Latozinemab data read out

Summary by AI BETAClose X

GSK and Alector announced the results from the INFRONT-3 clinical trial of latozinemab for frontotemporal dementia due to a progranulin gene mutation (FTD-GRN). While the treatment showed a statistically significant effect on the biomarker co-primary endpoint of plasma progranulin (PGRN) concentrations, it did not demonstrate a benefit in slowing FTD-GRN progression, the clinical co-primary endpoint. Furthermore, secondary and exploratory endpoints did not show treatment-related effects. Consequently, the open-label extension of the INFRONT-3 trial and the continuation study for latozinemab will be discontinued. GSK will analyze the complete data to guide future research. In July 2021, GSK and Alector entered into a collaboration where costs for global development were divided between the two companies.

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