Holding(s) in Company

Proteome Sciences PLC
13 November 2003

Proteome Sciences plc ('the Company')

NOTIFICATION OF MAJOR INTERESTS IN SHARES

Disclosure Under Section 198 of the Companies Act

The Company received a notification today from Credit Lyonnais Securities
informing it that they have an interest in 4,956,500 ordinary shares
representing 4.16% of the issued ordinary share capital of the Company.

13 November 2003




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