Hospital to adopt Steriwave as standard-of-care
9 October 2023
ONDINE BIOMEDICAL INC.
("Ondine Biomedical", "Ondine" or the "Company")
Hospital to adopt Steriwave as standard-of-care
Penticton Regional Hospital (PRH), located in the Okanagan area of British Columbia, has committed to implementing Canadian life sciences company Ondine Biomedical's (LON: OBI) Steriwave® nasal photodisinfection technology as standard-of-care for patients undergoing orthopedic surgery. Penticton Regional Hospital, affiliated with UBC Faculty of Medicine, currently undertakes approximately 900 orthopedic surgeries annually.
The PRH team has selected Steriwave as a highly effective method of preventing hospital-acquired infections (HAIs) following surgery. This is particularly important due to growing concern about antimicrobial resistance (AMR), as hospitals must adapt their protocols to combat the rapid rise of drug-resistant pathogens.
One in nine hospital patients in Canada gets a healthcare-associated infection (HAI) resulting in around 12,000 deaths a year.1 HAIs are also becoming harder to treat due to rising rates of antimicrobial resistance (AMR) which are making some commonly used antibiotics ineffective.2 This has meant that one in 19 deaths in Canada are now attributable to antibiotic-resistant infections.3 The cost of AMR to the Canadian healthcare sector is also projected to increase from $1.4 billion to $7.6 billion per year by 2050.4
Ondine Biomedical's CEO, Carolyn Cross, said:
"We are very pleased that Steriwave will soon be adopted as the standard-of-care for patients undergoing orthopedic surgeries performed at Penticton Regional Hospital. It is gratifying to be working with Interior Health and this orthopedics team who are so committed to combatting the risk of post-surgical infections and keeping their patients safe against rising rates of antibiotic resistance. This also demonstrates Steriwave's growing status as an effective alternative to topical antibiotics for infection prevention that easily fits into existing hospital workflows."
Ondine's nasal photodisinfection treatment kills all types of pathogens - viruses, bacteria, and fungi - without causing resistance and is already in use in major hospitals across Canada, including Vancouver General and UBC Hospitals in BC, The Ottawa Hospital (Ontario), the Mazankowski Alberta Heart Institute (Alberta), and the Montreal Heart Institute (Quebec).
Nasal photodisinfection is a non-antibiotic method for nasal decolonization that uses a proprietary light-activated agent to destroy pathogens. First, the agent is applied to each nostril using a nasal swab, then the area is illuminated with a specific wavelength of light. The light activates the photodynamic agent, causing an oxidative burst that destroys pathogens. In this single, 5-minute treatment, Steriwave eliminates infection-causing bacteria, viruses, and fungi in the nose.5
**ENDS**
About Ondine Biomedical Inc.
Ondine Biomedical Inc. is a Canadian headquartered company innovating in the field of photodisinfection therapies. Ondine has a pipeline of investigational products, based on its proprietary photodisinfection platform, in various stages of development. Products beyond nasal photodisinfection include therapies for a variety of medical indications such as chronic sinusitis, ventilator-associated pneumonia, burns, and other indications.
About Nasal Photodisinfection
Ondine's nasal photodisinfection is a patented technology using a proprietary photosensitizer (non- antibiotic, light-activated agent) to destroy pathogens. The photodisinfection treatment is carried out by a trained healthcare professional, and is an easy-to-use, painless, two-step process. The photosensitizer is applied to each nostril using a nasal swab, followed by illumination of the area with a specific wavelength of laser light for less than five minutes. The light activates the photosensitizer, causing an oxidative burst that is lethal to all types of pathogens. A key benefit of this approach, unlike with antibiotics, is that pathogens do not develop resistance to the therapy.
Nasal decolonization with antibiotics is already standard practice in many hospitals prior to surgery, as pathogens in a patient's nasal cavities are a major cause of surgical site infections (SSIs). However, there is a growing need to reduce antibiotic use and find non-antibiotic methods of nasal decolonization as resistance rates have been reported as high as 81%.2
Ondine's nasal photodisinfection system has a CE mark in Europe and the UK and is approved in Canada and several other countries under the name Steriwave™. It has been used in Canada for over ten years, with no serious adverse events reported. In the US, it is currently undergoing clinical trials for regulatory approval.
About Penticton General Hospital
The Penticton Regional Hospital (PRH) is in the Okanagan health service area and responsible for providing core medical and surgical specialty services to patients throughout its service area. Located in Penticton, between Kelowna and Oliver, PRH offers services including 24-hour emergency and trauma services, acute services, ambulatory and outpatient clinics, and diagnostic/paramedical services.
[1] https://cupe.ca/health-care-associated-infections-backgrounder-and-fact-sheet
2 Poovelikunnel T, Gethin G, Humphreys H. Mupirocin resistance: clinical implications and potential alternatives for the eradication of MRSA. J Antimicrob Chemother. 2015 Oct;70(10):2681-92. doi: 10.1093/jac/dkv169. Epub 2015 Jul 3.
3 Healthcare-associated infections and antimicrobial resistance in Canadian acute care hospitals, CCDR 49(5) - C anada.ca
4 Healthcare-associated infections and antimicrobial resistance in Canadian acute care hospitals, CCDR 49(5) - Canada.ca
5 Liu Z, Norman G, Iheozor-Ejiofor Z, Wong JK, Crosbie EJ, Wilson P. Nasal decontamination for the prevention of surgical site infection in Staphylococcus aureus carriers. Cochrane Database Syst Rev. 2017 May 18;5(5):CD012462. doi: 10.1002/14651858.CD012462.pub2. PMID: 28516472; PMCID: PMC6481881.
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