Material purchase by CIO of the Investment Manager

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NOTIFICATION OF MAJOR HOLDINGS (to be sent to the relevant issuer and to the FCA in Microsoft Word format if possible) ⁱ

1a. Identity of the issuer or the underlying issuer of existing shares to which voting rights are attached ⁱⁱ:			RTW BIOTECH OPPORTUNITIES LTD
1b. Please indicate if the issuer is a non-UK issuer (please mark with an "X" if appropriate)
Non-UK issuer						X
2. Reason for the notification (please mark the appropriate box or boxes with an "X")
An acquisition or disposal of voting rights						X
An acquisition or disposal of financial instruments
An event changing the breakdown of voting rights
Other (please specify) ⁱⁱⁱ:
3. Details of person subject to the notification obligation ^iv
Name			RODERICK WONG
City and country of registered office (if applicable)			NEW YORK, UNITED STATES
4. Full name of shareholder(s) (if different from 3.) ^v
Name			PGGL FAMILY TRUST LLC, WONG GIFT TRUST 2019, AND RTW FUND GROUP GP LLC
City and country of registered office (if applicable)			NEW YORK, UNITED STATES
5. Date on which the threshold was crossed or reached ^vi:			24 FEB 2025
6. Date on which issuer notified (DD/MM/YYYY):			25 FEB 2025
7. Total positions of person(s) subject to the notification obligation
	% of voting rights attached to shares (total of 8. A)	% of voting rights through financial instruments (total of 8.B 1 + 8.B 2)		Total of both in % (8.A + 8.B)	Total number of voting rights held in issuer (8.A + 8.B) ^vii
Resulting situation on the date on which threshold was crossed or reached	15.0000%	0.0000%		15.0000%	50,356,880
Position of previous notification (if applicable)	10.9939%	0.0000%		10.9939%

8. Notified details of the resulting situation on the date on which the threshold was crossed or reached ^viii
A: Voting rights attached to shares
Class/type of shares ISIN code (if possible)		Number of voting rights ^ix					% of voting rights
		Direct (DTR5.1)		Indirect (DTR5.2.1)			Direct (DTR5.1)		Indirect (DTR5.2.1)
GG00BKTRRM22		50,356,880		0			15.0000%		0.0000%


SUBTOTAL 8. A		50,356,880					15.0000%

B 1: Financial Instruments according to DTR5.3.1R (1) (a)
Type of financial instrument		Expiration date ^x	Exercise/ Conversion Period ^xi			Number of voting rights that may be acquired if the instrument is exercised/converted.			% of voting rights



			SUBTOTAL 8. B 1

B 2: Financial Instruments with similar economic effect according to DTR5.3.1R (1) (b)
Type of financial instrument	Expiration date ^x		Exercise/ Conversion Period ^xi		Physical or cash Settlement ^xii			Number of voting rights	% of voting rights



					SUBTOTAL 8.B.2

9. Information in relation to the person subject to the notification obligation (please mark the applicable box with an "X")
Person subject to the notification obligation is not controlled by any natural person or legal entity and does not control any other undertaking(s) holding directly or indirectly an interest in the (underlying) issuer ^xiii
Full chain of controlled undertakings through which the voting rights and/or the financial instruments are effectively held starting with the ultimate controlling natural person or legal entity (please add additional rows as necessary) ^xiv				X
Name ^xv	% of voting rights if it equals or is higher than the notifiable threshold	% of voting rights through financial instruments if it equals or is higher than the notifiable threshold	Total of both if it equals or is higher than the notifiable threshold
RODERICK WONG (controlling person)
PGGL Family Trust LLC (controlled undertaking 1)	14.8781%	0.0000%	14.8781%
RODERICK WONG (controlling person)
Wong Gift Trust 2019 (controlled undertaking 2)	0.0878%	0.0000%	0.0878%
RODERICK WONG (controlling person)
RTW Fund Group GP LLC (controlled undertaking 3)	0.0341%	0.0000%	0.0341%

10. In case of proxy voting, please identify:
Name of the proxy holder
The number and % of voting rights held
The date until which the voting rights will be held

11. Additional information ^xvi

Place of completion	United Kingdom
Date of completion	24 February 2025

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