Notifiable Interest

Proteome Sciences PLC ("the Company")                     

                              Notifiable Interest                              

                                                                               

A form TR-1 containing the following information has been received by the
Company.

TR-1 notification of major interests in shares

1. Identity of the issuer or the underlying issuer of existing shares to which
voting rights are attached:

Proteome Sciences PLC

2. Reason for the notification

An acquisition or disposal of voting rights

3. Full name of person(s) subject to the notification obligation:

Sanofi-Aventis Deutschland GmbH

4. Full name of shareholder(s) (if different from 3):

N/A

5. Date of the transaction (and date on which the threshold is crossed or
reached if different):

11 July 2007

6. Date on which issuer notified:

12 July 2007

7. Threshold(s) that is/are crossed or reached:

11%

8. Notified details:

A: Voting rights attached to shares

Class/type   Situation previous to          Resulting situation after the triggering      
of shares    Triggering transaction         transaction                          
if possible                                 Notification required under DTR transitional  
using ISIN                                  provision 7                                   
CODE                                                                             
                Number of     Number of     Number of     Number of voting          % of voting    
                Shares        Voting        shares        rights                    rights         
                              Rights                                                   
                                                                                 
                                                                                 
                                            Direct        Direct        Indirect    Direct    Indirect
                                                                                 
                                                                                 
                                                                                 
GB0003104196    14,982,811    14,982,811    13,663,380    13,663,380                 10.39%         
                                                                                 

B: Financial Instruments

Resulting situation after the triggering transaction                           
                                                                               
                                                                               
Type of     Expiration Exercise/     Number of voting rights that may   % of   
financial   date       Conversion    be acquired if the instrument is   voting 
instrument             Period/ Date  exercised/converted
                                               
                                                                               
N/A         N/A        N/A           N/A                                N/A    
                                                                               

Total (A+B)

Number of voting rights % of voting rights
   
13,663,380              10.39%            
 

9. Chain of controlled undertakings through which the voting rights and/or the
financial instruments are effectively held, if applicable:

N/A

10. Name of the Proxy holder:

N/A

11. Number of voting rights proxy holder will cease to hold:

N/A

12. Date on which proxy holder will cease to hold voting rights:

N/A

13. Additional information:

N/A

14. Contact name:

Juergen Blieke or Reiner May

15. Contact telephone number:

0049 69 305 4703 or 0049 69 305 80202