Directorate Change

GlaxoSmithKline PLC
17 January 2006


                     GlaxoSmithKline plc Directorate Change

GlaxoSmithKline plc (GSK) today announced that, following the disclosure of a
potential conflict of interest, Dr Ralph Horwitz has decided not to take up his
appointment as a Non-Executive Director of the Company.

S M Bicknell
Company Secretary

17 January 2006


Enquiries:

UK Media enquiries:                     Philip Thomson          [phone]
                                        David Mawdsley          [phone]

US Media enquiries:                     Nancy Pekarek           [phone]

European Analyst/Investor enquiries:    Duncan Learmouth        [phone]
                                        Anita Kidgell           [phone]
                                        Jen Hill                [phone]

US Analyst/ Investor enquiries:         Frank Murdolo           [phone]
                                        Tom Curry               [phone]



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