Holding(s) in Company

Proteome Sciences PLC
12 December 2003



Proteome Sciences plc ('the Company')


NOTIFICATION OF MAJOR INTERESTS IN SHARES


Disclosure Under Section 198 of the Companies Act


The Company received a notification today from Credit Lyonnais Securities
informing it that they have an interest in 6,036,500 ordinary shares
representing 5.07% of the issued ordinary share capital of the Company.



12 December 2003




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