Holding(s) in Company

Oxford Instruments plc has been notified today, pursuant to Section 198 of the
Companies Act 1985, that HBOS plc and its subsidiaries have a material interest
of 2,071,227 Ordinary £0.05p shares in our Company, which represents 4.32% of
the shares in issue.

The shares to which this notification relates are registered as follows:

No of Shares       Fund                      Registered Holder               
                                                                             
303,000       SJP RF32        HSBC Global Custody Nominees (UK) Ltd a/c      
                              872859                                         
                                                                             
180,227       SJP RF42        HSBC Global Custody Nominees (UK) Ltd a/c      
                              872860                                         
                                                                             
74,000        SJPI RF59       HSBC Global Custody Nominees (UK) Ltd a/c      
                              823861                                         
                                                                             
509,000       SJPI RF62       HSBC Global Custody Nominees (UK) Ltd a/c      
                              823770