Poster Presentations at AACR 2023
Faron Pharmaceuticals Oy
("Faron" or the "Company")
Faron Pharmaceuticals Announces Poster Presentations on Bexmarilimab at the American Association for Cancer Research Annual Meeting 2023
Press Release, April 18, 2023
TURKU, FINLAND / BOSTON, MA : Faron Pharmaceuticals Oy (AIM: FARN, First North: FARON), a clinical-stage biopharmaceutical company focused on tackling cancers via novel immunotherap ies , announces the presentation of two posters at the American Association for Cancer Research Annual Meeting 2023 in Orlando, Florida.
Details of the poster presentations are as follows:
|
Title: |
CLEVER-1/PD-L1 ratio predicts response to bexmarilimab, a novel macrophage-guided immunotherapy, in immune-deprived cancers |
|
Abstract ID: |
Section 37, Board 9 |
|
Date/Time: |
Tuesday, April 18, 9:00 a.m. EST |
|
Title: |
Bexmarilimab induces B-cell activation and autoantibody production |
|
Abstract ID: |
Section 43, Board 16 |
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Date/Time: |
Monday, April 17, 9:00 a.m. EST |
The first poster indicates a PD-L1/CLEVER-1 IHC staining ratio may be used to predict bexmarilimab response, as responding patients have a low PD-L1 and high CLEVER-1 staining, as well as low inflammatory cytokine (IFN γ, TNF α, IL-6) levels as reported previously. This finding means they are often refractory to checkpoint inhibitors and other T cell activating agents.
"The finding supports patient selection for planned combination studies with PD-1 blockade refractory patients," said CEO Dr. Markku Jalkanen. Indications in the upcoming BEXCOMBO study include metastatic head and neck squamous cell carcinoma, urothelial carcinoma and non-small cell lung cancer where first-line PD-1 blockade is the approved standard of care.
The second poster indicates that bexmarilimab can induce activation and secondary Ig rearrangements in mature B-cells. B-cell diversity and activation is considered important for cancer immune recognition.
The abstracts will be available in the AACR journal Cancer Research.
For more information please contact:
Media Contact
Faron Pharmaceuticals
Jennifer C. Smith-Parker
Head of Communications
Jennifer.Smith-Parker@faron.com
Investor Contact
Faron Pharmaceuticals
Julia Balanova
VP, Investor Relations
Phone: +1 (917) 306-6096
Cairn Financial Advisers LLP, Nomad
Sandy Jamieson, Jo Turner
Phone: +44 (0) 207 213 0880
Peel Hunt LLP, Broker
Christopher Golden, James Steel
Phone: +44 (0) 20 7418 8900
Sisu Partners Oy, Certified Adviser on Nasdaq First North
Juha Karttunen
Phone: +358 (0)40 555 4727
Jukka Järvelä
Phone: +358 (0)50 553 8990
Consilium Strategic Communications
David Daley, Lindsey Neville, Namrata Taak
Phone: +44 (0)20 3709 5700
About Bexmarilimab
Bexmarilimab is Faron's wholly owned, investigational immunotherapy with the potential to provide immune stimulation for treatment-resistant cancers through targeting myeloid cell function. A novel anti-CLEVER-1 humanized antibody, bexmarilimab targets CLEVER-1 positive (Common Lymphatic Endothelial and Vascular Endothelial Receptor 1) tumor-associated macrophages (TAMs) in the tumor microenvironment, converting highly immunosuppressive M2 macrophages to immune-stimulating M1 macrophages. As an immuno-oncology therapy, bexmarilimab has therapeutic potential in combination with other standard treatments including immune checkpoint molecules in both solid tumors and hematologic malignancies.
About Faron Pharmaceuticals Oy
Faron Pharmaceuticals Oy (AIM: FARN, First North: FARON), together with its subsidiaries, is a clinical stage biopharmaceutical group focused on building the future of immunotherapy by harnessing the power of the immune system to tackle cancer. Bexmarilimab , a novel anti-CLEVER-1 humanized antibody, is its investigational immunotherapy with the potential to remove immunosuppression of cancers through targeting myeloid cell function. Bexmarilimab is being investigated in Phase I/II clinical trials as a potential therapy for patients with hematological and solid cancers in combination with other standard treatments including immune checkpoint molecules. Faron is headquartered in Turku, Finland. Further information is available at www.faron.com .
Forward-Looking Statements
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