Issue of Equity

18 December 2025

THIS ANNOUNCEMENT CONTAINS INSIDE INFORMATION

Pensana Plc ("Pensana" or the "Company")

Issue of Equity

Pensana Plc (LSE: PRE) (the "Company") announces that, further to the Major shareholder support for US strategy announcement released earlier today, application has been made for the 23,148,148 New Ordinary Shares to be admitted to the Official List and to trading on the Main Market of the LSE and Admission is expected to occur on the LSE on or about 08:00 on 22 December 2025. These shares rank pari passu with the existing Ordinary Shares in issue.

Following this issue, the Company's issued share capital consists of 338,114,583 Ordinary Shares. No shares are held in treasury. Therefore, the total number of voting rights of the Company is 338,114,583

The above figure may be used by shareholders as the denominator for the calculations by which they will determine if they are required to notify their interest in, or a change in their interest in, the Company under the Financial Conduct Authority's Disclosure and Transparency Rules.

The information contained within this announcement is considered by the Company to constitute inside information as stipulated under the Market Abuse Regulations (EU) No.596/2014. Upon the publication of this announcement via a Regulatory Information Service, this inside information will be considered to be in the public domain. The person responsible for arranging for the release of this announcement on behalf of the Company is Paul Atherley (Chairman).

-ENDS-

For further information, please contact: Shareholder/analyst enquiries:

Pensana Plc

Paul Atherley, Chairman   [e-mail] Tim George, Chief Executive Officer

Rob Kaplan, Chief Financial Officer

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