Holding(s) in Company

The Company has been notified today that GAM London Limited has a notifiable
interest in 3,727,227 Ordinary Shares of 5p each which, represents 7.777% of
the issued share capital of Oxford Instruments plc.

The shares to which this notification relates are registered as follows:

Holding    Owned By                     Advised By            %          
                                                                         
830,000    Sterling Managed Fund        GAM London Limited    1.732      
                                                                         
119,000    US Dollar Managed Fund       GAM London Limited    0.248      
                                                                         
703,000    GAM International Growth     GAM London Limited    1.467      
           Fund                                                          
                                                                         
451,000    GAM UK Diversified           GAM London Limited    0.941      
                                                                         
74,000     GAM Exempt Trust - U.K.      GAM London Limited    0.154      
           Opportunities                                                 
                                                                         
684,000    JRA/GAM Managed - Life       GAM London Limited    1.427      
                                                                         
438,227    JRA/GAM Managed - Pension    GAM London Limited    0.914      
                                                                         
428,000    St James's Place Recovery    GAM London Limited    0.893      
           Unit Trust                                                    
                                                                         
3,727,227                                                     7.777