/A

10. Name of the Proxy holder:

N/A

11. Number of voting rights proxy holder will cease to hold:

N/A

12. Date on which proxy holder will cease to hold voting rights:

N/A

13. Additional information:

N/A

14. Contact name:

David Lindsay/Andrew Anderson

15. Contact telephone number:

+00 44 207 545 8533/8532