Holding(s) in Company

For filings with the FCA include the annex For filings with issuer exclude the annex TR-1: NOTIFICATION OF MAJOR INTEREST IN SHARESi 1. Identity of the issuer or the underlying issuer of existing shares The Biotech Growth to which voting rights are attached:ii Trust PLC 2 Reason for the notification (please tick the appropriate box or boxes): An acquisition or disposal of voting rights No An acquisition or disposal of qualifying financial instruments which may result No in the acquisition of shares already issued to which voting rights are attached An acquisition or disposal of instruments with similar economic effect to No qualifying financial instruments An event changing the breakdown of voting rights No Other (please specify): Market Purchase of Shares by Company Yes 3. Full name of person(s) subject to the notification East Riding of Yorkshire obligation:iii Council 4. Full name of shareholder(s) (if different from 3.):iv State Street Nominees Limited 5. Date of the transaction and date on which the threshold is 3 October 2014 crossed or reached: v 6. Date on which issuer notified: 17 October 2014 7. Threshold(s) that is/are crossed or reached: vi, vii 8.00% 8. Notified details: A: Voting rights attached to shares viii, ix Class/type of Situation previous Resulting situation after shares to the triggering the triggering transaction transaction if possible using Number Number % of voting the ISIN CODE Number of Number of rights x of Voting of voting Shares Rights shares rights Direct Direct xi Indirect xii Direct Indirect 25p Ordinary 5,100,000 5,100,000 5,100,000 5,100,000 N/A 8.00% N/A GB0000385517 B: Qualifying Financial Instruments Resulting situation after the triggering transaction Type of financial Expiration Exercise/ Number of voting % of voting instrument date xiii Conversion Period xiv rights that may be rights acquired if the instrument is exercised/ converted. N/A N/A N/A N/A N/A C: Financial Instruments with similar economic effect to Qualifying Financial Instruments xv, xvi Resulting situation after the triggering transaction Type of financial Exercise Expiration Exercise/ Number of voting % of voting instrument price date xvii Conversion rights instrument rights xix, xx period xviii refers to Nominal Delta N/A N/A N/A N/A N/A N/A N/A Total (A+B+C) Number of voting rights Percentage of voting rights 5,100,000 8.00% 9. Chain of controlled undertakings through which the voting rights and/or the financial instruments are effectively held, if applicable: xxi N/A Proxy Voting: 10. Name of the proxy holder: N/A 11. Number of voting rights proxy holder will cease to hold: N/A 12. Date on which proxy holder will cease to hold voting rights: N/A 13. Additional information: Calculation based on 63,778,516 shares in issue 14. Contact name: Joanna Nottingham 15. Contact telephone number: 01482 394149
UK 100

Latest directors dealings